公开(公告)号：US5821336A

公开(公告)日：1998-10-13

申请号：US714927

申请日：1996-09-27

申请人： Karel Gerrit Odink ,  Lajos Tarcsay ,  Josef Bruggen ,  Walter Wiesendanger ,  Nico Cerletti ,  Clemens Sorg ,  Christiane DeWolf-Peeters ,  Jan Delabie

发明人： Karel Gerrit Odink ,  Lajos Tarcsay ,  Josef Bruggen ,  Walter Wiesendanger ,  Nico Cerletti ,  Clemens Sorg ,  Christiane DeWolf-Peeters ,  Jan Delabie

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  C12N15/63

CPC分类号： C07K14/52 ,  C07K16/24 ,  C07K16/3061 ,  A61K38/00

摘要： The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for the polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for the polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

摘要翻译： 本发明涉及具有大约160kD的表观分子量的多肽，其是炎症介质的介体或前体，其衍生物如突变体和片段，其制备方法，编码多肽和衍生物的DNA和杂交载体以及转化的宿主细胞 使用这些杂交载体，对多肽或其衍生物和抗体衍生物具有特异性的多克隆和单克隆抗体以及炎性病症和霍奇金淋巴瘤的诊断和治疗方法。

公开(公告)号：US20170138931A9

公开(公告)日：2017-05-18

申请号：US12422632

申请日：2009-04-13

申请人： JOHANNES ROTH ,  CLEMENS SORG

发明人： JOHANNES ROTH ,  CLEMENS SORG

IPC分类号： A61K31/4985 ,  A61P29/00

CPC分类号： G01N33/53 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/4727 ,  G01N2333/52 ,  G01N2800/065

摘要： The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

公开(公告)号：US5411882A

公开(公告)日：1995-05-02

申请号：US811893

申请日：1991-12-20

申请人： Karel G. Odink ,  Lajos Tarcsay ,  Josef Bruggen ,  Walter Wiesendanger ,  Nico Cerletti ,  Clemens Sorg ,  Christiane DeWolf-Peeters ,  Jan Delabie

发明人： Karel G. Odink ,  Lajos Tarcsay ,  Josef Bruggen ,  Walter Wiesendanger ,  Nico Cerletti ,  Clemens Sorg ,  Christiane DeWolf-Peeters ,  Jan Delabie

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  C12N5/00 ,  C07H15/12 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K14/52 ,  C07K16/24 ,  C07K16/3061 ,  A61K38/00

摘要： The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

摘要翻译： 本发明涉及具有约160kD的表观分子量的多肽，其是炎症介质的介体或前体，其衍生物，例如突变体和片段，其制备方法，编码所述多肽的DNA和杂交载体以及转化的宿主细胞 使用这些杂交载体，对所述多肽或其衍生物和抗体衍生物特异性的多克隆和单克隆抗体以及炎性病症和霍奇金淋巴瘤的诊断和治疗方法。

公开(公告)号：US5702920A

公开(公告)日：1997-12-30

申请号：US508142

申请日：1995-07-27

申请人： Karel Gerrit Odink ,  Roger Clerc ,  Nico Cerletti ,  Josef Bruggen ,  Lajos Tarcsay ,  Clemens Sorg ,  Walter Wiesendanger

发明人： Karel Gerrit Odink ,  Roger Clerc ,  Nico Cerletti ,  Josef Bruggen ,  Lajos Tarcsay ,  Clemens Sorg ,  Walter Wiesendanger

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577

CPC分类号： C07K16/24 ,  C07K14/52 ,  C12N15/85 ,  A61K38/00 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/55 ,  C12N2830/702

摘要： The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for those polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to those polypeptides, and diagnostic methods for inflammatory conditions and cystic fibrosis.

摘要翻译： 本发明涉及与人巨噬细胞迁移抑制因子有关的多肽，特别是称为MRP-8和MRP-14的多肽，其制备方法，mRNA，DNA和编码那些多肽的杂交载体，用这种杂交载体转化的宿主，单克隆 和多克隆抗体，以及炎性病症和囊性纤维化的诊断方法。

公开(公告)号：US20100311758A1

公开(公告)日：2010-12-09

申请号：US12422632

申请日：2009-04-13

申请人： JAHANNES ROTH ,  CLEMENS SORG

发明人： JAHANNES ROTH ,  CLEMENS SORG

IPC分类号： A61K31/4985 ,  A61P29/00

CPC分类号： G01N33/53 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/4727 ,  G01N2333/52 ,  G01N2800/065

摘要： The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

摘要翻译： 本发明涉及一种用于诊断基于标记物CALGRANULIN C的炎性疾病的方法，特别是用于诊断炎性疾病的特定阶段和/或用于确定复发的风险和/或用于区分具有相似症状的疾病的所述方法，所述方法包括 （a）获得待诊断的哺乳动物体液或组织的生物样品的步骤; （b）确定所述生物样品中存在的CALGRANULIN C多肽和/或编码多肽的核酸的量和/或浓度; 和（c）将所述生物样品中确定的CALGRANULIN C多肽的量和/或浓度与对照样品中测定的CALGRANULIN C多肽的量和/或浓度进行比较和/或比较核酸的量和/或浓度 编码在所述生物样品中测定的CALGRANULIN C多肽与在对照样品中测量的编码CALGRANULIN C多肽的核酸的量和/或浓度，其中编码该多肽的CALGRANULIN C多肽和/或核酸的量的差异指示 要诊断的疾病的阶段。

公开(公告)号：US20050147972A1

公开(公告)日：2005-07-07

申请号：US10504299

申请日：2003-02-17

申请人： Johannes Roth ,  Clemens Sorg

发明人： Johannes Roth ,  Clemens Sorg

IPC分类号： G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68

CPC分类号： G01N33/53 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/4727 ,  G01N2333/52 ,  G01N2800/065

摘要： The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed.

摘要翻译： 本发明涉及一种用于诊断基于标记物CALGRANULIN C的炎性疾病的方法，特别是用于诊断炎性疾病的特定阶段和/或用于确定复发的风险和/或用于区分具有相似症状的疾病的所述方法，所述方法包括 （a）获得待诊断的哺乳动物体液或组织的生物样品的步骤; （b）确定所述生物样品中存在的CALGRANULIN C多肽和/或编码多肽的核酸的量和/或浓度; 和（c）将所述生物样品中确定的CALGRANULIN C多肽的量和/或浓度与对照样品中测定的CALGRANULIN C多肽的量和/或浓度进行比较和/或比较核酸的量和/或浓度 编码在所述生物样品中测定的CALGRANULIN C多肽与在对照样品中测量的编码CALGRANULIN C多肽的核酸的量和/或浓度，其中编码该多肽的CALGRANULIN C多肽和/或核酸的量的差异指示 要诊断的疾病的阶段。

公开(公告)号：US5350687A

公开(公告)日：1994-09-27

申请号：US617485

申请日：1990-11-21

申请人： Karel G. Odink ,  Roger Clerc ,  Nico Cerletti ,  Josef Bruggen ,  Lajos Tarcsay ,  Clemens Sorg ,  Walter Wiesendanger

发明人： Karel G. Odink ,  Roger Clerc ,  Nico Cerletti ,  Josef Bruggen ,  Lajos Tarcsay ,  Clemens Sorg ,  Walter Wiesendanger

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K5/00 ,  C07K15/28 ,  C12N5/12

CPC分类号： C07K16/24 ,  C07K14/52 ,  C12N15/85 ,  A61K38/00 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/55 ,  C12N2830/702

摘要： The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for said polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to said polypeptides , and diagnostic methods for inflammatory conditions and cystic fibrosis.

摘要翻译： 本发明涉及与人巨噬细胞迁移抑制因子有关的多肽，特别是称为MRP-8和MRP-14的多肽，其制备方法，mRNA，DNA和编码所述多肽的杂交载体，用这种杂交载体转化的宿主，单克隆 和针对所述多肽的多克隆抗体，以及炎性病症和囊性纤维化的诊断方法。