公开(公告)号：US08030612B2

公开(公告)日：2011-10-04

申请号：US12240060

申请日：2008-09-29

Applicant: Bruce A. Collings ,  Yves J. C. Leblanc

Inventor： Bruce A. Collings ,  Yves J. C. Leblanc

IPC: H01J49/42

CPC classification number: H01J49/427 ,  H01J49/0045

Abstract: Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor.

Abstract translation: 使用低压和低振幅离子激发的组合来改进离子离子离子的分离方法，包括从离子阱离子群体除去具有与感兴趣的离子的离子相近的离子的离子的质谱法 提供改进的离子检测分辨率的方法，以及用其指令编程的可编程装置。

公开(公告)号：US06909089B2

公开(公告)日：2005-06-21

申请号：US10449912

申请日：2003-05-30

Applicant: Frank R. Londry ,  William R. Stott ,  Bruce A. Collings ,  James Hager

Inventor： Frank R. Londry ,  William R. Stott ,  Bruce A. Collings ,  James Hager

IPC: G01N27/62 ,  H01J49/42

CPC classification number: H01J49/4225

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

Abstract translation: 本发明解决了在质谱仪中有时可能出现的伪像鬼峰的问题，该质谱仪采用四极棒组，用于捕获和质量分析捕获的离子。 该问题是由于沿着棒的长度随机分布的电压梯度而产生的。 提出了三种解决方案。 第一种方法包括提高棒组的传导特性。 第二种方法包括将至少一个连续的轴向DC场施加到陷阱四极杆组，以便将离子推向阱的预定区域，从而避免电压梯度。 第三种方法涉及应用一个或多个离散的轴向场以沿着阱的轴向尺寸产生一个或多个势垒（除用于最初捕获离子的阻挡层外）。 这些障碍防止不同电压梯度的离子彼此平衡。

公开(公告)号：US20120112054A1

公开(公告)日：2012-05-10

申请号：US13251554

申请日：2011-10-03

Applicant: Bruce A. Collings ,  Yves J.C. LeBlanc

Inventor： Bruce A. Collings ,  Yves J.C. LeBlanc

IPC: H01J49/26

CPC classification number: H01J49/427 ,  H01J49/0045

Abstract: Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor.

Abstract translation: 使用低压和低振幅离子激发的组合来改进离子离子离子的分离方法，包括从离子阱离子群体除去具有与感兴趣的离子的离子相近的离子的离子的质谱法 提供改进的离子检测分辨率的方法，以及用其指令编程的可编程装置。

公开(公告)号：US07259371B2

公开(公告)日：2007-08-21

申请号：US11315788

申请日：2005-12-22

Applicant: Bruce A. Collings ,  Thomas R. Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre V. Loboda ,  Bradley B. Schneider ,  Bruce A. Thomson

Inventor： Bruce A. Collings ,  Thomas R. Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre V. Loboda ,  Bradley B. Schneider ,  Bruce A. Thomson

IPC: H01J49/00

CPC classification number: H01J49/067 ,  H01J49/063

Abstract: In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

Abstract translation: 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20090121126A1

公开(公告)日：2009-05-14

申请号：US12240060

申请日：2008-09-29

Applicant: Bruce A. Collings ,  Yves J.C. Leblanc

Inventor： Bruce A. Collings ,  Yves J.C. Leblanc

IPC: B01D59/44

CPC classification number: H01J49/427 ,  H01J49/0045

Abstract: Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor.

Abstract translation: 使用低压和低振幅离子激发的组合来改进离子离子离子的分离方法，包括从离子阱离子群体除去具有与感兴趣的离子的离子相近的离子的离子的质谱法 提供改进的离子检测分辨率的方法，以及用其指令编程的可编程装置。

公开(公告)号：US07227137B2

公开(公告)日：2007-06-05

申请号：US10508950

申请日：2003-04-02

Applicant: Frank Londry ,  Bruce A. Collings ,  William R. Stott

Inventor： Frank Londry ,  Bruce A. Collings ,  William R. Stott

IPC: H01J49/42 ,  H01J49/00 ,  B01D59/44

CPC classification number: H01J49/4225 ,  H01J49/0063

Abstract: In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

Abstract translation: 在质谱领域中，以分辨率和效率较高的方式分离离子的方法和装置。 该技术包括将离子捕获在线性离子阱中，其中背景或中性气体压力优选在10 -5 Torr量级。 被俘获的离子在相对较低的激发水平（例如小于1伏特（0-pk））下相对延长的时间段（例如超过50ms）被共振激发。 该技术允许高选择性地离解离子。 可以通过将高阶多极场叠加到用于捕获离子的四极RF场上来实现高碎裂效率。 多极场，优选是八极场，抑制在陷阱周边的共振激发的离子的径向振荡运动。 这降低了离子从陷阱径向射出的可能性，从而增加了碰撞诱导解离的可能性。

公开(公告)号：US06191417B1

公开(公告)日：2001-02-20

申请号：US09188352

申请日：1998-11-10

Applicant: Donald J. Douglas ,  Zhaohui Du ,  Bruce A. Collings

Inventor： Donald J. Douglas ,  Zhaohui Du ,  Bruce A. Collings

IPC: H01J4942

CPC classification number: H01J49/421 ,  H01J49/004 ,  H01J49/288 ,  H01J49/429

Abstract: A method is provided of operating a mass spectrometer apparatus comprising a pair of quadrupole rod sets. Each quadrupole rod set is operated in a mass resolving mode. They may be operated in the same or different stability regions. The rod sets are operated to select essentially ions of the same mass to charge ratio, and are operated such that the combined resolution of the two rod sets is greater than the resolution of either rod set. The rod sets can be operated at relatively low resolution, with the combined peak shape from the two rod sets showing high resolution. This can make up for mechanical imperfections in the rod sets, losses due to high gas pressures, etc. A mass shift can be provided to give the desired resolution. The rod sets can be close coupled, and for this purpose neutralizing capacitors can be provided to prevent electrical interference between adjacent rod sets. The rod sets can be provided with the same frequency signal, which preferably is a phase locked and shifted, to give enhanced sensitivity.

Abstract translation: 提供了一种操作包括一对四极杆组的质谱仪装置的方法。 每个四极杆组以质量分辨模式运行。 它们可以在相同或不同的稳定性区域中操作。 操作杆组以选择基本上具有相同质荷比的离子，并且操作使得两个杆组的组合分辨率大于任一杆组的分辨率。 杆组可以相对较低的分辨率操作，两个组合的组合峰形显示高分辨率。 这可以弥补棒组中的机械缺陷，由于气体压力高导致的损失等。可以提供质量偏移以给出所需的分辨率。 杆组可以紧密连接，为此，可以提供中和电容器以防止相邻杆组之间的电气干扰。 杆组可以设置有相同的频率信号，其优选地是锁相和偏移的，以提供增强的灵敏度。

公开(公告)号：US08378298B2

公开(公告)日：2013-02-19

申请号：US13251554

申请日：2011-10-03

Applicant: Bruce A. Collings ,  Yves J. C. Leblanc

Inventor： Bruce A. Collings ,  Yves J. C. Leblanc

IPC: H01J49/42

CPC classification number: H01J49/427 ,  H01J49/0045

Abstract: Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor.

Abstract translation: 使用低压和低振幅离子激发的组合来改进离子离子离子的分离方法，包括从离子阱离子群体除去具有与感兴趣的离子的离子相近的离子的离子的质谱法 提供改进的离子检测分辨率的方法，以及用其指令编程的可编程装置。

公开(公告)号：US07923681B2

公开(公告)日：2011-04-12

申请号：US12232618

申请日：2008-09-19

Applicant: Bruce A. Collings ,  Mircea Guna

Inventor： Bruce A. Collings ,  Mircea Guna

IPC: B01D59/44

CPC classification number: H01J49/0045 ,  H01J49/063

Abstract: A novel curved collision cell for a mass spectrometer is described. The collision cell includes a straight section having a length that is selected to cause a precursor ion entering the straight section to lose a desired amount of kinetic energy such that when the precursor ion enters the curved section of the collision cell the precursor ion will tend to neither escape nor contact the collision cell, and thereby tending to survive its passage within the curved portion.

Abstract translation: 描述了用于质谱仪的新型弯曲碰撞池。 碰撞单元包括具有选择的长度的直线段，以使前体离子进入直线段以失去所需量的动能，使得当前体离子进入碰撞池的弯曲部分时，前体离子将倾向于 既不逃逸也不接触碰撞室，从而趋于在弯曲部分内通过。

公开(公告)号：US07847248B2

公开(公告)日：2010-12-07

申请号：US12272998

申请日：2008-11-18

Applicant: Bruce A. Collings

Inventor： Bruce A. Collings

IPC: H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/4265

Abstract: Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers.

Abstract translation: 用于有效解决由离子阱过度填充引起的电荷空间影响的离子阱设备和方法，可用于质谱仪的线性离子阱。