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    FUNGAL SIGNALLING AND METABOLIC ENZYMES
    3.
    发明申请
    FUNGAL SIGNALLING AND METABOLIC ENZYMES 审中-公开
    真菌信号和代谢酶

    公开(公告)号：US20110081348A1

    公开(公告)日：2011-04-07

    申请号：US11720664

    申请日：2005-12-01

    申请人： Nina Brogden ,  Michael John Bromley ,  Paul David Carr ,  Sarah Jane Kaye ,  Jason David Oliver ,  Daniel Scott Tuckwell

    发明人： Nina Brogden ,  Michael John Bromley ,  Paul David Carr ,  Sarah Jane Kaye ,  Jason David Oliver ,  Daniel Scott Tuckwell

    IPC分类号： A61K39/395 ,  C07K16/14 ,  A61K31/7088 ,  A61K38/48 ,  A01N63/02 ,  A01N37/18 ,  A01P3/00 ,  A61P31/10 ,  G01N33/53 ,  C12N15/63 ,  C07H21/00 ,  C12N9/88 ,  C12N1/14 ,  C12N1/15 ,  C12N1/21

    CPC分类号： C12N9/88 ,  C07K14/38 ,  C12Q1/18

    摘要： Method of identifying an anti-fungal agent which targets as an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 50, 53, 56, 59, 61 or 63, or (ii) a protein which has 60% identity with (i), or (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, or (iv) a polynucleotide that comprises a sequence which encodes (i), (ii) or (iii), or (v) a polynucleotide comprising a sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.

    摘要翻译： 鉴定靶向作为真菌的必需蛋白质或基因的抗真菌剂的方法，包括使候选物质与（i）包含SEQ ID NO：3,6,9,12,15， 18,21,24,27,30,33,36,39,42,45,48,50,53,56,59,61或63，或（ii）与（i）具有60％同一性的蛋白质， 或（iii）包含（i）或（ii）的片段的蛋白质，所述片段具有至少50个氨基酸的长度，或（iv）包含编码（i），（ii）或（ iii）或（v）多核苷酸，其包含与（iv）的编码序列具有至少70％同一性的序列，并确定候选物质是否结合或调节（i），（ii），（iii），（ iv）或（v），其中（i），（ii），（iii），（iv）或（v）的结合或调节表明候选物质是抗真菌剂。

    2031 Oxidoreductase
    4.
    发明申请
    2031 Oxidoreductase 审中-公开
    2031氧化还原酶

    公开(公告)号：US20080206220A1

    公开(公告)日：2008-08-28

    申请号：US10590171

    申请日：2005-02-18

    申请人： Sandra Elizabeth Lavens ,  Jason David Oliver ,  John Leslie Thain ,  Daniel Scott Tuckwell ,  Michael John Bromley

    发明人： Sandra Elizabeth Lavens ,  Jason David Oliver ,  John Leslie Thain ,  Daniel Scott Tuckwell ,  Michael John Bromley

    IPC分类号： A61K38/44 ,  C12Q1/68 ,  C12Q1/26 ,  C12N9/02 ,  C07H21/00 ,  A61K31/7088 ,  C12N15/00 ,  C12N5/00 ,  C07K16/00 ,  C12N1/15

    CPC分类号： C12Q1/26 ,  C12Q1/18 ,  G01N2333/37 ,  G01N2333/90209 ,  G01N2500/02

    摘要： Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a NADH:flavin oxidoreductase protein which comprises the sequence shown by SEQ ID NO:3, (ii) a NADH:flavin oxidoreductase protein which is a homologue of (i) and which comprises the sequence shown by SEQ ID NO: 8, 12, 14, 19, 24, 42, 44, 83 or 85, (iii) a protein which has 50% identity with (i) or (ii), (iv) a protein comprising a fragment of (i), (ii) or (iii) which fragment has a length of at least 50 amino acids, (v) a polynucleotide that comprises sequence which encodes (i), (ii), (iii) or (iv), (vi) a polynucleotide comprising sequence which has at least 70% identity with the coding sequence of (v), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), (v) or (vi), wherein binding or modulation of (i), (ii), (iii), (iv), (v) or (vi) indicates that the candidate substance is an anti-fungal agent.

    摘要翻译： 鉴定靶向真菌的必需蛋白质或基因的抗真菌剂的方法，包括使候选物质与（i）包含SEQ ID NO：3所示序列的NADH：黄素氧化还原酶蛋白质接触，（ii）NADH ：（i）的同系物的黄素氧化还原酶蛋白，其包含SEQ ID NO：8,12,14,19,24,42,44,83或85所示的序列，（iii）具有50％ 与（i）或（ii）的同一性，（iv）包含（i），（ii）或（iii）的片段的蛋白质，该片段长度为至少50个氨基酸，（v）包含序列 其编码（i），（ii），（iii）或（iv），（vi）包含与（v）的编码序列具有至少70％同一性的序列的多核苷酸，并确定候选物质是否结合或调节 （i），（ii），（iii），（iv），（v）或（vi）中的（i），（ii），（iii） vi）表示候选物质是抗真菌剂。