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公开(公告)号：US20250130199A1
公开(公告)日：2025-04-24
申请号：US18722014
申请日：2022-12-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Nicholas G. Bloomfield , Igor CHERNUSHEVICH , Yves LE BLANC
IPC: G01N27/623 , G01N27/624 , H01J49/06 , H01J49/24
Abstract: Methods and systems for performing differential mobility spectrometry-mass spectrometry (DMS-MIS) are provided herein. In various aspects, methods and systems described may be effective to improve the performance of a differential mobility spectrometry device and a MS device operating in tandem relative to conventional systems for DMS-MS. In certain aspects, methods and systems in accordance with the present teachings utilize an ion guide which comprises a multipole rod set and a plurality of auxiliary electrodes to which a DC voltage is applied during transmission of ions through the ion guide so as to generate an axial electric field along a longitudinal axis of the ion guide to accelerate the ions toward the outlet end of the ion guide. This may significantly reduce a pause duration between the application of different compensation voltage values without substantially increasing the likelihood of contamination or cross-talk between groups of ions transmitted by the differential mobility spectrometry device at each compensation voltage value.
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公开(公告)号：US20250125134A1
公开(公告)日：2025-04-17
申请号：US18688392
申请日：2022-09-02
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Chang LIU , Thomas R. COVEY
IPC: H01J49/00
Abstract: Methods and systems for automatically analyzing a collection of samples, the method including ionizing a plurality of samples, capturing a plurality of raw mass spectra for the ionized plurality of samples, correlating captured respective subsets of the raw mass spectra to each sample of the plurality of samples, and for each sample of the plurality of samples, generating a reconstructed mass spectrum based on the respective subset of the raw mass spectra of the sample. Methods and systems also include correlating the captured respective subsets of the raw mass spectra to each sample by generating a chronogram, and correlating a timeline of a sampling of the sample with the chronogram to correlate the captured respective subsets of the raw mass spectra to each sample. Methods and systems also include analyzing the generated reconstructed mass spectrum for each sample of the plurality of samples.
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公开(公告)号：US12243737B2
公开(公告)日：2025-03-04
申请号：US17754968
申请日：2020-09-29
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： James Hager
IPC: H01J49/42
Abstract: In various aspects, methods and systems disclosed herein are capable of operating a Fourier Transform Mass Spectrometry (FTMS) quadrupole mass analyzer in two operational modes: transmitting mode and trapping mode. In the trapping mode, ions are first trapped and cooled within the FTMS quadrupole mass analyzer prior to being subjected to an excitation pulse and ejected from the FTMS quadrupole mass analyzer for detection. However, in transmitting mode, the FTMS quadrupole mass analyzer may provide more rapid analysis because the excitation pulse is applied to the ions of an ion beam that is being continuously transmitted through the FTMS quadrupole mass analyzer.
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公开(公告)号：US20250069877A1
公开(公告)日：2025-02-27
申请号：US18718871
申请日：2022-12-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Mircea GUNA , William LOYD
IPC: H01J49/06
Abstract: A method of performing mass spectrometry is disclosed. which comprises introducing a plurality of ions into an ion guide of a mass spectrometer via an inlet orifice thereof. where the ion guide includes a plurality of rods arranged in a multipole configuration and spaced from one another to provide a passageway for transit of the ions therethrough. applying RF voltages to the rods so as to generate an electromagnetic field within the passageway for providing radial confinement of the ions passing through the passageway, identifying a space charge effect, which can adversely affect operation of the mass spectrometer, based on detection of a variation of an intensity of an ion detection signal associated with at least one ion population transmitted through said ion guide and having an m/z ratio greater than a threshold, and in response to said identification of the adverse space charge effect. adjusting at least one of frequency and amplitude of the RF voltages to counteract said space charge effect.
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公开(公告)号：US20250069873A1
公开(公告)日：2025-02-27
申请号：US18725973
申请日：2022-12-22
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Gordana IVOSEV , Chang LIU , David M. COX
IPC: H01J49/00
Abstract: A method and system for detecting a signal measurement error, the method including providing a well plate including error correction wells and sample wells, each sample well including a single sample, and each error correction well including a mixture of samples from two or more sample wells. The method includes receiving an aliquot from the wells at a sample receiver, measuring a signal for the received aliquot, calculating an expected signal for each of the error correction wells, comparing the measured signal to the calculated expected signal for each error correction well, and determining whether an error exists in the signal of at least one sample well. When the error exists, the method correlates the error to one or more sample wells.
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Patent Agency Ranking
公开(公告)号：US20250067617A1
公开(公告)日：2025-02-27
申请号：US18718916
申请日：2022-12-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Amit PATEL , Aaron STELLA
IPC: G01M3/20
Abstract: Leak detection systems and methods in accordance with various aspects of the present teachings can, in various embodiments, sequester fluid leaking from the interface between a sample source and the inlet of the ion source, alert an operator as to a leak condition, and/or automatically terminate the experiment. In various aspects, a liquid leak detection system is accordance with the present teachings comprises a collection basin configured to couple to a proximal end of a conduit in fluid communication with a discharge end of an ion source of a mass spectrometer such that the proximal end of the conduit extends through the internal volume of the basin. The system may also comprise a drainage tube having an inlet end opening into an internal volume of the collection basin and configured to drain liquid therefrom, a sensor disposed within the basin or the drainage tube and configured to generate a signal indicative of liquid therewithin, and a processor that is configured to cause a user to be alerted and/or cause an experiment to be terminated upon receiving from the sensor a signal indicative of a leak.
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公开(公告)号：US20250027950A1
公开(公告)日：2025-01-23
申请号：US18630611
申请日：2024-04-09
Inventor： Aaron Hudson , Takayuki Mizutani , Subhasish Purkayastha , Thomas W. Roscoe
IPC: G01N33/68 , G01N27/624 , H01J49/00 , H01J49/02
Abstract: An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.
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公开(公告)号：US20240395528A1
公开(公告)日：2024-11-28
申请号：US18693363
申请日：2022-09-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Robert HAUFLER , William LOYD
Abstract: In one aspect, a mass spectrometer is disclosed, which includes an ion path along which an ion beam can propagate, and an ion beam deflector positioned in the ion path and configured to modulate transfer of an ion beam received from an upstream section of the ion path to a downstream section thereof, said ion beam deflector comprising at least one electrically conductive electrode positioned relative to one another to provide an opening through which the ion beam can pass, where the two electrodes are electrically insulated relative to one another so as to allow maintaining each electrode at a DC potential independent of a DC potential at which the other electrode is maintained.
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9.发明授权公开(公告)号：US12135969B2
公开(公告)日：2024-11-05
申请号：US17261811
申请日：2019-07-19
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu , Stanislaw Potyrala , Alex Tsipirovich
Abstract: Electromagnetic systems and corresponding methods for assembling the electromagnetic systems are described. The electromagnetic systems can be used in fluid processing systems that include a plurality of fluid containers, each configured to define a fluid chamber that receives a fluid and a plurality of magnetic particles, and a plurality of electromagnets configured to generate a magnetic field within at least one of the plurality of the fluid containers. The fluid processing system can also include a PCB board that supplies the electromagnets with electrical current by establishing an electrical connection between electrical contact terminals included on the PCB board and spring loaded connections included on each electromagnet. A control component controls the electromagnetic field generated by each electromagnet to generate a plurality of magnetic field gradients within the at least one fluid container sufficient to magnetically influence the plurality of magnetic particles within the fluid in each fluid container.
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公开(公告)号：US20240355612A1
公开(公告)日：2024-10-24
申请号：US18685356
申请日：2022-08-23
Applicant: DH Technologies Development Pte. Ltd.
Inventor： David M. COX , Manuel FAUR , Mircea GUNA , Yang KANG , Andrei SONOC
CPC classification number: H01J49/4215 , H01J49/004
Abstract: In one aspect, an ion filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to provide an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto. At least two pairs of auxiliary electrodes are interspersed between the plurality of rods and are configured for application of a DC bias voltage with one polarity to one of said pairs and a DC bias voltage with an opposite polarity to the other one of said pairs to provide a DC potential difference between the auxiliary electrodes and the plurality of rods.
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