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    Pyrazole derivatives
    1.
    发明申请
    Pyrazole derivatives 失效
    吡唑衍生物

    公开(公告)号：US20050004129A1

    公开(公告)日：2005-01-06

    申请号：US10669794

    申请日：2003-09-23

    申请人： Lyn Jones ,  Charles Mowbray ,  David Price ,  Matthew Selby ,  Paul Stupple

    发明人： Lyn Jones ,  Charles Mowbray ,  David Price ,  Matthew Selby ,  Paul Stupple

    IPC分类号： A61K31/4709 ,  A61K31/498 ,  A61P31/18 ,  C07D401/06 ,  C07D403/06 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07

    CPC分类号： C07D417/04 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D487/04

    摘要： This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4, n W, X and Y are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

    摘要翻译： 本发明涉及式（I）的吡唑衍生物或其药学上可接受的盐，溶剂化物或衍生物，其中R 1至R 4，n W，X和Y在说明书中定义，以及制备方法 其制备中使用的含有它们的组合物和这些衍生物的用途。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。 因此，本发明的化合物可用于治疗各种病症，包括其中涉及逆转录酶的抑制的病症。 感兴趣的疾病包括由人免疫缺陷病毒（HIV）引起的遗传相关逆转录病毒，如获得性免疫缺陷综合征（AIDS）。

    Decoupler
    3.
    发明授权
    Decoupler 有权
    脱耦器

    公开(公告)号：US07585241B2

    公开(公告)日：2009-09-08

    申请号：US11572488

    申请日：2004-07-23

    申请人： Richard Terence Tamba ,  Mariusz Dudzik ,  Stephen Tapper ,  Paul Anthony Donnelly ,  Dennis Albert Rumble ,  Graham Charles Mowbray

    发明人： Richard Terence Tamba ,  Mariusz Dudzik ,  Stephen Tapper ,  Paul Anthony Donnelly ,  Dennis Albert Rumble ,  Graham Charles Mowbray

    IPC分类号： F16H47/08

    CPC分类号： F16H3/54 ,  B63H20/20 ,  B63H23/02 ,  B63H23/30 ,  B63H2023/0283 ,  F16H2045/0268

    摘要： A decoupler 10 having a rotatable input member 12 for coupling to a drive unit 13 and a rotatable output member 28 for coupling to an output drive, and a gear set 34 for transmitting drive from the rotatable input member 12 to the rotatable output member 28, wherein the decoupler 10 is operable to selectively isolate an input gear 36 of the gear set 34 from driving connection with the drive unit 13, and to selectively engage the input gear 36 into driving connection with the drive unit 13. The invention also relates to a method of transmitting torque and to a method of installing the decoupler 10.

    摘要翻译： 具有用于联接到驱动单元13的可旋转输入构件12和用于联接到输出驱动器的可旋转输出构件28的分离器10和用于将驱动从可旋转输入构件12传递到可旋转输出构件28的齿轮组34， 其中分离器10可操作以选择性地将齿轮组34的输入齿轮36与驱动单元13的驱动连接隔离，并且选择性地将输入齿轮36接合成与驱动单元13的驱动连接。本发明还涉及 传递扭矩的方法和安装解耦器10的方法。

    DRIVE SYSTEM WITH FLUID PUMP
    4.
    发明申请
    DRIVE SYSTEM WITH FLUID PUMP 审中-公开
    带流体泵的驱动系统

    公开(公告)号：US20090095548A1

    公开(公告)日：2009-04-16

    申请号：US11817222

    申请日：2006-02-28

    申请人： Richard Terrence Tamba ,  Stephen Tapper ,  Graham Charles Mowbray

    发明人： Richard Terrence Tamba ,  Stephen Tapper ,  Graham Charles Mowbray

    IPC分类号： B60K6/20 ,  F16H3/72 ,  F04B17/05 ,  F04B17/03

    CPC分类号： F16H57/0439 ,  B60K6/365 ,  B60K6/383 ,  B60K6/40 ,  B60K6/48 ,  B60K6/547 ,  B60K25/02 ,  B60W10/30 ,  B60W20/00 ,  F04B53/16 ,  F04C14/04 ,  F04C15/0061 ,  F04C15/066 ,  F04C2240/45 ,  F16H61/0021 ,  F16H61/0028 ,  F16H2061/0037 ,  Y02T10/6221

    摘要： A drive system (10) including an internal combustion engine (12), a planetary gear-set (16), an electric motor (18) and a transmission (20), wherein the internal combustion engine (12) and the electric motor (18) each drive the transmission (20) via the planetary gear set (16), and the electric motor (18) drives a fluid pump (22) of the transmission (20). In a further embodiment there is disclosed a fluid pump for pumping fluid from a source to a destination, wherein first and second inlet conduits are provided between the source and the pump, first and second outlet conduits are provided between the pump and the destination, and each of the conduits is provided with a valve allowing fluid flow through the conduit in only one direction, such that when the fluid pump is rotated in a first direction fluid is pumped through the first inlet and outlet conduits, and when the fluid pump is rotated in a second opposite direction fluid is pumped though the second inlet and outlet conduits.

    摘要翻译： 一种包括内燃机（12），行星齿轮组（16），电动机（18）和变速器（20）的驱动系统（10），其中内燃机（12）和电动马达 18）各自经由行星齿轮组（16）驱动变速器（20），电动机（18）驱动变速器（20）的流体泵（22）。 在另一实施例中，公开了一种用于将流体从源泵送到目的地的流体泵，其中在源和泵之间设置有第一和第二入口管道，第一和第二出口管道设置在泵和目的地之间，以及 每个导管设置有允许流体仅沿一个方向流过导管的阀，使得当流体泵在第一方向旋转时，流体被泵送通过第一入口和出口导管，并且当流体泵旋转时 在第二相反方向，流体被泵送通过第二入口和出口导管。

    Pyrazole derivatives
    6.
    发明申请
    Pyrazole derivatives 失效
    吡唑衍生物

    公开(公告)号：US20050054707A1

    公开(公告)日：2005-03-10

    申请号：US10657033

    申请日：2003-09-05

    申请人： Paul Edwards ,  Lyn Jones ,  Charles Mowbray ,  Paul Stupple ,  Isabelle Tran

    发明人： Paul Edwards ,  Lyn Jones ,  Charles Mowbray ,  Paul Stupple ,  Isabelle Tran

    IPC分类号： A61K31/4152 ,  A61K31/416 ,  A61K31/4439 ,  C07D43/02

    CPC分类号： C07D231/18

    摘要： This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

    摘要翻译： 本发明涉及式（I）的吡唑衍生物或其药学上可接受的盐，溶剂合物或衍生物，其中R 1至R 4在说明书中定义，及其制备方法，其制备中使用的中间体 的含有它们的组合物和这种衍生物的用途。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。 因此，本发明的化合物可用于治疗各种病症，包括其中涉及逆转录酶的抑制的病症。 感兴趣的疾病包括由人免疫缺陷病毒（HIV）引起的遗传相关逆转录病毒，如获得性免疫缺陷综合征（AIDS）。

    Pyrazole derivatives
    7.
    发明申请
    Pyrazole derivatives 有权
    吡唑衍生物

    公开(公告)号：US20060020012A1

    公开(公告)日：2006-01-26

    申请号：US11157340

    申请日：2005-06-20

    申请人： Lyn Jones ,  Charles Mowbray ,  David Price ,  Matthew Selby ,  Paul Stupple

    发明人： Lyn Jones ,  Charles Mowbray ,  David Price ,  Matthew Selby ,  Paul Stupple

    IPC分类号： C07D403/02 ,  C07D231/04 ,  A61K31/4152

    CPC分类号： C07D231/12 ,  C07D231/18 ,  C07D231/20 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04

    摘要： This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

    摘要翻译： 本发明涉及式（I）的吡唑衍生物或其药学上可接受的盐，溶剂化物或衍生物，其中R1至R4在说明书中定义，其制备方法，用于制备含有它们的组合物的中间体和 这种衍生物的用途。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。 因此，本发明的化合物可用于治疗各种病症，包括其中涉及逆转录酶的抑制的病症。 感兴趣的疾病包括由人免疫缺陷病毒（HIV）引起的遗传相关逆转录病毒，如获得性免疫缺陷综合征（AIDS）。