公开(公告)号：US5225529A

公开(公告)日：1993-07-06

申请号：US471525

申请日：1990-01-29

申请人： Edoardo Butelman ,  Cesare Sirtori

发明人： Edoardo Butelman ,  Cesare Sirtori

IPC分类号： C07H15/02 ,  A61K31/70 ,  A61K31/7028 ,  A61P25/28 ,  C07C201/00 ,  C07H7/033 ,  C07H15/04 ,  C07H15/06 ,  C07H15/26 ,  C07H19/16 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00 ,  C07K14/685 ,  C07K14/69 ,  C07K14/695

CPC分类号： C07H15/04 ,  C07H15/06 ,  C07H15/26 ,  C07H19/16 ,  C07H7/033 ,  C07K14/685 ,  C07K14/69 ,  C07K14/6955

摘要： Chemically and sterically pure synthetic amphiphilic glycoconjugates for neurological use of the formula (I): ##STR1## in which: the saccharide ring represents a monosaccharide such as glucose, galactose or mannose;X represents O or NH and, when X represents O, R is a choline radical whereas, when X represents NH, R is an amino acid or peptide radical; R' represents a saturated or unsaturated linear or branched C.sub.8 -C.sub.18 aliphatic chain, or a ##STR2## group where m is between 7 and 17 and; n is a whole number from 1 to 5.

公开(公告)号：US4439366A

公开(公告)日：1984-03-27

申请号：US392891

申请日：1982-06-28

申请人： Carlo Scolastico ,  Cesare Sirtori ,  David Kritchevsky

发明人： Carlo Scolastico ,  Cesare Sirtori ,  David Kritchevsky

IPC分类号： A61K31/575 ,  A61P1/16 ,  C07J9/00 ,  C07J13/00

CPC分类号： C07J9/005

摘要： Novel compounds are described, which are 7-acyl-chenodeoxycholic acid of formula (I) ##STR1## in which R-CO is the residue from a linear, saturated or unsaturated carboxylic acid of 3-18 carbon atoms or the residue from a cycloalkanecarboxylic acid of 3-7 carbon atoms in the cycloalkane ring. The compounds are prepared by selective hydrolysis of the 3,7-diacyl derivatives of chenodeoxycholic acid. The compounds are valuable against biliary calculosis, diskinesia and hypertriglyceridemia.

摘要翻译： 描述了新的化合物，其是式（I）的7-酰基 - 鹅脱氧胆酸（I），其中R-CO是3-18个碳原子的直链，饱和或不饱和羧酸的残基或残基 来自环烷烃环中3-7个碳原子的环烷基羧酸。 通过选择性水解鹅脱氧胆酸的3,7-二酰基衍生物来制备化合物。 这些化合物对于胆汁计算性，药物滥用和高甘油三酯血症是有价值的。

公开(公告)号：US20170367678A1

公开(公告)日：2017-12-28

申请号：US15189864

申请日：2016-06-22

申请人： Cesare SIRTORI ,  Dionysis GOULARAS ,  Fabien LABOMBARDA

发明人： Cesare SIRTORI ,  Dionysis GOULARAS ,  Fabien LABOMBARDA

IPC分类号： A61B8/08 ,  A61B8/00

CPC分类号： A61B8/0891 ,  A61B8/085 ,  A61B8/4483 ,  A61B8/461 ,  A61B8/488 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/5246

摘要： Provided is an ultrasound automated method for measuring the thickness of the walls of arteries. The method includes utilizing an apparatus that includes an ultrasonic device, a tracking system, a QI system, a 3D generator, a cross-section generator, a display driver, and a display. The ultrasound automated method includes, e.g.,: defining a fixed frame of reference, detecting the position of the ultrasonic device in respect to the fixed frame of reference, recording a set of 2D images, to be transmitted by the ultrasonic device to the database of the QI system structure, placing the reference sensor over the arterial walls, selecting the proximal and distal walls of the arteries, selecting the length of the walls to be measured in order to proceed to thickness determination, investigating over the length of the selected coronary segment, the mean arterial thickness (AT) and lumen area (LA).

公开(公告)号：US06617134B1

公开(公告)日：2003-09-09

申请号：US09259434

申请日：1999-03-01

申请人： Cesare Sirtori ,  Guido Franceschini ,  Lars Abrahmsén ,  Erik Holmgren ,  Mats Lake ,  Björn Nilsson ,  Joanna Chmielewska ,  Peter Lind

发明人： Cesare Sirtori ,  Guido Franceschini ,  Lars Abrahmsén ,  Erik Holmgren ,  Mats Lake ,  Björn Nilsson ,  Joanna Chmielewska ,  Peter Lind

IPC分类号： C12P2104

CPC分类号： C07K14/775 ,  A61K38/1709 ,  Y02A50/473

摘要： Substantially pure dimers of Apolipoprotein AI-Milano (APO-AI-M/APO AI-M) were isolated from plasma and characterized. Apolipoprotein AI-M dimer can also be produced in a recombinant Escherichia coli system. Pharmaceutical compositions comprising the ApoAI-AI-M/ApoAI-M are described. Patients with atherosclerosis or cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used to prevent thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

摘要翻译： 从血浆中分离出载脂蛋白AI-Milano（APO-AI-M / APO AI-M）的基本纯二聚体并进行表征。 载脂蛋白AI-M二聚体也可以在重组大肠杆菌系统中产生。 描述了包含ApoAI-AI-M / ApoAI-M的药物组合物。 可以用二聚体治疗动脉粥样硬化或心血管疾病患者。 含有二聚体的药物也可用于在动脉和静脉水平的不同临床情况下预防血栓形成。 二聚体也可以作为单体的前药。

公开(公告)号：US5876968A

公开(公告)日：1999-03-02

申请号：US104063

申请日：1993-11-04

申请人： Cesare Sirtori ,  Guido Franceschini ,  Lars Abrahmsen ,  Erik Holmgren ,  Mats Lake ,  Bjorn Nilsson ,  Joanna Chmielewska ,  Peter Lind

发明人： Cesare Sirtori ,  Guido Franceschini ,  Lars Abrahmsen ,  Erik Holmgren ,  Mats Lake ,  Bjorn Nilsson ,  Joanna Chmielewska ,  Peter Lind

IPC分类号： C12P21/00 ,  A61K35/16 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/33 ,  A61P3/06 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K1/00 ,  C07K1/18 ,  C07K1/20 ,  C07K14/775 ,  C07K19/00 ,  C12N15/16 ,  C12P21/04 ,  C12P21/06 ,  C07K14/00

CPC分类号： C07K14/775 ,  A61K38/1709

摘要： Substantially pure dimers of Apolipoprotein Al-Milano (Al-M/APO Al-M) isolated and characterized from plasma are provided. Pharmaceutical compositions comprising the Apo Al-M/Apo Al-M are also provided. Apolipoprotein Al-M dimer can be produced in a recombinant Escherichia coli system or collected from plasma from Apolipoprotein Al-Milano carriers. Atherosclerosis and cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used for preventing thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

摘要翻译： PCT No.PCT / SE92 / 00858 Sec。 371日期：1993年11月4日 102（e）日期1993年11月4日PCT 1992年12月11日PCT PCT。 第WO93 / 12143号公报 日期1993年6月24日提供了从等离子体分离和表征的载脂蛋白Al-Milano（Al-M / APO Al-M）的基本纯二聚体。 还提供了包含Apo Al-M / Apo Al-M的药物组合物。 载脂蛋白A1-M二聚体可以在重组大肠杆菌系统中产生或从载脂蛋白Al-Milano载体的血浆中收集。 动脉粥样硬化和心血管疾病可用二聚体治疗。 含有二聚体的药物也可用于在动脉和静脉水平的不同临床情况下预防血栓形成。 二聚体也可以作为单体的前药。

公开(公告)号：US4559345A

公开(公告)日：1985-12-17

申请号：US400434

申请日：1982-07-21

申请人： Piero Gomarasca ,  Carlo Scolastico ,  Cesare Sirtori

发明人： Piero Gomarasca ,  Carlo Scolastico ,  Cesare Sirtori

IPC分类号： A61K31/505 ,  A61K31/53 ,  A61P3/06 ,  A61P9/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D251/42 ,  C07D251/44 ,  C07D251/46 ,  C07D251/50 ,  C07D251/18

CPC分类号： C07D239/47 ,  C07D239/48 ,  C07D251/42 ,  C07D251/44 ,  C07D251/46

摘要： Pyrimidine and s-triazine derivatives of formula (I) ##STR1## in which X=CH or N; Y=for example halogen, alkoxy; W=for example --S--CH.sub.2 --COOH, --O--CH.sub.2 --COO alkyl, --NH--CH.sub.2 --CONHCH.sub.2 CH.sub.2 OH; Z=for example 2,3-xylidino, and methods for the preparation thereof are described. The compounds show high antilipemic activity.

摘要翻译： 式（I）的嘧啶和s-三嗪衍生物其中X = CH或N; Y =例如卤素，烷氧基; W =例如-S-CH 2 -COOH，-O-CH 2 -COO烷基，-NH-CH 2 -CONHCH 2 CH 2 OH; Z =例如2,3-亚甲二酰基，并描述其制备方法。 该化合物显示出高的抗血脂活性。

公开(公告)号：US4440688A

公开(公告)日：1984-04-03

申请号：US392634

申请日：1982-06-28

申请人： Carlo Scolastico ,  Cesare Sirtori ,  David Kritchevsky

发明人： Carlo Scolastico ,  Cesare Sirtori ,  David Kritchevsky

IPC分类号： A61K31/575 ,  A61P1/16 ,  C07J9/00 ,  C07J13/00

CPC分类号： C07J9/005

摘要： Novel compounds which are 7-acylderivatives of ursodeoxycholic acid are described of formula ##STR1## in which R-CO is the residue from a linear, saturated or unsaturated, carboxylic acid of 2-18 carbon atoms or the residue from a cycloalkanecarboxylic acid of 3-7 carbon atoms in the cycloalkane ring. The novel compounds are useful in the therapy of biliary calculosis, biliary diskinesia and hypertriglyceridemia.

摘要翻译： 醛脱氧胆酸的7-酰基衍生物的新型化合物描述于其中R-CO为2-18个碳原子的直链，饱和或不饱和的羧酸或来自环烷烃羧酸的残基的式（I） 环烷烃环中3-7个碳原子的酸。 该新型化合物可用于治疗胆汁性脑血管病，胆汁性蝶呤和高甘油三酯血症。