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    Characterization of a human hematopoietic progenitor cell antigen
    4.
    发明授权
    Characterization of a human hematopoietic progenitor cell antigen 失效
    人类造血祖细胞抗原的表征

    公开(公告)号：US5843633A

    公开(公告)日：1998-12-01

    申请号：US639891

    申请日：1996-04-26

    申请人： Amy Yin ,  Sheri Miraglia ,  David W. Buck

    发明人： Amy Yin ,  Sheri Miraglia ,  David W. Buck

    IPC分类号： C12N15/02 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C12N5/10 ,  C12N5/20 ,  C12P21/08 ,  G01N33/53 ,  G01N33/577

    CPC分类号： C07K16/28 ,  C07K14/705

    摘要： An hematopoietic progenitor cell antigen, and antibodies that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult peripheral blood. The subset of cells recognized by AC133 is CD34.sup.bright, and contains substantially all of the CFU-GM activity present in the CD34.sup.+ population. This highly specific distribution of AC133 makes it exceptionally useful as a reagent for isolating and characterizing human hematopoietic progenitor and stem cells. Cells selected for expression of AC133 antigen may be further purified by selection for other hematopoietic stem cell and progenitor cell markers.

    摘要翻译： 提供造血祖细胞抗原和特异性结合抗原的抗体。 抗原的表达是高度组织特异性的。 仅在衍生自人骨髓，胎儿骨髓和肝脏，脐带血和成人外周血的造血祖细胞的子集上检测到。 AC133识别的细胞亚群是CD34bright，并且包含存在于CD34 +群体中的基本上所有的CFU-GM活性。 这种高度特异性的AC133分布使其特别有用作分离和表征人类造血祖细胞和干细胞的试剂。 选择用于表达AC133抗原的细胞可以通过选择其它造血干细胞和祖细胞标记进一步纯化。

    L60: a novel monoclonal antibody
    5.
    发明授权
    L60: a novel monoclonal antibody 失效
    L60：一种新型单克隆抗体

    公开(公告)号：US4945056A

    公开(公告)日：1990-07-31

    申请号：US139491

    申请日：1987-12-30

    申请人： David W. Buck ,  Jane M. Bindl

    发明人： David W. Buck ,  Jane M. Bindl

    IPC分类号： C07K16/28 ,  C07K16/30

    CPC分类号： C07K16/30 ,  C07K16/28 ,  Y10S435/948

    摘要： L60 is a novel monoclonal antibody that will react with Leu 22. It is equally reactive in formalin, ZnSO.sub.4 or Bouin's fixed, paraffin-embedded tissues as well as in frozen tissues.

    摘要翻译： L60是一种能与Leu 22反应的新型单克隆抗体。它在福尔马林，ZnSO4或Bouin固定的石蜡包埋组织以及冷冻组织中同样具有反应性。

    Probe for monitoring radio frequency voltage and current
    7.
    发明授权
    Probe for monitoring radio frequency voltage and current 失效
    用于监测射频电压和电流的探头

    公开(公告)号：US06239587B1

    公开(公告)日：2001-05-29

    申请号：US09001815

    申请日：1997-12-31

    申请人： David W. Buck

    发明人： David W. Buck

    IPC分类号： G01R2726

    CPC分类号： G01R1/24 ,  G01R1/06772 ,  G01R27/16

    摘要： A probe (10) has a main body (12), an input side (14) and an output side (16). The main body (12) has a cavity (17) to receive an insulator (18). The insulator (18) has a current slit (22) and a voltage slit (24) aligned with a first aperture (30a) and a second aperture (30b). An inner conductor extends through the insulator (18) from the input side (14) to the output side (42) of the main body (12). A current sensor (40) inserts into the first aperture (30a) and the current slit (22). A voltage sensor (50) inserts into the second aperture (30b) and the voltage slit (24). A radio frequency signal on a transmission line having a same impedance as the probe (10) enters the inner conductor (20) at the input side (14), induces a current onto the current sensor (40) and a voltage onto the voltage sensor (50). The induced current and voltage can be measured to monitor the characteristics of the transmission line.

    摘要翻译： 探针（10）具有主体（12），输入侧（14）和输出侧（16）。 主体（12）具有用于容纳绝缘体（18）的空腔（17）。 绝缘体（18）具有与第一孔（30a）和第二孔（30b）对准的电流狭缝（22）和电压狭缝（24）。 内导体从输入侧（14）延伸穿过绝缘体（18）到主体（12）的输出侧（42）。 电流传感器（40）插入到第一孔（30a）和当前狭缝（22）中。 电压传感器（50）插入第二孔（30b）和电压狭缝（24）中。 在具有与探头（10）相同阻抗的传输线上的射频信号在输入侧（14）进入内部导体（20），在电流传感器（40）上感应出电流，并将电压传递到电压传感器 （50）。 可以测量感应电流和电压以监测传输线的特性。

    Composition comprising a cell expressing an AC133 cell surface antigen and an antibody or antigen-binding fragment
    8.
    发明授权
    Composition comprising a cell expressing an AC133 cell surface antigen and an antibody or antigen-binding fragment 失效
    包含表达AC133细胞表面抗原的细胞和抗体或抗原结合片段的组合物

    公开(公告)号：US08084033B2

    公开(公告)日：2011-12-27

    申请号：US12169336

    申请日：2008-07-08

    申请人： Amy H. Yin ,  Sheri Miraglia ,  Wayne G. Godfrey ,  David W. Buck

    发明人： Amy H. Yin ,  Sheri Miraglia ,  Wayne G. Godfrey ,  David W. Buck

    IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K17/00 ,  C12P21/08

    CPC分类号： C07K14/705 ,  C07K16/28 ,  G01N33/56966 ,  Y10S530/806 ,  Y10S530/838

    摘要： Compositions comprising a cell expressing an AC133 cell surface antigen and an antibody, or antigen binding fragment thereof, that specifically binds to the antigen are provided. Expression of the antigen is highly tissue specific. It is detected on a subset of hematopoietic progenitor and stem cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult peripheral blood. The subset of cells recognized by AC133 is CD34bright and contains substantially all of the CFU-GM activity present in the CD34+ population. This highly specific distribution of AC133 makes it exceptionally useful as a reagent for isolating and characterizing human hematopoietic progenitor and stem cells. Cells selected for expression of AC133 antigen can be further purified by selection for other hematopoietic stem cell and progenitor cell markers.

    摘要翻译： 提供了包含特异性结合抗原的表达AC133细胞表面抗原的细胞和抗体或其抗原结合片段的组合物。 抗原的表达是高度组织特异性的。 在源自人骨髓，胎儿骨髓和肝脏，脐带血和成人外周血的造血祖细胞和干细胞的子集上检测到。 由AC133识别的细胞亚群是CD34bright并且基本上包含存在于CD34 +群体中的所有CFU-GM活性。 这种高度特异性的AC133分布使其特别有用作分离和表征人类造血祖细胞和干细胞的试剂。 选择用于表达AC133抗原的细胞可以通过选择其他造血干细胞和祖细胞标记进一步纯化。

    Human Hematopoietic Stem And Progenitor Antigen And Methods For Its Use
    9.
    发明申请
    Human Hematopoietic Stem And Progenitor Antigen And Methods For Its Use 失效
    人造血干细胞和祖细胞抗原及其使用方法

    公开(公告)号：US20090093052A1

    公开(公告)日：2009-04-09

    申请号：US12169336

    申请日：2008-07-08

    申请人： Amy H. Yin ,  Sheri Miraglia ,  David W. Buck

    发明人： Amy H. Yin ,  Sheri Miraglia ,  David W. Buck

    IPC分类号： C12N5/06 ,  C12N5/00

    CPC分类号： C07K14/705 ,  C07K16/28 ,  G01N33/56966 ,  Y10S530/806 ,  Y10S530/838

    摘要： A hematopoietic progenitor cell antigen and reagents, notably antibodies, that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult peripheral blood. The subset of cells recognized by AC133 is CD34bright and contains substantially all of the CFU-GM activity present in the CD34+ population. This highly specific distribution of AC133 makes it exceptionally useful as a reagent for isolating and characterizing human hematopoietic progenitor and stem cells. Cells selected for expression of AC133 antigen can be further purified by selection for other hematopoietic stem cell and progenitor cell markers.

    摘要翻译： 提供了特异性结合抗原的造血祖细胞抗原和试剂，特别是抗体。 抗原的表达是高度组织特异性的。 仅在衍生自人骨髓，胎儿骨髓和肝脏，脐带血和成人外周血的造血祖细胞的子集上检测到。 由AC133识别的细胞亚群是CD34bright并且基本上包含存在于CD34 +群体中的所有CFU-GM活性。 这种高度特异性的AC133分布使其特别有用作分离和表征人类造血祖细胞和干细胞的试剂。 选择用于表达AC133抗原的细胞可以通过选择其他造血干细胞和祖细胞标记进一步纯化。