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公开(公告)号：US12103173B2
公开(公告)日：2024-10-01
申请号：US16091193
申请日：2017-04-20
IPC分类号： B25J9/04 , A61L27/36 , B25J9/02 , B25J9/16 , B29C64/141 , B29C64/209 , B29C64/379 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00
CPC分类号： B25J9/045 , A61L27/36 , B25J9/023 , B25J9/16 , B29C64/141 , B29C64/209 , B29C64/379 , B33Y70/00 , B33Y10/00 , B33Y30/00 , B33Y80/00
摘要： Described are systems and methods for in vivo multi-material bioprinting. The in vivo multi-material bioprinting can be used to fabricate biomedical constructs within a patient minimally invasively. The systems and methods can utilize a multi-material bioprinter, which includes a biocompatible portion. The biocompatible portion can include a single printhead for in vivo bioprinting. The single printhead can include a plurality of outlets, each linked to one of a plurality of reservoirs. Each of the plurality of reservoirs can each house a different bioink for bioprinting. Each of the plurality of outlets can be activated to release a respective bioink.
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公开(公告)号：US20240156083A1
公开(公告)日：2024-05-16
申请号：US18506291
申请日：2023-11-10
发明人： Yu Shrike Zhang , Zeyu Luo
IPC分类号： A01N1/02 , C12N5/077 , C12N5/0775 , C12N5/079
CPC分类号： A01N1/0284 , A01N1/0221 , C12N5/0618 , C12N5/0656 , C12N5/0658 , C12N5/0662 , C12N2513/00 , C12N2533/54 , C12N2537/10
摘要： A method of making a 3D-printed biomaterial is described. The method includes depositing a hydrogel comprising cells and a cryoprotectant from a 3D printer onto a freezing plate to form a frozen hydrogel filament; depositing additional hydrogel comprising cells and a cryoprotectant from a 3D printer in contact with a previously placed frozen hydrogel filament to form a 3D-printed biomaterial comprising a plurality of frozen hydrogel filaments; and removing the 3D-printed biomaterial from the freezing plate. 3D-printed biomaterials made by the method are also described.
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公开(公告)号：US12007687B2
公开(公告)日：2024-06-11
申请号：US18324452
申请日：2023-05-26
IPC分类号： B29C64/00 , B22F10/00 , B22F10/85 , B22F12/00 , B22F12/82 , B29C64/10 , B29C64/106 , B29C64/176 , B29C64/182 , B29C64/20 , B29C64/205 , B29C64/227 , B29C64/245 , B29C64/25 , B29C64/255 , B29C64/30 , B29C64/307 , B29C64/386 , B29C64/393 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y40/10 , B33Y40/20 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , B33Y99/00 , G03F7/00
CPC分类号： G03F7/001 , B22F10/00 , B22F10/85 , B22F12/00 , B22F12/82 , B29C64/00 , B29C64/10 , B29C64/106 , B29C64/176 , B29C64/182 , B29C64/20 , B29C64/205 , B29C64/227 , B29C64/245 , B29C64/25 , B29C64/255 , B29C64/30 , B29C64/307 , B29C64/386 , B29C64/393 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y40/10 , B33Y40/20 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , B33Y99/00 , G03F7/00
摘要： Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.
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公开(公告)号：US20230359117A1
公开(公告)日：2023-11-09
申请号：US18324452
申请日：2023-05-26
IPC分类号： G03F7/00 , B33Y80/00 , B29C64/106 , B33Y70/00 , B29C64/00 , B29C64/205 , B29C64/386 , B33Y40/20 , B29C64/176 , B33Y10/00 , B33Y40/10 , B29C64/245 , B29C64/25 , B33Y50/00 , B29C64/40 , B22F12/00 , B29C64/393 , B29C64/227 , B33Y40/00 , B22F10/00 , B29C64/255 , B33Y50/02 , B22F10/85 , B29C64/20 , B29C64/10 , B33Y30/00 , B29C64/30 , B29C64/307 , B33Y99/00 , B29C64/182 , B22F12/82
CPC分类号： G03F7/001 , B33Y80/00 , B29C64/106 , B33Y70/00 , B29C64/00 , G03F7/00 , B29C64/205 , B29C64/386 , B33Y40/20 , B29C64/176 , B33Y10/00 , B33Y40/10 , B29C64/245 , B29C64/25 , B33Y50/00 , B29C64/40 , B22F12/00 , B29C64/393 , B29C64/227 , B33Y40/00 , B22F10/00 , B29C64/255 , B33Y50/02 , B22F10/85 , B29C64/20 , B29C64/10 , B33Y30/00 , B29C64/30 , B29C64/307 , B33Y99/00 , B29C64/182 , B22F12/82
摘要： Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.
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公开(公告)号：US20240228925A1
公开(公告)日：2024-07-11
申请号：US18558234
申请日：2022-05-02
发明人： Yu Shrike Zhang
CPC分类号： C12M21/08 , C12M23/26 , C12M35/04 , C12N9/1044 , C12Y203/02013
摘要： An alveolar lung model apparatus, including: an elastic hydrogel disposed within a housing, the hydrogel including a plurality of sacs; and a pressure chamber disposed within the housing and adjacent to the hydrogel, the pressure chamber coupled to the hydrogel such that changes in pressure within the pressure chamber cause deformation of the hydrogel.
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公开(公告)号：US11693311B2
公开(公告)日：2023-07-04
申请号：US16660956
申请日：2019-10-23
IPC分类号： B29C64/00 , G03F7/00 , B33Y80/00 , B29C64/106 , B33Y70/00 , B29C64/205 , B29C64/386 , B33Y40/20 , B29C64/176 , B33Y10/00 , B33Y40/10 , B29C64/245 , B29C64/25 , B33Y50/00 , B29C64/40 , B22F12/00 , B29C64/393 , B29C64/227 , B33Y40/00 , B22F10/00 , B29C64/255 , B33Y50/02 , B22F10/85 , B29C64/20 , B29C64/10 , B33Y30/00 , B29C64/30 , B29C64/307 , B33Y99/00 , B29C64/182 , B22F12/82
CPC分类号： G03F7/001 , B22F10/00 , B22F10/85 , B22F12/00 , B22F12/82 , B29C64/00 , B29C64/10 , B29C64/106 , B29C64/176 , B29C64/182 , B29C64/20 , B29C64/205 , B29C64/227 , B29C64/245 , B29C64/25 , B29C64/255 , B29C64/30 , B29C64/307 , B29C64/386 , B29C64/393 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y40/10 , B33Y40/20 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , B33Y99/00 , G03F7/00
摘要： Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.
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公开(公告)号：US20200324469A1
公开(公告)日：2020-10-15
申请号：US16091193
申请日：2017-04-20
IPC分类号： B29C64/171 , B29C64/141 , B29C64/209 , B29C64/379 , B25J9/16 , B25J9/02 , B25J9/04 , A61L27/36
摘要： Described are systems and methods for in vivo multi-material bioprinting. The in vivo multi-material bioprinting can be used to fabricate biomedical constructs within a patient minimally invasively. The systems and methods can utilize a multi-material bioprinter, which includes a biocompatible portion. The biocompatible portion can include a single printhead for in vivo bioprinting. The single printhead can include a plurality of outlets, each linked to one of a plurality of reservoirs. Each of the plurality of reservoirs can each house a different bioink for bioprinting. Each of the plurality of outlets can be activated to release a respective bioink.
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公开(公告)号：US20240002786A1
公开(公告)日：2024-01-04
申请号：US18036924
申请日：2021-11-19
发明人： Yu Shrike Zhang , Tina Vermonden , Cari Schuurmans
CPC分类号： C12N5/0062 , B33Y70/00 , B33Y40/20 , B29C64/30 , C12N2513/00 , C12N2533/70 , C12N2537/10 , B29C64/124
摘要： A method of shrinking a hydrogel is described. The method includes contacting a polyionic hydrogel with a polyionic solution including an ionic polymer having a net opposite charge from that of the polyionic hydrogel for an amount of time sufficient to decrease the volume of the polyionic hydrogel. Hydrogel compositions made using this method, and methods of using these hydrogels in 3D printing are also described.
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