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公开(公告)号：US07108969B1
公开(公告)日：2006-09-19
申请号：US09950016
申请日：2001-09-10
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Methods of monitoring the expression of genes in malignant oral cells is disclosed. Gene expression profiles are used to identify markers associated with malignant oral cells and to diagnose oral cancer.
摘要翻译： 公开了监测恶性口腔细胞中基因表达的方法。 基因表达谱用于鉴定与恶性口腔细胞相关的标记物并诊断口腔癌症。
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公开(公告)号：US10072297B2
公开(公告)日：2018-09-11
申请号：US10589788
申请日：2005-02-17
申请人： David T. W. Wong , Maie A. R. St. John , Yang Li
发明人： David T. W. Wong , Maie A. R. St. John , Yang Li
IPC分类号： C12Q1/68 , C12Q1/6886
摘要： A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.
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公开(公告)号：US08728744B2
公开(公告)日：2014-05-20
申请号：US12739703
申请日：2008-10-27
申请人： Shen Hu , David T. W. Wong
发明人： Shen Hu , David T. W. Wong
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , G01N33/57407 , G01N33/6893 , G01N2800/18
摘要： The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a prognosis for oral cancer and periodontal disease. The present invention additionally provides novel methods of distinguishing between oral cancer and periodontal disease. Finally, kits are provided that find use in the practice of the methods of the invention.
摘要翻译： 本发明涉及新型口腔癌和牙周病生物标志物的鉴定。 此外，本发明提供了诊断和提供口腔癌和牙周病预后的新方法。 本发明另外提供了区分口腔癌和牙周病的新方法。 最后，提供在实践本发明的方法中使用的试剂盒。
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4.发明申请HIGH SPECIFICITY AND HIGH SENSITIVITY DETECTION BASED ON STERIC HINDRANCE & ENZYME-RELATED SIGNAL AMPLIFICATION 审中-公开基于超声和酶相关信号放大的高特异度和高灵敏度检测公开(公告)号：US20130115594A1
公开(公告)日：2013-05-09
申请号：US13462709
申请日：2012-05-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/682 , C12Q1/6825 , C12Q2565/501 , C12Q2565/107 , C12Q2563/131 , C12Q2525/301 , C12Q2565/1025
摘要： The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of a target nucleic acid in a sample. Also disclosed is a detection method using this probe.
摘要翻译： 本发明涉及能够对样品中的靶核酸进行高灵敏度和高特异性检测的分子探针。 还公开了使用该探针的检测方法。
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公开(公告)号：US08257917B2
公开(公告)日：2012-09-04
申请号：US12475347
申请日：2009-05-29
申请人： David T. W. Wong , Shen Hu , Jianghua Wang
发明人： David T. W. Wong , Shen Hu , Jianghua Wang
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/101
摘要： The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of primary Sjögren's Syndrome. The present invention therefore provides methods of diagnosing and providing a prognosis for Sjögren's Syndrome, by examining relevant proteins (including certain autoantigens and autoantibodies) and RNA in a patient's saliva.
摘要翻译： 本发明首次提供可用于检测原发性Siegren综合征的唾液蛋白和RNA因子的鉴定。 因此，本发明提供了通过检查患者唾液中的相关蛋白质（包括某些自身抗原和自身抗体）和RNA来为Sjögren综合征诊断并提供预后的方法。
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公开(公告)号：US06264948B1
公开(公告)日：2001-07-24
申请号：US09207445
申请日：1998-12-08
申请人： David T. W. Wong , Peter F. Weller
发明人： David T. W. Wong , Peter F. Weller
IPC分类号： A61K39395
CPC分类号： C07K16/244 , A61K38/00
摘要： A method of suppressing tumor cell growth, comprising administering to a mammal in need thereof an amount of an inhibitor of eosinophilia sufficient to result in suppression of tumor cell growth is disclosed.
摘要翻译： 一种抑制肿瘤细胞生长的方法，包括向有需要的哺乳动物施用一定量的足以导致抑制肿瘤细胞生长的嗜酸性粒细胞增多抑制剂。
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公开(公告)号：US6071741A
公开(公告)日：2000-06-06
申请号：US728839
申请日：1996-10-10
申请人： David T. W. Wong , Randy Todd
发明人： David T. W. Wong , Randy Todd
CPC分类号： C07K14/4703
摘要： Disclosed is an isolated tumor suppressor protein inducible by tumor necrosis factor. Also disclosed are isolated cDNA molecules encoding the doc-1, a tumor suppressor protein, cells transformed with this cDNA, antibodies specific for and reactive with the doc-1 protein, and methods of using these proteins, cDNAs, and antibodies.
摘要翻译： 公开了一种由肿瘤坏死因子诱导的分离的肿瘤抑制蛋白。 还公开了编码doc-1，肿瘤抑制蛋白，用该cDNA转化的细胞，对doc-1蛋白具有特异性并且与doc-1蛋白有反应性的抗体的分离的cDNA分子，以及使用这些蛋白质，cDNAs和抗体的方法。
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8.发明授权Biomarkers for oral tongue cancer metastasis and extracapsular spread (ECS) 有权口腔舌癌转移和囊外扩散的生物标记物（ECS）公开(公告)号：US07588895B2
公开(公告)日：2009-09-15
申请号：US11622061
申请日：2007-01-11
申请人： David T. W. Wong , Xiaofeng Zhou
发明人： David T. W. Wong , Xiaofeng Zhou
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57407
摘要： The present invention provides for the first time molecular diagnostic and prognostic markers for tongue cancer metastasis and extracapsular spread that are independent of histopathological evaluation.
摘要翻译： 本发明提供了独立于组织病理学评估的舌癌转移和囊外扩散的第一次分子诊断和预后标志物。
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公开(公告)号：US6001357A
公开(公告)日：1999-12-14
申请号：US143467
申请日：1998-08-27
申请人： David T. W. Wong , Peter F. Weller
发明人： David T. W. Wong , Peter F. Weller
CPC分类号： C07K16/244 , A61K38/193 , A61K2039/505
摘要： The invention provides a method of enhancing wound healing, comprising administering an inhibitor of eosinophil influx into a wound site sufficient to result in healing of the wound.
摘要翻译： 本发明提供了一种增强伤口愈合的方法，包括将嗜酸性粒细胞浸润的抑制剂投入足以导致伤口愈合的伤口部位。
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