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公开(公告)号：US07977060B2
公开(公告)日：2011-07-12
申请号：US12147415
申请日：2008-06-26
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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2.发明授权Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1 有权包含T1R3和T1R1的哺乳动物甜味和氨基酸异二聚体味觉受体公开(公告)号：US07842786B2
公开(公告)日：2010-11-30
申请号：US12121576
申请日：2008-05-15
申请人： Charles S Zuker , Nicholas J. P. Ryba , Jayaram Chandrashekar , Mark A Hoon , Yifeng Zhang , Gregory A Nelson
发明人： Charles S Zuker , Nicholas J. P. Ryba , Jayaram Chandrashekar , Mark A Hoon , Yifeng Zhang , Gregory A Nelson
IPC分类号： C07K14/705 , G01N33/567 , C12N15/12
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含T1R3和T1R1的甜或氨基酸味受体的分离的核酸和氨基酸序列，来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，对这种受体的抗体， 检测这种核酸和受体，以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号：US20090104703A1
公开(公告)日：2009-04-23
申请号：US12326816
申请日：2008-12-02
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific polypeptides, antibodies to such polypeptides, methods of detecting such nucleic acids and polypeptides, and methods of screening for modulators of sensory cell specific polypeptides.
摘要翻译： 本发明提供了分离的感觉细胞特异性多肽的核酸和氨基酸序列，对这种多肽的抗体，检测此类核酸和多肽的方法，以及筛选感觉细胞特异性多肽调节剂的方法。
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公开(公告)号：US20090068733A1
公开(公告)日：2009-03-12
申请号：US11975655
申请日：2007-10-19
申请人： Charles S. Zuker , Jon Elliot Adler , Mark Hoon , Nick Ryba , Ken Mueller
发明人： Charles S. Zuker , Jon Elliot Adler , Mark Hoon , Nick Ryba , Ken Mueller
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
摘要翻译： 本发明提供了分离的嗜酸细胞特异性G蛋白偶联受体的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选味细胞特异性G蛋白偶联受体调节剂的方法。
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5.发明申请ASSAYS FOR SENSORY MODULATORS USING A SENSORY CELL SPECIFIC G-PROTEIN ALPHA SUBUNIT 审中-公开使用感应细胞特异性G蛋白ALPHA亚型的感测调节剂的测定公开(公告)号：US20080206785A1
公开(公告)日：2008-08-28
申请号：US12014215
申请日：2008-01-15
申请人： Charles S. Zuker
发明人： Charles S. Zuker
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/566 , G01N2333/705 , G01N2500/04
摘要： The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
摘要翻译： 本发明鉴定在感觉细胞中特异性表达的感觉细胞特异性G蛋白α亚基的核酸和氨基酸序列，例如味细胞，这种G蛋白α亚基的抗体，检测此类核酸和亚基的方法， 以及筛选感觉细胞特异性G蛋白α亚基的调节剂的方法。
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6.发明申请Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1 有权包含T1R3和T1R1的哺乳动物甜氨基酸异二聚味道感受器公开(公告)号：US20110151483A1
公开(公告)日：2011-06-23
申请号：US12944515
申请日：2010-11-11
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含T1R3和T1R1的甜或氨基酸味受体的分离的核酸和氨基酸序列，来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，对这种受体的抗体， 检测这种核酸和受体，以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号：US07745601B2
公开(公告)日：2010-06-29
申请号：US11975655
申请日：2007-10-19
申请人： Charles S. Zuker , Jon Elliot Adler , Mark Hoon , Nick Ryba , Ken Mueller
发明人： Charles S. Zuker , Jon Elliot Adler , Mark Hoon , Nick Ryba , Ken Mueller
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
摘要翻译： 本发明提供了分离的嗜酸细胞特异性G蛋白偶联受体的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选味细胞特异性G蛋白偶联受体调节剂的方法。
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公开(公告)号：US07507793B2
公开(公告)日：2009-03-24
申请号：US10645441
申请日：2003-08-20
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： C07H21/04 , G01N33/53 , G01N33/567 , C12P21/06 , C07K14/00
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US20090075294A1
公开(公告)日：2009-03-19
申请号：US11703343
申请日：2007-02-06
IPC分类号： G01N33/53
CPC分类号： C07K14/43581
摘要： The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
摘要翻译： 本发明首次提供了编码真核机械感应通道（MSC）蛋白质的核酸。 由这些核酸编码的蛋白质形成可以直接检测机械刺激并将其转换为电信号的通道。 这些核酸及其编码的蛋白质可用作动物感觉细胞的探针，可用于诊断和治疗许多涉及遗传，休闲或环境诱导的机械感觉转导活性丧失的人类病症。
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公开(公告)号：US20080318251A1
公开(公告)日：2008-12-25
申请号：US12121576
申请日：2008-05-15
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
IPC分类号： G01N33/566 , C07K14/47 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含来自感觉G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽的分离的核酸和氨基酸味道受体的氨基酸序列，这些受体的抗体，检测此类核酸的方法 和受体以及筛选甜味和氨基酸味觉受体调节剂的方法。
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