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公开(公告)号：US10144917B2
公开(公告)日：2018-12-04
申请号：US15507620
申请日：2015-08-28
Applicant: CALIXAR , Université Claude Bernard Lyon 1 , Hospices Civils de Lyon , INSERM
Abstract: The present invention relates to a method for preparing a vaccine antigen, which includes a step of fragmenting a biological membrane associated with said vaccine antigen by treating said biological membrane with at least one calixarene of formula (II): wherein: X is a —(CH2)-CO2Y group and Y is an alkaline metal or one of the pharmaceutically acceptable salts thereof, wherein said resulting vaccine antigen also includes a fragment of the biological membrane associated with said antigen. The present invention also relates to a vaccine that can be produced by implementing the method, including a calixarene of formula (II) in carrier format, with a quantity of 0.1 to 1,000 μg in the total weight of the vaccine. The present invention further relates to the use of a calixarene as defined above for the preparation of a vaccine or a vaccine antigen, and to the vaccine for use as a drug in the treatment or prevention of an infectious disease.
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Patent Agency Ranking
公开(公告)号：US20170362578A1
公开(公告)日：2017-12-21
申请号：US15507620
申请日：2015-08-28
Applicant: CALIXAR , Université Claude Bernard Lyon 1 , Hospices Civils de Lyon , INSERM
IPC: C12N7/04 , A61K39/145 , C07C39/17 , A61K39/00
CPC classification number: C12N7/04 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07C39/17 , C12N7/00 , C12N2760/16134 , C12N2760/16151
Abstract: The present invention relates to a method for preparing a vaccine antigen, which includes a step of fragmenting a biological membrane associated with said vaccine antigen by treating said biological membrane with at least one calixarene of formula (II): wherein: X is a —(CH2)-CO2Y group and Y is an alkaline metal or one of the pharmaceutically acceptable salts thereof, wherein said resulting vaccine antigen also includes a fragment of the biological membrane associated with said antigen. The present invention also relates to a vaccine that can be produced by implementing the method, including a calixarene of formula (II) in carrier format, with a quantity of 0.1 to 1,000 μg in the total weight of the vaccine. The present invention further relates to the use of a calixarene as defined above for the preparation of a vaccine or a vaccine antigen, and to the vaccine for use as a drug in the treatment or prevention of an infectious disease.
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3.发明申请公开(公告)号：US20170022241A1
公开(公告)日：2017-01-26
申请号：US15303039
申请日：2015-04-08
Applicant: CALIXAR
Inventor： Julien DAUVERGNE
IPC: C07H15/26 , C07K14/00 , C07K14/705 , C07K1/14 , C07H15/24
CPC classification number: C07H15/26 , B01D11/0288 , C07H13/04 , C07H13/12 , C07H15/04 , C07H15/24 , C07K1/145 , C07K14/00 , C07K14/70571
Abstract: Amphiphilic calixarene glycoside compounds, the preparation of such compounds, and the use of such compounds for selectively extracting, solubilizing and stabilizing membrane proteins.
Abstract translation: 两亲性杯芳烃糖苷化合物，这些化合物的制备，以及这些化合物用于选择性提取，增溶和稳定膜蛋白的用途。
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公开(公告)号：US10525117B2
公开(公告)日：2020-01-07
申请号：US15050155
申请日：2016-02-22
Applicant: MERIAL, INC. , CALIXAR , GENOSTAR , VETAGRO-SUP , INSTITUT PASTEUR
Inventor： Natalia Ines Bomchil , Jean-Baptiste Claude , Lionel Pierre Christian Cupillard , Célia Fontana , Anass Jawhari , Elodie Mandon , Angeli Kodjo , Mathieu Picardeau , Azad Eshghi
Abstract: The present invention provides compositions and methods for eliciting heterologous protective immunity in animals against Leptospira spp. The Leptospira spp. immunoprotective peptides disclosed herein elicit protective immunity against subsequent challenge or exposure to at least two Leptospira spp. serovars.
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公开(公告)号：US09695209B2
公开(公告)日：2017-07-04
申请号：US15303039
申请日：2015-04-08
Applicant: CALIXAR
Inventor： Julien Dauvergne
IPC: A61K31/7004 , C07D249/06 , C07D249/08 , C07H15/04 , C07H15/26 , C07H13/04 , C07H13/12 , C07H15/24 , C07K1/14 , C07K14/00 , C07K14/705 , B01D11/02
CPC classification number: C07H15/26 , B01D11/0288 , C07H13/04 , C07H13/12 , C07H15/04 , C07H15/24 , C07K1/145 , C07K14/00 , C07K14/70571
Abstract: Amphiphilic calixarene glycoside compounds, the preparation of such compounds, and the use of such compounds for selectively extracting, solubilizing and stabilizing membrane proteins.
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6.发明申请Leptospira Immunoprotective Proteins and Methods of Identification and Use Thereof 审中-公开钩端螺旋体免疫保护蛋白及其鉴定和使用方法公开(公告)号：US20170021004A1
公开(公告)日：2017-01-26
申请号：US15050155
申请日：2016-02-22
Applicant: MERIAL, INC. , CALIXAR , GENOSTAR , VETAGRO-SUP , INSTITUT PASTEUR
Inventor： Natalia Ines Bomchil , Jean-Baptiste Claude , Lionel Pierre Christian Cupillard , Célia Fontana , Anass Jawhari , Elodie Mandon , Angeli Kodjo , Mathieu Picardeau , Azad Eshghi
CPC classification number: A61K39/0208 , A61K9/0019 , A61K39/0225 , A61K2039/54 , A61K2039/545 , A61P31/04 , C07K14/20 , C12N15/74 , Y02A50/48
Abstract: The present invention provides compositions and methods for eliciting heterologous protective immunity in animals against Leptospira spp. The Leptospira spp. immunoprotective peptides disclosed herein elicit protective immunity against subsequent challenge or exposure to at least two Leptospira spp. serovars.
Abstract translation: 本发明提供了用于在动物体内产生针对钩端螺旋体属（Leptospira spp）的异源保护性免疫的组合物和方法。 钩端螺旋体属 本文公开的免疫保护肽引起针对随后的攻击或暴露于至少两种钩端螺旋体属的保护性免疫。 血清型
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