公开(公告)号：US08299072B2

公开(公告)日：2012-10-30

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D231/12 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/10

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US20100004286A1

公开(公告)日：2010-01-07

申请号：US12256701

申请日：2008-10-23

申请人： Yong Seo CHO ,  Ae Nim PAE ,  Hyunah CHOO ,  Jae Kyun LEE ,  You Na OH ,  Hee Sup SHIN ,  Dong Jin KIM ,  Hoh Gyu HAHN ,  Kyung Il CHOI ,  Ghilsoo NAM ,  Kye Jung SHIN ,  Soon Bang KANG ,  Eun Joo ROH ,  Dong Yun SHIN ,  Seon Hee SEO ,  Hyewhon RHIM ,  Gyo Chang KEUM ,  Key-Sun KIM ,  Chan Seong CHEONG ,  Eunice Eun-Kyeong KIM ,  Cheolju LEE ,  Youngsoo KIM ,  Kee Hyun CHOI ,  Kee Dal NAM ,  Woong Seo PARK ,  Yong Koo KANG ,  Hye Jin CHUNG

发明人： Yong Seo CHO ,  Ae Nim PAE ,  Hyunah CHOO ,  Jae Kyun LEE ,  You Na OH ,  Hee Sup SHIN ,  Dong Jin KIM ,  Hoh Gyu HAHN ,  Kyung Il CHOI ,  Ghilsoo NAM ,  Kye Jung SHIN ,  Soon Bang KANG ,  Eun Joo ROH ,  Dong Yun SHIN ,  Seon Hee SEO ,  Hyewhon RHIM ,  Gyo Chang KEUM ,  Key-Sun KIM ,  Chan Seong CHEONG ,  Eunice Eun-Kyeong KIM ,  Cheolju LEE ,  Youngsoo KIM ,  Kee Hyun CHOI ,  Kee Dal NAM ,  Woong Seo PARK ,  Yong Koo KANG ,  Hye Jin CHUNG

IPC分类号： A61K31/454 ,  C07D401/12 ,  A61P35/00 ,  A61P9/12 ,  A61P25/08

CPC分类号： C07D401/12 ,  A61K31/454

摘要： Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. wherein R1˜R6 are as defined in the specification.

摘要翻译： 公开了由化学式1表示的具有对T型钙通道的抑制活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法和包含其作为活性成分的药物组合物。 其中R1〜R6如说明书中所定义。

公开(公告)号：US20100094006A1

公开(公告)日：2010-04-15

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： C07D403/12 ,  C07D241/04 ,  C07D231/12

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US20110319456A1

公开(公告)日：2011-12-29

申请号：US13142313

申请日：2009-12-29

申请人： Hoh-Gyu Hahn ,  Kee-Dal Nam ,  Dong-Yun Shin ,  Chan-Ho Park ,  Sung-Woo Cho ,  Eun-A Kim ,  Ghil-Soo Nam ,  Kyung-Il Chol ,  Seon-Hee Seo ,  Hee-Sup Shin ,  Dong-JIn Kim ,  Ae-Nim Pae ,  Hye-JIn Chung ,  Hyun-Ah Choo ,  Hye-Whon Rhim ,  Yong-Seo Cho ,  Eun-Jon Roh ,  Gyo-Chang Keum ,  Kee-Hyun Choi ,  Kye-Jung Shin ,  Chan-Seong Cheong ,  Jae-Kyun Lee ,  Yong-Koo Kang ,  Young-Soo Kim ,  Woong-Seo Park ,  Key-Sun Kim ,  He-Sson Chung ,  Chi-Man Song ,  Sun-Joon Min ,  Eunlce Eun-Kyeong Kim ,  Cheol-Ju Lee ,  Soon-Bang Kang

发明人： Hoh-Gyu Hahn ,  Kee-Dal Nam ,  Dong-Yun Shin ,  Chan-Ho Park ,  Sung-Woo Cho ,  Eun-A Kim ,  Ghil-Soo Nam ,  Kyung-Il Chol ,  Seon-Hee Seo ,  Hee-Sup Shin ,  Dong-JIn Kim ,  Ae-Nim Pae ,  Hye-JIn Chung ,  Hyun-Ah Choo ,  Hye-Whon Rhim ,  Yong-Seo Cho ,  Eun-Jon Roh ,  Gyo-Chang Keum ,  Kee-Hyun Choi ,  Kye-Jung Shin ,  Chan-Seong Cheong ,  Jae-Kyun Lee ,  Yong-Koo Kang ,  Young-Soo Kim ,  Woong-Seo Park ,  Key-Sun Kim ,  He-Sson Chung ,  Chi-Man Song ,  Sun-Joon Min ,  Eunlce Eun-Kyeong Kim ,  Cheol-Ju Lee ,  Soon-Bang Kang

IPC分类号： A61K31/428 ,  C07D235/30 ,  C07D417/12 ,  A61P25/16 ,  A61K31/4184 ,  A61K31/423 ,  A61P25/28 ,  A61P25/00 ,  C07D277/82 ,  C07D263/58

CPC分类号： C07D277/82 ,  C07D235/22 ,  C07D263/58 ,  C07D327/04 ,  C07D333/06

摘要： Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.

摘要翻译： 提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。 神经变性脑疾病可包括阿尔茨海默病，痴呆，帕金森病，中风，淀粉样变性，皮克病，卢格里希氏病，亨廷顿舞蹈病，克雅氏病，雅各布病等。

公开(公告)号：US20090325979A1

公开(公告)日：2009-12-31

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/497 ,  C07D403/06 ,  C07D233/54

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US09012481B2

公开(公告)日：2015-04-21

申请号：US13142313

申请日：2009-12-29

申请人： Hoh-Gyu Hahn ,  Kee-Dal Nam ,  Dong-Yun Shin ,  Chan-Ho Park ,  Sung-Woo Cho ,  Eun-A Kim ,  Ghil-Soo Nam ,  Kyung-Il Chol ,  Seon-Hee Seo ,  Hee-Sup Shin ,  Dong-Jin Kim ,  Ae-Nim Pae ,  Hye-Jin Chung ,  Hyun-Ah Choo ,  Hye-Whon Rhim ,  Yong-Seo Cho ,  Eun-Joo Roh ,  Gyo-Chang Keum ,  Kee-Hyun Choi ,  Kye-Jung Shin ,  Chan-Seong Cheong ,  Jae-Kyun Lee ,  Yong-Koo Kang ,  Young-Soo Kim ,  Woong-Seo Park ,  Key-Sun Kim ,  He-Sson Chung ,  Chi-Man Song ,  Sun-Joon Min ,  Eunice Eun-Kyeong Kim ,  Cheol-Ju Lee ,  Soon-Bang Kang

发明人： Hoh-Gyu Hahn ,  Kee-Dal Nam ,  Dong-Yun Shin ,  Chan-Ho Park ,  Sung-Woo Cho ,  Eun-A Kim ,  Ghil-Soo Nam ,  Kyung-Il Chol ,  Seon-Hee Seo ,  Hee-Sup Shin ,  Dong-Jin Kim ,  Ae-Nim Pae ,  Hye-Jin Chung ,  Hyun-Ah Choo ,  Hye-Whon Rhim ,  Yong-Seo Cho ,  Eun-Joo Roh ,  Gyo-Chang Keum ,  Kee-Hyun Choi ,  Kye-Jung Shin ,  Chan-Seong Cheong ,  Jae-Kyun Lee ,  Yong-Koo Kang ,  Young-Soo Kim ,  Woong-Seo Park ,  Key-Sun Kim ,  He-Sson Chung ,  Chi-Man Song ,  Sun-Joon Min ,  Eunice Eun-Kyeong Kim ,  Cheol-Ju Lee ,  Soon-Bang Kang

IPC分类号： C07D235/22 ,  C07D263/58 ,  C07D333/06 ,  C07D327/04 ,  C07D277/82

CPC分类号： C07D277/82 ,  C07D235/22 ,  C07D263/58 ,  C07D327/04 ,  C07D333/06

摘要： Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.

摘要翻译： 提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。 神经变性脑疾病可包括阿尔茨海默病，痴呆，帕金森病，中风，淀粉样变性，皮克病，卢格里希氏病，亨廷顿舞蹈病，克雅氏病，雅各布病等。

公开(公告)号：US08492384B2

公开(公告)日：2013-07-23

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/496 ,  C07D233/64

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。