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9 条记录 (耗时 0.033 秒)

    Salivary mRNA profiling, biomarkers and related methods
    1.
    发明授权
    Salivary mRNA profiling, biomarkers and related methods 有权

    公开(公告)号：US10072297B2

    公开(公告)日：2018-09-11

    申请号：US10589788

    申请日：2005-02-17

    申请人： David T. W. Wong ,  Maie A. R. St. John ,  Yang Li

    发明人： David T. W. Wong ,  Maie A. R. St. John ,  Yang Li

    IPC分类号： C12Q1/68 ,  C12Q1/6886

    摘要： A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.

    Doc tumor suppressor protein and gene
    2.
    发明授权
    Doc tumor suppressor protein and gene 失效
    Doc肿瘤抑制蛋白和基因

    公开(公告)号：US6071741A

    公开(公告)日：2000-06-06

    申请号：US728839

    申请日：1996-10-10

    申请人： David T. W. Wong ,  Randy Todd

    发明人： David T. W. Wong ,  Randy Todd

    IPC分类号： C07K14/47 ,  C12N15/00 ,  A61K38/00 ,  C07H21/04

    CPC分类号： C07K14/4703

    摘要： Disclosed is an isolated tumor suppressor protein inducible by tumor necrosis factor. Also disclosed are isolated cDNA molecules encoding the doc-1, a tumor suppressor protein, cells transformed with this cDNA, antibodies specific for and reactive with the doc-1 protein, and methods of using these proteins, cDNAs, and antibodies.

    摘要翻译： 公开了一种由肿瘤坏死因子诱导的分离的肿瘤抑制蛋白。 还公开了编码doc-1，肿瘤抑制蛋白，用该cDNA转化的细胞，对doc-1蛋白具有特异性并且与doc-1蛋白有反应性的抗体的分离的cDNA分子，以及使用这些蛋白质，cDNAs和抗体的方法。

    Salivary protein biomarkers for human oral cancer
    6.
    发明授权
    Salivary protein biomarkers for human oral cancer 有权
    唾液蛋白生物标志物用于人类口腔癌

    公开(公告)号：US08728744B2

    公开(公告)日：2014-05-20

    申请号：US12739703

    申请日：2008-10-27

    申请人： Shen Hu ,  David T. W. Wong

    发明人： Shen Hu ,  David T. W. Wong

    IPC分类号： G01N33/574

    CPC分类号： C12Q1/6886 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2800/18

    摘要： The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a prognosis for oral cancer and periodontal disease. The present invention additionally provides novel methods of distinguishing between oral cancer and periodontal disease. Finally, kits are provided that find use in the practice of the methods of the invention.

    摘要翻译： 本发明涉及新型口腔癌和牙周病生物标志物的鉴定。 此外，本发明提供了诊断和提供口腔癌和牙周病预后的新方法。 本发明另外提供了区分口腔癌和牙周病的新方法。 最后，提供在实践本发明的方法中使用的试剂盒。

    Salivary biomarkers for Sjögren's syndrome
    8.
    发明授权
    Salivary biomarkers for Sjögren's syndrome 有权
    Sjögren综合征的唾液生物标志物

    公开(公告)号：US08257917B2

    公开(公告)日：2012-09-04

    申请号：US12475347

    申请日：2009-05-29

    申请人： David T. W. Wong ,  Shen Hu ,  Jianghua Wang

    发明人： David T. W. Wong ,  Shen Hu ,  Jianghua Wang

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/101

    摘要： The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of primary Sjögren's Syndrome. The present invention therefore provides methods of diagnosing and providing a prognosis for Sjögren's Syndrome, by examining relevant proteins (including certain autoantigens and autoantibodies) and RNA in a patient's saliva.

    摘要翻译： 本发明首次提供可用于检测原发性Siegren综合征的唾液蛋白和RNA因子的鉴定。 因此，本发明提供了通过检查患者唾液中的相关蛋白质（包括某些自身抗原和自身抗体）和RNA来为Sjögren综合征诊断并提供预后的方法。

    Methods and compositions for inhibiting tumor cell growth
    9.
    发明授权
    Methods and compositions for inhibiting tumor cell growth 失效
    抑制肿瘤细胞生长的方法和组合物

    公开(公告)号：US06264948B1

    公开(公告)日：2001-07-24

    申请号：US09207445

    申请日：1998-12-08

    申请人： David T. W. Wong ,  Peter F. Weller

    发明人： David T. W. Wong ,  Peter F. Weller

    IPC分类号： A61K39395

    CPC分类号： C07K16/244 ,  A61K38/00

    摘要： A method of suppressing tumor cell growth, comprising administering to a mammal in need thereof an amount of an inhibitor of eosinophilia sufficient to result in suppression of tumor cell growth is disclosed.

    摘要翻译： 一种抑制肿瘤细胞生长的方法，包括向有需要的哺乳动物施用一定量的足以导致抑制肿瘤细胞生长的嗜酸性粒细胞增多抑制剂。