摘要:
WHERE R2 is hydrogen, chloro- or dimethylamino-.
WHERE X is -O- or -S-, R and R1 are hydrogen, methyl or hydroxymethyl and are the same or different, and Z is methyl, ethyl, methoxymethyl, p-methoxyphenyl; or 4,4-dimethyl-2oxazolylethyl; 4,4-dimethyl-2-oxazolylbutyl; or the group
A method of tranquilizing warm-blooded animals comprising administering thereto orally or intravenously a tranquilizing amount of a compound, or a phramaceutically acceptable salt thereof, corresponding to the formula
摘要:
Tranquilizing agents for warm-blooded animals corresponding to the formula
Where n can be 1 or 2; Y can be --(CH.sub.2).sub.n -- or
Where R.sup.2 can be hydrogen or an alkyl, alkenyl, alkoxy, phenyl or methoxyphenyl radical. Z can be thenyl, furyl, phenyl; or mono-, di-, or trimethoxyphenyl, mono-, or dichlorophenyl, or dichlorophenoxy. R and R.sup.1 can be hydrogen, methyl, or ethyl and can be the same or different.
摘要:
THIS INVENTION PROVIDES A NEW SYNTHESIS FOR NORZEARALANE II AND RELATED COMPOUNDS WHICH RELATED COMPOUNDS AND NORZEARALANE II ARE REPRESENTED BY THE FORMULA
1,5-DI(HO-),2,3-(-CO-O-CH2-(CH2)X-)-BENZENE
WHERE X IS AN INTEGER HAVING A VALUE FROM 1 TO 13 INCLUSIVE. THE ANABOLIC AGENT NORZEARALANE II, IN WHICH X=9 IN THEFOREGOING FORMULA, IS PREPARED BY A TOTAL CHEMICAL SYNTHESIS INVOLVING THE REACTION OF 10-UNDECENAL WITH MALONIC ACID TO PRODUCE TRANS-2,12-TRIDECADIENOIC ACID; TREATING THE ACID SO FORMED WITH DIAZOMSTHANE TO YIELD METHYL TRANS-2,12-TRIDECADIENOATE; REACTING THE METHYL ESTER WITH ETHYL ACETOACETATE AND SODIUM ETHOXIDE TO FORM THE SODIUM SALT OF ETHYL 6-(9-DECENYL)-B-DIHYDRORESORCYLATE; BROMINATING THE DIHYDRORESORCYLATE TO PREPARE ETHYL 3-BROMO- 6 - (9-DECENYL)-B-DIHYDRORESOCRYLATE; DE-HYDROBROMINATING THE FOREGOING BROMO DERIVATIVE TO GIVE ETHYL 6-(9-DECENYL)-B-RESORCYLATE; REACTING THE RESORCYLATE ESTER WITH BENZYL CHLORIDE TO PRODUCE ETHYL 6-(9-DECENYL)-BRESORCYLATE DIBENZYL ETHER; SUBJECTING THE BENZYLATED ESTER TO THE ACTION OF DIBORANE, WATER AND HYDROGEN PEROXIDE TO FORM ETHYL 2,4-BIS (BENZYLOXY)-6-(10-HYDROXYDECYL)BENZOATE; TREATING THE FOREGOING BENZOATE WITH SODIUM ETHOXIDE TO PREPARE NORZEARALANE II DIBENZYL ETHER, ONE ALSO TO PREPARE AS A BY-PRODUCT THE DIMERIC DILACTONE OF 2,4-BIS(BENZYLOXY)-6-(10-HYDROXYDECYL)-BENZOIC ACID; HYDROGENATING NORZEARALANE II DIBENZYL ETHER TO FORM NORZEARALANE II. IN GENERAL, A HOMOLOGUE OF NORZEARALANE II AND/OR OF THE CORRESPONDING DIMERIC DILACTONE IS PREPARED BY SUBSTITUTING FOOR 10-UNDECENAL IN THE FOREGOING SEQUENCE OF REACTIONS AN UNSATURATED ALDEHYDE HAVING THE FORMULA
CH2=CH-(CH2)X-1-CHO
WHERE X IS AN INTEGER WHICH MAY HAVE THE VALUE 1,2,3,4, 5, 6, 7, 8, 9, 10, 11, 12 OR 13 SPECIFICALLY ZEARALANE II (WHERE X=10) IS PREPARED STARTING WITH 11-DODECENAL AND THE DIMERIC DILACTONE FROM 6-(5-HYDROXYPENTYL-B-RESORCYCLIC ACID DIBENZYL ETHER IS PREPARED WHEN THE STARTING ALDEHYDE IS 5-HEXENAL (WHERE X= 4) THE INVENTION ALSO COVERS PHYSIOLOGICALLY ACTIVE COMPOUNDS RELATED TO THE ZEARALANES II AND KNOW AS DIMERIC DILACTONES HAVING THE FORMULA,
X IS AN INTEGER WHICH MAY HAVE THE VALUE 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 OR 13 AND WHERE R IS EITHE HYDROGEN OR A BENZYL RADICAL (C6H5CH2-). MORE PARTICULARLY, THIS INVENTION RELATES TO NOVEL INTERMEDIATES PRODUCED IN THE SYNTHESIS OF THE ABOVE COMPOUNDS AND TO PROCESSES FOR MAKING THESE INTERMEDIATES.
摘要:
A method of administering cycloserine to an animal for prophylactic or therapeutic purposes by metering a concentrated alkaline solution of cycloserine into the drinking water provided for the animal in an amount sufficient to provide an effective dosage.
摘要:
A PRIMER ADAPTED TO INITIATING DETONATION OF NITROMETHANE BY STRONG SHOCK COMPRISING AN OPEN-CELLED POLYMERIC FOAM CONTAINING ABOUT 15-85% BY WEIGHT OF GLASS BUBBLES.
摘要:
A PROCESS FOR COATING STEEL BY APPLYING THERETO A MONOMER OR PARTIAL POLYMER OF A VINYL OXAZOLINE, REPRESENTED BY THE FORMULA
2-(CH2=C(-R)-),4-R1,4-R2-2-OXAZOLINE
WHEREIN R IS AN ALKYL OR ALKENYL GROUP OF 1 TO 20 CARBON STOMS AND R1 AND R2 ARE SELECTED FROM THE GROUP CONSISTIG OF METHYL, ETHYL, HYDROXYMETHYL, OR THE ACYLOXYMETHYL GROUP REPRESENTED BY THE FORMULA
-CH2-OOC-CH2-R
OR THE VINYL ACYLOXYMETHYL GROUP REPRESENTED BY THE FORMULA
-CH2-OOC-C(-R)=CH2
HEATING TO EFFECT FURTHER POLYMERIZATION, APPLYING THERETO A SOLUTION OR DISPERSION OF A VINYL HALIDE POLYMER, COPOLYMER, OR TERPOLYMER AND HEATING TO EFFECT EVAPORATION OF THE SOLVENT OR COALESCENE OF THE DISPERSION.
摘要:
New compounds are provided and have the formula
WHERE B is
R and R'' can be hydrogen, alkyl, acyl or aralkyl radicals; and X and Y are hydrogen or chlorine and at least one of X and Y is chlorine. These compounds exhibit antibacterial activity and can be used in animal feed compositions.
摘要:
RESIN COMPOSITIONS SUITABLE FOR BAKED COATINGS CONSISTING OF THE CONDENSATION PRODUCT OF A LOWER ALIPHATIC ALDEHYDE AND UREA EFFECTED IN THE PRESENCE OF DIMETHYLOLPROPIONIC ACID (DMPA). A METHOD IS PROVIDED FOR COATING PAPER WITH THE COMPOSITION.
摘要:
A WATER-SOLUBLE ALKYL RESIN COMPOSITION AND A 2-STEP PROCESS FOR THE PREPARATION THEREOF COMPRISING THE PRODUCT OF THE REACTION OF AN ALIPHATIC MONOCARBOXYLIC ACID WITH DI- OR TRIPENTAERYTHRITOL, WHICH PRODUCT IS THEN REACTED WITH PHTHALIC ANHYDRIDE TO AN ACID NUMBER OF 70-100, THEN NEUTRALIZED. THE COMPOSITION IS USEFUL IN THE FORMULATION OF PROTECTIVE COATINGS, ESPECIALLY THOSE INTENDED FOR APPLICATION BY THE ELECTRO-DEPOSITION PROCESS.