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公开(公告)号：US20080124663A1
公开(公告)日：2008-05-29
申请号：US11983425
申请日：2007-11-08
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
IPC分类号： G03F7/38
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
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公开(公告)号：US07323143B2
公开(公告)日：2008-01-29
申请号：US10303642
申请日：2002-11-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , Justin Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , Justin Cooper McDonald , George M. Whitesides
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
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3.发明申请公开(公告)号：US20080122140A1
公开(公告)日：2008-05-29
申请号：US11983405
申请日：2007-11-08
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
IPC分类号： B29C35/08
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
摘要翻译： 本发明在某些实施方案中提供了改进的微流体系统和用于制造包含一个或多个微流体通道水平的改进的微流体系统的方法。 本发明的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。 根据本发明提供的微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括跨过网络的其它通道的通道，而在交叉点处没有物理交叉点。 本发明的微流体网络可以通过本发明提供的复制模制工艺，利用模具主体，其包括具有通过光刻形成的拓扑特征的表面。 在一些情况下，本发明的微流体网络由单个复制模制层组成，并且在其它情况下由两个，三个或更多个复制模制层组成，以形成整个微流体网络结构。 本发明还描述了使用本发明提供的微流体网络结构的各种新颖应用。
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4.发明授权Valves and pumps for microfluidic systems and method for making microfluidic systems 有权用于微流体系统的阀门和泵以及用于制造微流体系统的方法公开(公告)号：US07942160B2
公开(公告)日：2011-05-17
申请号：US10867151
申请日：2004-06-14
申请人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , J. Cooper McDonald , Steven J. Metallo , Howard A. Stone
发明人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , J. Cooper McDonald , Steven J. Metallo , Howard A. Stone
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B01L2400/0611 , B01L2400/0638 , B01L2400/0677 , F04B43/043 , F16K99/0001 , F16K99/0007 , F16K99/0015 , F16K99/003 , F16K99/0034 , F16K99/0048 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , F16K2099/0094 , Y10T137/0497 , Y10T137/7891 , Y10T137/7895 , Y10T137/791 , Y10T137/87917
摘要： The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction and inhibiting fluid flow in a second direction and may be practiced with the valves of the present invention.
摘要翻译： 本发明涉及微流体系统，包括用于微流体系统的阀和泵。 本发明的阀门包括止回阀，例如隔膜阀和活门阀。 本发明的其它阀包括一次性阀。 本发明的泵包括储存器和至少两个止回阀。 储层可能是可变的体积。 本发明还涉及柔性微流体系统。 本发明还涉及制造包括本发明的微流体系统的方法。 该方法包括在母版上形成微流体系统，将支撑物连接到微流体系统并从母体移除微流体系统。 载体可以保持连接到微流体系统，或者微流体系统可以被转移到另一个基底。 本发明还涉及一种操纵微流体系统中流体流动的方法。 该方法包括启动在第一方向上的流体流动并阻止在第二方向上的流体流动，并且可以用本发明的阀来实施。
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公开(公告)号：US06645432B1
公开(公告)日：2003-11-11
申请号：US09578589
申请日：2000-05-25
申请人： Janelle R. Anderson , Oksana Cherniavskaya , Daniel T. Chiu , Rebecca J. Jackman , Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Oksana Cherniavskaya , Daniel T. Chiu , Rebecca J. Jackman , Cooper McDonald , George M. Whitesides
IPC分类号： B01L302
CPC分类号： B01L3/0258 , B01F13/0059 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/405 , B29C33/424 , B29C39/02 , B29C39/24 , B29C66/7373 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/034 , B81C2201/036 , B82Y30/00 , Y10T137/2191 , Y10T137/2224 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
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