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1.发明申请SYSTEMS AND METHODS FOR PROVIDING PARENTAL CONTROLS IN A CLOUD-BASED MEDIA GUIDANCE APPLICATION 审中-公开基于云的媒体指导应用程序提供家长控制的系统和方法公开(公告)号：US20120324504A1
公开(公告)日：2012-12-20
申请号：US13341346
申请日：2011-12-30
申请人： Kuan Hidalgo Archer , Lloyd Dakin , Sam Hui , Neel Suhas Ketkar , Walter R. Klappert , Bo Hye Lee , Sean Charles Penn , Ben Ziskind , Bin Zhao
发明人： Kuan Hidalgo Archer , Lloyd Dakin , Sam Hui , Neel Suhas Ketkar , Walter R. Klappert , Bo Hye Lee , Sean Charles Penn , Ben Ziskind , Bin Zhao
IPC分类号： H04N21/266
CPC分类号： H04N21/4751 , H04N21/2743 , H04N21/278 , H04N21/4532 , H04N21/4627 , H04N21/4668 , H04N21/4753
摘要： Systems and methods for providing parental controls in a cloud-based media guidance application may provide users with compiled listings of the user's content and parental controls for accessing that and other content based on the user equipment devices from which the content access request is received. A user may identify remote storage providers at which user content is stored, and may provide criteria for limiting or preauthorizing access to selected content by one or more user equipment devices. In response to receiving a user request, a listing of content stored with the remote storage providers may be compiled and presented in a media guidance application. A selection of any one of the user's content, as well as a selection of any other content listed in the media guidance application, may be subject to access control criteria applicable to the user equipment device from which the selection was received.
摘要翻译： 在基于云的媒体指导应用中提供家长控制的系统和方法可以向用户提供用户内容和家长控制的编辑列表，以便基于从其接收内容访问请求的用户设备设备来访问和其他内容。 用户可以识别存储用户内容的远程存储提供商，并且可以提供用于限制或预授权对一个或多个用户设备设备对所选内容的访问的标准。 响应于接收到用户请求，存储在远程存储提供商中的内容的列表可以被编译并呈现在媒体引导应用中。 用户内容中的任何一个的选择以及媒体引导应用中列出的任何其他内容的选择可以受到适用于从其接收到选择的用户设备设备的访问控制标准。
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公开(公告)号：US20070184048A1
公开(公告)日：2007-08-09
申请号：US10571515
申请日：2004-09-13
申请人： Keith Foster , John Chaddock , Charles Penn
发明人： Keith Foster , John Chaddock , Charles Penn
IPC分类号： A61K39/00 , G01N33/567 , A61K39/395
CPC分类号： C12N9/52 , A61K47/64 , A61K47/642
摘要： The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties, to re-target a toxin to a cell of therapeutic interest. In particular, the present invention describes a method for designing a toxin conjugate, and describes therapeutic applications of said conjugates to inhibit or reduce cellular processes. Even more particularly, the present invention describes a method for designing toxin conjugates based upon non-cytotoxic toxins able to inhibit exocytosis, such as clostridial neurotoxins, and describes therapeutic applications of said conjugates to inhibit or reduce exocytosis (for example secretion, or the delivery of proteins such as receptors, transporters, and membrane channels to the plasma membrane of a cell).
摘要翻译： 本发明提供了一种用于设计用于治疗医学病症或疾病的再靶向毒素缀合物的方法。 还提供了所述缀合物在制备用于治疗医学病症或疾病的药物中的用途。 缀合物包括将缀合物引导至期望的靶细胞的靶向部位，其特征在于靶细胞增加靶细胞中的胞外融合。 本发明还提供了用于鉴定适合用作靶向部分的激动剂的方法，以及用于制备包含所述靶向部分的缀合物的方法，以将毒素重新靶向治疗感兴趣的细胞。 特别地，本发明描述了一种用于设计毒素缀合物的方法，并且描述了所述缀合物抑制或减少细胞过程的治疗应用。 甚至更具体地，本发明描述了一种基于能够抑制胞吐作用的非细胞毒素毒素（例如梭菌神经毒素）设计毒素缀合物的方法，并且描述了所述缀合物抑制或减少胞吐作用（例如分泌或递送）的治疗应用 的蛋白质，如受体，转运蛋白和膜通道的细胞质膜）。
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公开(公告)号：US08512984B2
公开(公告)日：2013-08-20
申请号：US13212868
申请日：2011-08-18
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Aoki , Joseph Francis , Lance Steward
CPC分类号： C12N9/96 , A61K38/482 , A61K38/4893 , A61K47/48246 , A61K47/64 , C07K14/665 , C07K2319/00
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a dynorphin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
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公开(公告)号：US20120156186A1
公开(公告)日：2012-06-21
申请号：US13343892
申请日：2012-01-05
申请人： Keith FOSTER , John CHADDOCK , Charles PENN , Kei Roger AOKI , Joseph FRANCIS , Lance STEWARD
发明人： Keith FOSTER , John CHADDOCK , Charles PENN , Kei Roger AOKI , Joseph FRANCIS , Lance STEWARD
CPC分类号： A61K38/4893 , A61K38/4886 , C07K14/575 , C07K2319/00 , C07K2319/01 , C12N9/52 , C12Y304/21072
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a galanin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are is also described.
摘要翻译： 本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。 所述蛋白质缀合物包括：（i）甘丙肽靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入物内的内体 细胞; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。 还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。
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公开(公告)号：US20120058098A1
公开(公告)日：2012-03-08
申请号：US13212868
申请日：2011-08-18
申请人： Keith FOSTER , John CHADDOCK , Charles PENN , Kei Roger AOKI , Joseph FRANCIS , Lance STEWARD
发明人： Keith FOSTER , John CHADDOCK , Charles PENN , Kei Roger AOKI , Joseph FRANCIS , Lance STEWARD
CPC分类号： C12N9/96 , A61K38/482 , A61K38/4893 , A61K47/48246 , A61K47/64 , C07K14/665 , C07K2319/00
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a dynorphin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
摘要翻译： 本发明涉及用于抑制或减少伤害性感觉传入细胞中胞外融合的非细胞毒性蛋白质缀合物。 所述蛋白质缀合物包含：（i）强啡肽靶向剂量（TM），其中所述TM是感受伤害感觉传入细胞上存在的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入物内的内体 细胞; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。 还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。
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公开(公告)号：US07658933B2
公开(公告)日：2010-02-09
申请号：US11829118
申请日：2007-07-27
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
CPC分类号： C07K14/575 , A61K31/711 , A61K38/4893 , A61K47/64 , A61K47/6415 , C07K14/33 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/6489 , C12N15/62 , C12Y304/24069
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
摘要翻译： 本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。 所述蛋白质缀合物包含：（i）靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入细胞内的内体 ; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。 还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。
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公开(公告)号：US20090291457A1
公开(公告)日：2009-11-26
申请号：US12534740
申请日：2009-08-03
申请人： Keith Foster , John Chaddock , Charles Penn
发明人： Keith Foster , John Chaddock , Charles Penn
IPC分类号： C12N9/52 , C12N9/50 , G01N33/567
CPC分类号： C12N9/52 , A61K47/64 , A61K47/642
摘要： The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties.
摘要翻译： 本发明提供了一种用于设计用于治疗医学病症或疾病的再靶向毒素缀合物的方法。 还提供了所述缀合物在制备用于治疗医学病症或疾病的药物中的用途。 缀合物包括将缀合物引导至期望的靶细胞的靶向部位，其特征在于靶细胞增加靶细胞中的胞外融合。 本发明还提供了用于鉴定适合用作靶向部分的激动剂的方法，以及制备包含所述靶向部分的缀合物的方法。
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公开(公告)号：US20090162341A1
公开(公告)日：2009-06-25
申请号：US11791979
申请日：2005-12-01
申请人： Keith Foster , John Chaddock , Charles Penn , Roger K. Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Roger K. Aoki , Joseph Francis , Lance Steward
CPC分类号： C07K14/575 , A61K31/711 , A61K38/4893 , A61K47/64 , A61K47/6415 , C07K14/33 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/6489 , C12N15/62 , C12Y304/24069
摘要： A non-cytotoxic protein conjugate for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) a Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of said nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
摘要翻译： 一种用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物，其包含：（i）靶向物质（TM），其中所述TM是存在于所述伤害性感觉传入细胞上的受体的激动剂，以及 其中所述受体经历内吞作用以掺入伤害性感觉传入细胞内的内体中; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割所述伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。 还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。
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公开(公告)号：US20080187960A1
公开(公告)日：2008-08-07
申请号：US11829118
申请日：2007-07-27
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
CPC分类号： C07K14/575 , A61K31/711 , A61K38/4893 , A61K47/64 , A61K47/6415 , C07K14/33 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/6489 , C12N15/62 , C12Y304/24069
摘要： A non-cytotoxic protein conjugate for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) a Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of said nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
摘要翻译： 一种用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物，其包含：（i）靶向物质（TM），其中所述TM是存在于所述伤害性感觉传入细胞上的受体的激动剂，以及 其中所述受体经历内吞作用以掺入伤害性感觉传入细胞内的内体中; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割所述伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。 还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。
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公开(公告)号：US20050112145A1
公开(公告)日：2005-05-26
申请号：US10494384
申请日：2002-11-01
申请人： Michael Hudson , Andrew Robinson , Nigel Silman , Bassam Hallis , Charles Penn
发明人： Michael Hudson , Andrew Robinson , Nigel Silman , Bassam Hallis , Charles Penn
CPC分类号： A61K39/07
摘要： An antigenic pharmaceutical composition is provided comprising Protective Antigen (PA) and Lethal Factor (LF), wherein said PA and/or LF lacks a functional binding site, thereby preventing said PA and LF from binding together via said binding site or thereby preventing said PA from binding to a native PA cell receptor via said binding site, and wherein said composition is substantially non-toxic to animal cells. The composition is for preventing or minimising anthrax toxicity in mammals, preferably in humans. Also provided are DNA and RNA based vaccines encoding the antigenic components of said pharmaceutical composition. The present specification also describes antibodies that bind to at least one of PA, LF or EF, which binding thereby prevents:—(i) PA from binding to LF or EF, or to a native PA cell receptor; or (ii) LF from binding to PA; or (iii) EF from binding to PA.
摘要翻译： 提供了包含保护性抗原（PA）和致死因子（LF）的抗原性药物组合物，其中所述PA和/或LF缺少功能性结合位点，从而防止所述PA和LF通过所述结合位点结合在一起，从而防止所述PA 通过所述结合位点与天然PA细胞受体结合，并且其中所述组合物对动物细胞基本上无毒性。 该组合物用于预防或最小化哺乳动物中的炭疽毒性，优选在人体内。 还提供了编码所述药物组合物的抗原成分的基于DNA和RNA的疫苗。 本说明书还描述了结合至少一种PA，LF或EF的抗体，其结合从而防止： - （i）PA结合LF或EF或天然PA细胞受体; 或（ii）LF结合PA; 或（iii）EF结合PA。
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