公开(公告)号：US20110106120A1

公开(公告)日：2011-05-05

申请号：US12863030

申请日：2009-01-16

Applicant: Kenneth Haselby ,  Brian D. Choules ,  Blayne A. Roeder ,  Richard B. Sisken ,  David Eric Orr ,  James D. Purdy ,  Steven J. Charlebois ,  David D. Grewe ,  Neal E. Fearnot ,  Alan R. Leewood

Inventor： Kenneth Haselby ,  Brian D. Choules ,  Blayne A. Roeder ,  Richard B. Sisken ,  David Eric Orr ,  James D. Purdy ,  Steven J. Charlebois ,  David D. Grewe ,  Neal E. Fearnot ,  Alan R. Leewood

IPC: A61B17/11

CPC classification number: A61M1/125 ,  A61B5/076 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/6862 ,  A61B5/6876 ,  A61B5/6882 ,  A61F2/0077 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2/86 ,  A61F2002/068 ,  A61F2002/8486 ,  A61F2220/0016 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0071 ,  A61F2230/008 ,  A61M1/1006 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1098 ,  A61M1/122 ,  A61M1/3653 ,  A61M1/3659

Abstract: An attachment system for attaching an intravascular device to a vessel wall of a body vessel is disclosed. The attachment system includes a tubular expandable body defining a lumen therethrough. The tubular expandable body is configured to move between an expanded state to contact the body vessel and a collapsed state for delivery or retrieval. The tubular expandable body is configured to contact the vessel wall along the length of the tubular expandable body in the expanded state when deployed in the body vessel. An intravascular device is held to the exterior side of the tubular expandable body and is configured to contact the vessel wall when the tubular expandable body is in the expanded state and the system is deployed within a body vessel.

Abstract translation: 公开了一种用于将血管内装置附接到身体血管的血管壁的附接系统。 附接系统包括限定通过其中的腔的管状可扩张体。 管状可膨胀体构造成在膨胀状态下与身体容器接触并且用于输送或取出的折叠状态。 管状可膨胀体构造成当展开在身体容器中时，处于膨胀状态的管状可膨胀体的长度的容器壁接触。 血管内装置被保持在管状可膨胀体的外侧，并且构造成当管状可膨胀体处于膨胀状态并且系统部署在体内容器内时与血管壁接触。

公开(公告)号：US07828840B2

公开(公告)日：2010-11-09

申请号：US12291593

申请日：2008-11-12

Applicant: David Paul Biggs ,  David D. Grewe ,  Anthony O. Ragheb ,  Patrick H. Ruane

Inventor： David Paul Biggs ,  David D. Grewe ,  Anthony O. Ragheb ,  Patrick H. Ruane

IPC: A61F2/06 ,  A61F13/00

CPC classification number: A61F2/86 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: This invention relates to medical devices and an angiotensin II type 2 (AT2) receptor antagonist compound, the medical device being adapted to release the AT2 receptor antagonist compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.

Abstract translation: 本发明涉及医疗装置和血管紧张素II型2型（AT2）受体拮抗剂化合物，该医疗装置适于释放患者体内的AT2受体拮抗剂化合物。 本发明还涉及医疗装置和治疗疾病的方法，例如动脉瘤和主动脉夹层。 医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。

公开(公告)号：US07780717B2

公开(公告)日：2010-08-24

申请号：US11789840

申请日：2007-04-26

Applicant: Werner Dieter Ducke ,  David Ernest Hartley ,  David D. Grewe

Inventor： Werner Dieter Ducke ,  David Ernest Hartley ,  David D. Grewe

IPC: A61F2/06

CPC classification number: A61F2/95 ,  A61F2002/9517 ,  A61F2250/0065 ,  A61M25/0136

Abstract: A stent graft introducer actuation assembly (1) having a fixed handle (3) and at least one sliding handle (5, 7), the sliding handle or handles telescoping within the fixed handle, and a winch arrangement (9) to retract the sliding handle into the fixed handle. There may be provided arrangements to give a mechanical advantage to the winch arrangement.

Abstract translation: 一种具有固定手柄（3）和至少一个滑动手柄（5,7）的支架移植物导引器致动组件（1），所述滑动手柄或手柄在固定手柄内伸缩，以及绞盘装置（9） 处理固定手柄。 可以提供为绞盘装置提供机械优点的布置。

公开(公告)号：US20090105797A1

公开(公告)日：2009-04-23

申请号：US12250957

申请日：2008-10-14

Applicant: Blayne A. ROEDER ,  Alan R. Leewood ,  David D. Grewe

Inventor： Blayne A. ROEDER ,  Alan R. Leewood ,  David D. Grewe

IPC: A61F2/86

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91558 ,  A61F2230/0054

Abstract: A stent includes a radially expandable tubular structure having a first end, a second end, and a primary strut arrangement extending over substantially an entire length thereof. The primary strut arrangement includes a plurality of rows of struts. The struts are interconnected within each row in a sinusoidal arrangement about a circumference of the tubular structure. Crests and troughs in the sinusoidal arrangement include connection points of the struts. A plurality of longitudinal struts connect neighboring rows of struts at the connection points. In each row, four circumferentially adjacent struts are disposed between every two longitudinal struts joined to the row. One of the two longitudinal struts extends in a direction of the first end to a first neighboring row, and the other of the two longitudinal struts extends in a direction of the second end to a second neighboring row.

Abstract translation: 支架包括具有在其基本上整个长度上延伸的第一端，第二端和主支柱装置的径向可扩张管状结构。 主支柱装置包括多排支柱。 支柱在每排内以围绕管状结构的圆周的正弦配置相互连接。 正弦曲线布置的波峰和波谷包括支柱的连接点。 多个纵向支柱在连接点处连接相邻的支柱排。 在每排中，四个周向相邻的支柱设置在连接到该行的每两个纵向支柱之间。 两个纵向支柱中的一个在第一端的方向上延伸到第一相邻行，并且两个纵向支柱中的另一个在第二端的方向上延伸到第二相邻行。

公开(公告)号：US20090099638A1

公开(公告)日：2009-04-16

申请号：US12236744

申请日：2008-09-24

Applicant: David D. Grewe

Inventor： David D. Grewe

IPC: A61F2/06 ,  A61B19/00

CPC classification number: A61F2/966 ,  A61B2017/00398 ,  A61F2002/9517

Abstract: A motorized delivery system and method for deploying an endoluminal prosthesis is disclosed. The system comprises a delivery device and an electrical drive system. The prosthesis is disposed between an inner dilator and an elongate sheath. To deploy the prosthesis, the electrical drive system is actuated. One or more gear-pulley arrangements rotate to cause retraction of the sheath in relation to the inner dilator.

Abstract translation: 公开了一种用于部署腔内假体的电动输送系统和方法。 该系统包括输送装置和电驱动系统。 假体设置在内部扩张器和细长护套之间。 为了部署假体，电驱动系统被致动。 一个或多个齿轮 - 滑轮装置旋转以引起护套相对于内部扩张器的缩回。

公开(公告)号：US09119742B2

公开(公告)日：2015-09-01

申请号：US12173277

申请日：2008-07-15

Applicant: Timothy A. Chuter ,  David D. Grewe ,  Blayne A. Roeder ,  Alan R. Leewood

Inventor： Timothy A. Chuter ,  David D. Grewe ,  Blayne A. Roeder ,  Alan R. Leewood

IPC: A61F2/966 ,  A61F2/95

CPC classification number: A61F2/966 ,  A61F2/95 ,  A61F2002/9517

Abstract: A device for delivering and deploying a prosthesis is described and comprises an elongate sheath having a sheath lumen and a delivery catheter slidably disposed within the sheath lumen. A deployment assist mechanism may be coupled to the delivery catheter and the sheath and configured to apply a retraction force to the delivery catheter and the sheath. Additional devices, systems, and methods of delivering and deploying a prosthesis are described.

Abstract translation: 描述了用于递送和展开假体的装置，并且包括具有鞘腔的细长护套和可滑动地设置在鞘腔内的输送导管。 部署辅助机构可以联接到输送导管和护套并且被配置为向递送导管和护套施加缩回力。 描述了递送和部署假体的附加装置，系统和方法。

公开(公告)号：US20120116503A1

公开(公告)日：2012-05-10

申请号：US13383567

申请日：2010-07-13

Applicant: David D. Grewe ,  Kenneth Haselby ,  Keith Milner

Inventor： David D. Grewe ,  Kenneth Haselby ,  Keith Milner

IPC: A61F2/82 ,  B23P11/00 ,  B23P25/00

CPC classification number: A61L31/14 ,  A61F2/07 ,  A61F2/89 ,  A61F2002/075 ,  A61L31/082 ,  Y10T29/49826 ,  Y10T29/49885

Abstract: The invention relates to medical device systems that include a delivery instrument comprising a sheath having an abluminal surface and a luminal surface; a radially-expandable frame disposed at least partially within the sheath, the frame having an abluminal surface at least partially in contact with the luminal surface of the sheath, and a luminal surface defining a sub-stantially cylindrical lumen; and a fine powder coating disposed on at least one of the abluminal surface of the frame and the luminal surface of the sheath. The invention also relates to methods of manufacturing, loading, and delivering the coated medical devices.

Abstract translation: 本发明涉及医疗装置系统，其包括输送器械，该输送器械包括具有腔内表面和腔表面的护套; 至少部分地设置在所述护套内的可径向扩张的框架，所述框架具有至少部分地与所述护套的所述管腔表面接触的腔内表面，以及限定基本上圆柱形的管腔的管腔表面; 以及细粉末涂层，其设置在框架的外侧表面和护套的管腔表面中的至少一个上。 本发明还涉及制造，加载和递送涂覆的医疗装置的方法。

公开(公告)号：US20080183268A1

公开(公告)日：2008-07-31

申请号：US11965385

申请日：2007-12-27

Applicant: Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees ,  Thomas G. Kozma ,  David D. Grewe ,  Darin G. Schaeffer ,  JiChao Sun

Inventor： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees ,  Thomas G. Kozma ,  David D. Grewe ,  Darin G. Schaeffer ,  JiChao Sun

IPC: A61F2/82

CPC classification number: A61F2/885 ,  A61F2/0077 ,  A61F2250/0068

Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

Abstract translation: 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

公开(公告)号：US20080033522A1

公开(公告)日：2008-02-07

申请号：US11782037

申请日：2007-07-24

Applicant: David D. Grewe ,  William D. Voorhees ,  Anthony O. Ragheb

Inventor： David D. Grewe ,  William D. Voorhees ,  Anthony O. Ragheb

IPC: A61F2/06

CPC classification number: A61L31/082

Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device can include a frame with a vessel-engaging region on at least a portion of the medical device. The vessel-engaging region may be a particulate coating configured and adapted to engage the interior wall of a body vessel or to attach a material, such as a valve leaflet or graft material, to the frame. Methods of making an implantable medical device and methods of treating a subject are also disclosed.

Abstract translation: 提供了用于植入体内的医疗装置及其使用和制造方法。 医疗装置可以包括在医疗装置的至少一部分上具有容器接合区域的框架。 容器接合区域可以是构造成适于接合身体容器的内壁或者将诸如阀瓣或移植材料的材料附接到框架的颗粒涂层。 还公开了制造可植入医疗装置的方法和治疗受试者的方法。

公开(公告)号：US08303648B2

公开(公告)日：2012-11-06

申请号：US11789413

申请日：2007-04-24

Applicant: David D. Grewe ,  James D. Purdy

Inventor： David D. Grewe ,  James D. Purdy

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0026 ,  A61F2230/0095 ,  A61F2250/0068

Abstract: The invention relates to a prosthetic valve for regulating flow through a body lumen and delivering a therapeutic agent into said lumen. In one embodiment, the prosthesis includes a frame having an exterior wall, a hollow interior space, a valve member, and at least one aperture through the exterior wall that permits a controlled amount of therapeutic agent loaded into the hollow interior into the surrounding body lumen following implantation. In another embodiment, the prosthesis includes a frame having a groove, a valve member, and therapeutic agent loaded in the groove.

Abstract translation: 本发明涉及一种用于调节通过体腔的流动并将治疗剂输送到所述内腔中的人造瓣膜。 在一个实施例中，假体包括具有外壁，中空内部空间，阀构件和穿过外壁的至少一个孔的框架，其允许将受控量的治疗剂装载到中空内部进入周围体腔 植入后。 在另一个实施例中，假体包括具有凹槽，阀构件和装载在凹槽中的治疗剂的框架。