公开(公告)号：US20150258342A1

公开(公告)日：2015-09-17

申请号：US14667931

申请日：2015-03-25

申请人： Yuval Mika ,  Darren Sherman ,  Robert S. Schwartz ,  Robert A. Van Tassel ,  Daniel Burkhoff

发明人： Yuval Mika ,  Darren Sherman ,  Robert S. Schwartz ,  Robert A. Van Tassel ,  Daniel Burkhoff

IPC分类号： A61N1/365

CPC分类号： A61N1/36564 ,  A61F2/2412 ,  A61F2/2424 ,  A61F2250/0013 ,  A61N1/36117 ,  A61N1/36514 ,  A61N1/36528 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

摘要： Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

摘要翻译： 公开了通过控制心房压力和心房伸展来控制血压的系统和方法。 在一些实施例中，刺激电路可以被配置为将刺激脉冲传送到患者心脏的至少一个心室，并且至少一个控制器可以被配置为执行刺激脉冲的一个或多个刺激模式的传送到 至少一个心室，其中所述刺激脉冲中的至少一个刺激心脏使得由心房的心房收缩引起的心房压力在时间上与心房的被动压力积聚重叠，使得心房的心房压力 由刺激引起的是由心房收缩和被动压力积聚引起的心房压力的组合，并且高于心房的心房压力将没有刺激，并且使得患者的血压降低。

公开(公告)号：US08790267B2

公开(公告)日：2014-07-29

申请号：US12673037

申请日：2008-08-11

申请人： Hanan Keren ,  Yoav Avidor ,  Pierre Squara ,  Daniel Burkhoff ,  Baruch Levy

发明人： Hanan Keren ,  Yoav Avidor ,  Pierre Squara ,  Daniel Burkhoff ,  Baruch Levy

IPC分类号： A61B5/02 ,  A61B5/026 ,  A61B5/029

CPC分类号： A61B5/02028 ,  A61B5/029 ,  A61B5/053 ,  A61B5/0535 ,  A61B5/0537 ,  A61B5/4869 ,  A61B5/7239 ,  A61B5/725 ,  A61B5/742

摘要： A method of processing a signal pertaining to at least one electrical property of an organ of a subject is disclosed. The method comprises determining a physiological condition of the subject, selecting a frequency band, filtering the signal according to the frequency band, and dynamically adapting the frequency band in response to a change in the physiological condition.

摘要翻译： 公开了处理与被检体的器官的至少一个电气特性有关的信号的方法。 该方法包括确定对象的生理状况，选择频带，根据频带对信号进行滤波，以及响应于生理状态的变化来动态调整频带。

公开(公告)号：US6076013A

公开(公告)日：2000-06-13

申请号：US231022

申请日：1999-01-14

申请人： Edward F. Brennan ,  Daniel Burkhoff

发明人： Edward F. Brennan ,  Daniel Burkhoff

IPC分类号： A61F2/00 ,  A61F2/24 ,  A61N1/362 ,  A61N1/368 ,  A61N1/36

CPC分类号： A61F2/2481 ,  A61N1/3627 ,  A61N1/368

摘要： Apparatus and method for the treatment of congestive heart failure are disclosed that utilize a cuff that surrounds the heart and constrains cardiac dilation, while electrodes embedded in the cuff stimulate the myocardium to contractile function. An EKG signal can be processed to create an optimal pattern of selective stimulation of different areas of the heart at different times. An implantable circuit contains a power source and stimulation circuits. In some embodiments, a telemetry unit and an EKG collection circuit are also included. In accordance with the present disclosure, cuff limits the dilation of the heart and the stimulation electrodes enhance ventricular function by optimizing ventricular contractility.

摘要翻译： 公开了用于治疗充血性心力衰竭的装置和方法，其利用围绕心脏的袖带并约束心脏扩张，而嵌入袖带中的电极刺激心肌收缩功能。 可以处理EKG信号以在不同时间创建心脏不同区域的选择性刺激的最佳模式。 可植入电路包含电源和刺激电路。 在一些实施例中，还包括遥测单元和EKG采集电路。 根据本公开，袖带限制心脏的扩张，并且刺激电极通过优化心室收缩力来增强心室功能。

公开(公告)号：US20120041508A1

公开(公告)日：2012-02-16

申请号：US13265874

申请日：2010-04-23

申请人： Benny Rousso ,  Yuval Mika ,  Shlomo Ben-Haim ,  Daniel Burkhoff ,  David Prutchi

发明人： Benny Rousso ,  Yuval Mika ,  Shlomo Ben-Haim ,  Daniel Burkhoff ,  David Prutchi

IPC分类号： A61N1/372 ,  A61N1/08

CPC分类号： A61N1/025 ,  A61N1/05 ,  A61N1/08 ,  A61N1/362 ,  A61N1/372 ,  A61N1/3752 ,  A61N1/378 ,  A61N1/3785 ,  A61N1/3962

摘要： An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.

摘要翻译： 一种可植入引线连接器，其被配置为长期植入并且电连接多个医疗装置并且在所述互连装置与目标器官之间引导电信号，包括：第一端口，适于接收适于刺激靶组织的第一信号;第二端 适于接收适合于刺激目标组织的第二信号的端口以及被配置为连接到目标器官的第三端口，其中所述第一和第二端口中的至少一个被配置为连接到未与所述连接器集成的信号发生器。

公开(公告)号：US06267757B1

公开(公告)日：2001-07-31

申请号：US08942874

申请日：1997-10-02

申请人： Michael Aita ,  Daniel Burkhoff ,  Noriyoshi Yamamoto ,  Miriam H. Taimisto ,  Kenneth P. Aron ,  Christopher J. Danek

发明人： Michael Aita ,  Daniel Burkhoff ,  Noriyoshi Yamamoto ,  Miriam H. Taimisto ,  Kenneth P. Aron ,  Christopher J. Danek

IPC分类号： A61B1739

CPC分类号： A61B18/1492 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2018/00839

摘要： The invention is directed to an intracorporeal device for myocardial revascularization of a patient's heart tissue by at least one burst of RF energy over an interval of about 1 to about 500 msec, preferably about 30 to about 130 msec. The intracorporeal device has an elongated insulated, electrical conducting shaft with an uninsulated distal tip which is configured to emit RF energy. The uninsulated distal tip has a diameter of about 0.025 to about 0.2 inch, preferably about 0.04 to about 0.08 inch and a length of about 0.1 to about 5 mm, preferably about 1.5 to about 3.5 mm.

摘要翻译： 本发明涉及用于在约1至约500毫秒，优选约30至约130毫秒的间隔的至少一个RF能量的突发的患者心脏组织心肌血运重建的体内装置。 体内器件具有细长绝缘的导电轴，其具有未绝缘的远端，其构造成发射RF能量。 未绝缘的远侧末端具有约0.025至约0.2英寸，优选约0.04至约0.08英寸的直径和约0.1至约5mm的长度，优选约1.5至约3.5mm的直径。

公开(公告)号：US06179793B2

公开(公告)日：2001-01-30

申请号：US09006823

申请日：1998-01-14

申请人： Neil S. Rothman ,  Mark Gelfand ,  Daniel Burkhoff ,  Myron L. Weisfeldt

发明人： Neil S. Rothman ,  Mark Gelfand ,  Daniel Burkhoff ,  Myron L. Weisfeldt

IPC分类号： A61H3100

CPC分类号： A61H31/005 ,  A61H9/0078 ,  A61H31/006 ,  A61H2031/025 ,  A61H2201/0103 ,  A61H2201/1238 ,  A61H2201/165 ,  A61H2201/5007 ,  A61H2205/08 ,  A61H2230/04

摘要： A method is disclosed for inflating an inflatable vest to assist the heart in patients suffering from heart failure. The inflation of the vest is synchronized with on-set of the systole phase of the heart, when the left ventricular compresses to force blood out of the heart and through the aorta. The inflated vest compresses the patient's chest and increases the intrathoracic pressure. This increase in pressure assists the heart in moving blood out of the heart and through the aorta. In addition, the vest is arranged to leave the patient's abdomen free of restraint so that the increase in intrathoracic pressure due to the vest moves blood into the abdomen, and to allow the abdomen to dynamically recoil in response to the vest inflation. In addition, ECG signals from electrodes applied to the patient are processed to trigger the vest inflation in real time with the current heartbeat cycle, such that the vest inflation is triggered when the heart begins to contract. A controller provides an adjustable signal blanking period to avoid noise components following the QRS complex.

摘要翻译： 公开了一种用于充气充气背心以帮助心脏患有心力衰竭的患者的方法。 背心的通货膨胀与心脏的心脏收缩阶段的同步，当左心室压迫以迫使血液从心脏和通过主动脉。 充气背心压缩患者的胸部并增加胸内压力。 这种压力的增加有助于心脏将血液从心脏和主动脉中移出。 另外，该背心被安排为使得患者腹部不受约束，使得由于背心引起的胸内压力的增加使血液进入腹部，并且允许腹部响应于背心通气而动态地反冲。 另外，通过当前心跳周期处理施加到患者的电极的ECG信号，以实时触发背心通气，从而当心脏开始收缩时引发背心通气。 控制器提供可调整的信号消隐周期，以避免QRS波段后面的噪声分量。

公开(公告)号：US08706230B2

公开(公告)日：2014-04-22

申请号：US13265874

申请日：2010-04-23

申请人： Benny Rousso ,  Yuval Mika ,  Shlomo Ben-Haim ,  Daniel Burkhoff ,  David Prutchi

发明人： Benny Rousso ,  Yuval Mika ,  Shlomo Ben-Haim ,  Daniel Burkhoff ,  David Prutchi

IPC分类号： A61N1/372 ,  A61N1/08

CPC分类号： A61N1/025 ,  A61N1/05 ,  A61N1/08 ,  A61N1/362 ,  A61N1/372 ,  A61N1/3752 ,  A61N1/378 ,  A61N1/3785 ,  A61N1/3962

摘要： An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.

摘要翻译： 一种可植入引线连接器，其被配置为长期植入并且电连接多个医疗装置并且在所述互连装置与目标器官之间引导电信号，包括：第一端口，适于接收适于刺激靶组织的第一信号;第二端 适于接收适合于刺激目标组织的第二信号的端口以及被配置为连接到目标器官的第三端口，其中所述第一和第二端口中的至少一个被配置为连接到未与所述连接器集成的信号发生器。

公开(公告)号：US20110178418A1

公开(公告)日：2011-07-21

申请号：US13120159

申请日：2009-09-22

申请人： Yoav Avidor ,  Baruch Levy ,  Dan Avidor ,  Daniel Burkhoff

发明人： Yoav Avidor ,  Baruch Levy ,  Dan Avidor ,  Daniel Burkhoff

IPC分类号： A61B5/026

CPC分类号： A61B5/0245 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/053 ,  A61B5/7207 ,  A61B5/7239 ,  G16H40/63

摘要： A method of diagnosis is disclosed. The method comprises: acquiring an absolute component and a phase component of an input signal indicative of an impedance of an organ of a subject; determining baseline blood flow of the subject based on the phase component; determining transient changes in blood flow based on at least the absolute component; and displaying the baseline blood flow and the transient changes in blood flow.

摘要翻译： 公开了一种诊断方法。 该方法包括：获取指示被检体器官的阻抗的输入信号的绝对分量和相位分量; 基于相位分量确定受试者的基线血流; 基于至少绝对分量确定血流的瞬时变化; 并显示基线血流量和血流瞬时变化。

公开(公告)号：US20100191127A1

公开(公告)日：2010-07-29

申请号：US12527697

申请日：2008-02-21

申请人： Hanan Keren ,  Daniel Burkhoff ,  Yoav Avidor ,  Pierre Squara

发明人： Hanan Keren ,  Daniel Burkhoff ,  Yoav Avidor ,  Pierre Squara

IPC分类号： A61B5/0205

CPC分类号： A61B5/0535 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/029 ,  A61B5/0537 ,  A61B5/4869

摘要： A method of estimating exercise capacity of a subject is disclosed. The method uses output radiofrequency signals transmitted to the subject during exercise and input radiofrequency signals received from the subject during exercise. The method comprises: determining a phase shift of the input radiofrequency signals relative to the output radiofrequency signals; calculating cardiac output based on the phase shift; and using the cardiac output for estimating the exercise capacity of the subject.

摘要翻译： 公开了一种估计受试者运动能力的方法。 该方法使用在运动期间发送到被摄体的输出射频信号，并且在运动期间输入从对象接收的射频信号。 该方法包括：确定输入射频信号相对于输出射频信号的相移; 基于相移计算心输出量; 以及使用心输出量来估计受试者的运动能力。

公开(公告)号：US08764667B2

公开(公告)日：2014-07-01

申请号：US12450022

申请日：2008-03-06

申请人： Yoav Avidor ,  Daniel Burkhoff ,  Pierre Squara ,  Hanan Keren

发明人： Yoav Avidor ,  Daniel Burkhoff ,  Pierre Squara ,  Hanan Keren

IPC分类号： A61B5/02

CPC分类号： A61B5/0535 ,  A61B5/029 ,  A61B5/145 ,  A61B5/4818

摘要： A method of monitoring sleep of a sleeping subject is disclosed. The method comprises determining a phase shift of input radiofrequency signals received from the subject during sleep relative to output radiofrequency signals transmitted to the subject during sleep, calculating cardiac output based on the phase shift, and using the cardiac output for identifying sleep apnea events.

摘要翻译： 公开了一种监测睡眠对象睡眠的方法。 所述方法包括：确定在休眠期间从睡眠期间对象接收的输入射频信号相对于在睡眠期间发送给对象的输出射频信号的相移，基于相移计算心输出量，以及使用心输出量来识别睡眠呼吸暂停事件。