公开(公告)号：US10087401B2

公开(公告)日：2018-10-02

申请号：US13422709

申请日：2012-03-16

申请人： David M. Lee ,  Jennifer L. Sims

发明人： David M. Lee ,  Jennifer L. Sims

IPC分类号： B32B5/16 ,  C11D3/20 ,  C11D3/22 ,  C11D3/37 ,  C11D3/38 ,  C11D3/386 ,  C11D17/04

摘要： Disclosed herein are water soluble compositions, such as films, including a mixture of a first water-soluble resin, an enzyme, and an enzyme stabilizer which comprises a functional substrate for the enzyme, methods of making such compositions, and methods of using such compositions, e.g. to make packets containing functional ingredients. The enzymes can include proteases and mixtures of proteases with other enzymes, and the compositions provide good retention of enzyme function following film processing and storage.

公开(公告)号：US20180118906A1

公开(公告)日：2018-05-03

申请号：US15796516

申请日：2017-10-27

申请人： David M. Lee ,  Percy Bromby, II

发明人： David M. Lee ,  Percy Bromby, II

IPC分类号： C08J5/18 ,  C11D17/04 ,  A61K8/02 ,  A61Q5/02 ,  A61Q19/10

CPC分类号： C08J5/18 ,  A61K8/02 ,  A61K2800/87 ,  A61Q5/02 ,  A61Q19/10 ,  B65D65/46 ,  C08J2329/04 ,  C08J2403/02 ,  C08J2403/08 ,  C08J2403/18 ,  C11D17/042 ,  Y02W90/11

摘要： The disclosure provides a water-soluble film, including a mixture of a water-soluble polyvinyl alcohol, a plasticizer, and a starch, wherein (a) the starch includes a hydroxypropylated starch in an amount of about 5 phr to about 30 phr; (b) the starch includes a modified starch having a degree of modification greater than about 2%, in an amount of about 2.5 phr to about 30 phr; (c) the starch is an unmodified starch having an amylose content of about 20% to about 80%; or (d) the starch includes a hydroxypropylated starch having an amylose content of about 23% to about 95% and the polyvinyl alcohol includes unmodified polyvinyl alcohol or anionic modified polyvinyl alcohol with the proviso that the anionic modifier is not acrylate. The disclosure further provides a sealed article including a water-soluble film in the form of a pouch defining an interior pouch volume.

公开(公告)号：US09636806B1

公开(公告)日：2017-05-02

申请号：US14504294

申请日：2014-10-01

申请人： David M. Lee ,  Mike Zwiesler

发明人： David M. Lee ,  Mike Zwiesler

IPC分类号： B25B13/00 ,  B25B13/10 ,  B25B13/06 ,  B25B23/00 ,  B25B23/16

CPC分类号： B25B13/102 ,  B25B13/06 ,  B25B23/0035 ,  B25B23/16

摘要： A nut driver for driving nuts of various sizes includes an elongated housing with opposing driver and handle ends. The driver end is open and assumes a largest size. A rigid collar and plunger are fixed about the housing and positioned at any of a number of selectable radial positions, each of which is associated with a different nut size. A plurality of nested sockets are each slidably movable by the plunger between forward and rearward positions. Each socket has a foot adapted for contacting the plunger at one of the selectable radial positions. The elongated housing is preferably separated into two sections, including a handle and a two-sided socket mechanism that includes two opposing driver ends each having sockets of different sizes.

公开(公告)号：US08908688B2

公开(公告)日：2014-12-09

申请号：US13610363

申请日：2012-09-11

申请人： Chih-Cheh Chen ,  Michael T. Klinglesmith ,  David M. Lee ,  John Zulauf ,  Itay Franko ,  Peter J. Elardo ,  Mohan K. Nair ,  Chris Van Beek

发明人： Chih-Cheh Chen ,  Michael T. Klinglesmith ,  David M. Lee ,  John Zulauf ,  Itay Franko ,  Peter J. Elardo ,  Mohan K. Nair ,  Chris Van Beek

IPC分类号： H04L12/28 ,  H04J3/26 ,  H04L12/18 ,  H04L12/931

CPC分类号： H04L12/18 ,  H04L49/00

摘要： Devices and method with hardware configured to support phantom register programming. Where phantom register programming allows a device driver for an endpoint device to program multicast registers in the device without support of the operating system.

摘要翻译： 硬件配置支持幻像寄存器编程的设备和方法。 幻影寄存器编程允许端点设备的设备驱动程序在设备中对组播寄存器进行编程，而无需支持操作系统。

公开(公告)号：US08905236B2

公开(公告)日：2014-12-09

申请号：US13016621

申请日：2011-01-28

申请人： Frank W. Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Roxane Rosmaninho ,  Jichun Shi ,  Andrew P. Verrall

发明人： Frank W. Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Roxane Rosmaninho ,  Jichun Shi ,  Andrew P. Verrall

IPC分类号： B65D85/84 ,  C08J5/18 ,  C11D17/04 ,  C08L29/04 ,  B65D65/46

CPC分类号： C08L29/04 ,  B65D65/46 ,  C08J5/18 ,  C08J2329/04 ,  C08L2203/16 ,  C08L2205/025 ,  C11D17/042 ,  C11D17/045 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/1345

摘要： Disclosed is a pouch having at least one sealed compartment containing a first composition. At least one wall of the at least one sealed compartment is made from a water-soluble film having any suitable thickness. The water-soluble film comprises PVOH polymer such that when the film has a thickness of about 76 microns the film is characterized by a Dissolution Index of about 620 to about 920, or of about 665 to about 920, or about 710 to about 920; and a Stress Index of about 145 to about 626, or about 155 to about 480, or about 165 to about 325.

摘要翻译： 公开了一种具有至少一个包含第一组合物的密封隔室的袋。 至少一个密封隔室的至少一个壁由具有任何合适厚度的水溶性薄膜制成。 该水溶性膜包含PVOH聚合物，使得当该膜的厚度为约76微米时，该膜的特征在于溶解指数为约620至约920，或约665至约920，或约710至约920; 和约145至约626，或约155至约480，或约165至约325的应力指数。

公开(公告)号：US20140129747A1

公开(公告)日：2014-05-08

申请号：US14145376

申请日：2013-12-31

申请人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

发明人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

IPC分类号： G06F13/42

CPC分类号： H04L47/10 ,  G06F5/06 ,  G06F13/124 ,  G06F13/385 ,  G06F13/4059 ,  G06F13/42 ,  G06F13/4221 ,  G06F13/4252 ,  G06F13/4265 ,  G06F13/4269 ,  G06F13/4282 ,  H04L47/30

摘要： A storage device is provided to maintain a count of flow control credits to be granted to a device in association with transactions over a channel to be implemented on a data link and control logic is provided to communicate, to the device, an indication of an amount of flow control credits for the device in association with a reset of the data link.

摘要翻译： 提供一种存储装置，用于维持要通过要在数据链路上实现的信道上的事务相关联地授予设备的流量控制信用的计数，并且提供控制逻辑以向该设备传送数量的指示 与数据链路的重置相关联的设备的流量控制信用。

公开(公告)号：US08566473B2

公开(公告)日：2013-10-22

申请号：US12395497

申请日：2009-02-27

申请人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

发明人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

IPC分类号： G06F15/16

CPC分类号： H04L47/10 ,  G06F5/06 ,  G06F13/124 ,  G06F13/385 ,  G06F13/4059 ,  G06F13/42 ,  G06F13/4221 ,  G06F13/4252 ,  G06F13/4265 ,  G06F13/4269 ,  G06F13/4282 ,  H04L47/30

摘要： An enhanced general input/output communication architecture, protocol and related methods are presented. In one embodiment, a method for an enhanced general input/output communication architecture includes initializing a flow control mechanism within an general input/output (GIO) interface associated with a virtual channel upon initialization of the virtual channel, and tracking receive buffer availability in a remote GIO interface coupled with the GIO interface by the virtual channel by monitoring an indication associated with an amount of content transmitted from the GIO interface to the remote GIO interface.

摘要翻译： 提出了一种增强的通用输入/输出通信架构，协议和相关方法。 在一个实施例中，用于增强的一般输入/输出通信架构的方法包括：初始化虚拟通道初始化时初始化与虚拟通道相关联的通用输入/输出（GIO）接口内的流控制机制，以及在虚拟通道初始化时跟踪接收缓冲区可用性 通过监视与从GIO接口发送到远程GIO接口的内容量相关联的指示，通过虚拟通道与远程GIO接口耦合到GIO接口。

公开(公告)号：US08276756B2

公开(公告)日：2012-10-02

申请号：US13017382

申请日：2011-01-31

申请人： Frank William Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M Lee ,  Jichun Shi ,  Andrew P. Verrall ,  Roxane Rosmaninho

发明人： Frank William Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M Lee ,  Jichun Shi ,  Andrew P. Verrall ,  Roxane Rosmaninho

IPC分类号： B65D85/84

CPC分类号： C08L29/04 ,  B65D65/46 ,  C08J5/18 ,  C08J2329/04 ,  C08L2203/16 ,  C08L2205/025 ,  C11D17/042 ,  C11D17/045 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/1345

摘要： Disclosed is a pouch having at least one sealed compartment containing a first composition. At least one wall of the at least one sealed compartment is made from a water-soluble film having any suitable thickness. The water-soluble film comprises PVOH polymer such that when the film has a thickness of about 76 microns the film is characterized by a Dissolution Index of about 620 to about 920, or of about 665 to about 920, or about 710 to about 920; and a Stress Index of about 145 to about 626, or about 155 to about 480, or about 165 to about 325.

摘要翻译： 公开了一种具有至少一个包含第一组合物的密封隔室的袋。 至少一个密封隔室的至少一个壁由具有任何合适厚度的水溶性薄膜制成。 该水溶性膜包含PVOH聚合物，使得当该膜的厚度为约76微米时，该膜的特征在于溶解指数为约620至约920，或约665至约920，或约710至约920; 和约145至约626，或约155至约480，或约165至约325的应力指数。

公开(公告)号：US08224579B2

公开(公告)日：2012-07-17

申请号：US11638254

申请日：2006-12-13

申请人： Reuben Gobezie ,  David M. Lee

发明人： Reuben Gobezie ,  David M. Lee

IPC分类号： G01N33/48 ,  C12Q1/68 ,  G06F7/60 ,  G06G7/58

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/105

摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, OA subtype, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.

摘要翻译： 本发明涉及与骨关节炎（OA）临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供其表达与OA，OA亚型和/或OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。

公开(公告)号：US08073530B2

公开(公告)日：2011-12-06

申请号：US12749312

申请日：2010-03-29

申请人： Matthew S. Solar ,  Thomas L. Bridges ,  David M. Lee ,  Mark S. Freas

发明人： Matthew S. Solar ,  Thomas L. Bridges ,  David M. Lee ,  Mark S. Freas

IPC分类号： A61B5/05

CPC分类号： A61B34/20 ,  A61B34/10 ,  A61B90/39 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/0801 ,  A61B2090/363 ,  A61B2090/3916 ,  A61B2090/3937 ,  A61B2090/3954 ,  A61B2090/397 ,  A61B2090/3983 ,  A61B2090/3987 ,  A61B2090/3995

摘要： This document discusses, among other things, fiducial marker devices, tools, and methods. One example illustrates a combined imagable fiducial locator and divot for receiving a positioning wand of an image-guided surgical (IGS) workstation. A further example is reflective such that it is locatable by a remote detector of an optical positioning system. A generally cylindrical (e.g., faceted cylindrical) columnar locator permits easy application of reflective tape. Other examples discusses a unitary fiducial marker with multiple divots and a swiveling and/or tilted fiducial marker divot, each of which allows manipulation of a positioning wand into a remote camera's field of view. Another example includes at least one reflector that can be aimed. A further example discusses an imagable fiducial marker carrier that is attachable to a single location on a patient's skull to reduce trauma. A keying arrangement fixedly defines the orientation of the carrier, allowing detachment and reattachment in the same orientation.

摘要翻译： 本文件除其他外，讨论了基准标记设备，工具和方法。 一个示例示出了用于接收图像引导手术（IGS）工作站的定位棒的组合的可成像的基准定位器和纹章。 另一示例是反射性的，使得其可由光学定位系统的远程检测器定位。 通常为圆柱形（例如，小圆柱形）柱状定位器允许容易地使用反射带。 其他例子讨论了具有多个纹理的单一基准标记和一个旋转和/或倾斜的基准标记物，每个都可以将定位棒操纵到远程摄像机的视场。 另一示例包括可以瞄准的至少一个反射器。 另一个例子讨论了一个可以成像的基准标记载体，其可以附着到患者​​头骨上的单个位置以减少创伤。 键合装置固定地限定载体的取向，允许在相同取向上的分离和再附着。