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1.发明申请METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY 有权使用肠杆菌属家禽生产L-氨基酸的方法公开(公告)号：US20110177566A1
公开(公告)日：2011-07-21
申请号：US13004188
申请日：2011-01-11
申请人： Ekaterina Alekseevna Savrasova , Natalia Viktorovna Stoynova , Gen Nonaka , Shunsuke Yamazaki , Kazuhiro Takumi
发明人： Ekaterina Alekseevna Savrasova , Natalia Viktorovna Stoynova , Gen Nonaka , Shunsuke Yamazaki , Kazuhiro Takumi
IPC分类号： C12P13/24 , C12P13/04 , C12P13/22 , C12P13/08 , C12P13/12 , C12P13/06 , C12P13/20 , C12P13/14 , C12P13/10
摘要： A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine.
摘要翻译： 使用肠杆菌科的细菌描述L-氨基酸的制备方法，其中该细菌含有能够赋予L-半胱氨酸对生长抑制的抗性的蛋白质。
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2.发明授权L-threonine producing bacterium belonging to the genus Escherichia and method for producing L-threonine 有权属于埃希氏杆菌属的L-苏氨酸生产菌和L-苏氨酸生产方法公开(公告)号：US07186531B2
公开(公告)日：2007-03-06
申请号：US11002072
申请日：2004-12-03
申请人： Valery Zavenovich Akhverdian , Ekaterina Alekseevna Savrasova , Alla Markovna Kaplan , Andrey Olegovich Lobanov , Yuri Ivanovich Kozlov
发明人： Valery Zavenovich Akhverdian , Ekaterina Alekseevna Savrasova , Alla Markovna Kaplan , Andrey Olegovich Lobanov , Yuri Ivanovich Kozlov
CPC分类号： C12N9/0008 , C12P13/08
摘要： There is disclosed a method for producing L-threonine using bacterium belonging to the genus Escherichia wherein the bacterium has been modified to enhance an activity of aspartate-β-semialdehyde dehydrogenase.
摘要翻译： 公开了使用属于埃希氏杆菌属的细菌生产L-苏氨酸的方法，其中细菌已被修饰以增强天冬氨酸-β-半醛脱氢酶的活性。
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3.发明授权Method for producing L-amino acids using bacteria of the enterobacteriaceae family 有权使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US08785161B2
公开(公告)日：2014-07-22
申请号：US13466266
申请日：2012-05-08
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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4.发明授权Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family 有权使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US08460903B2
公开(公告)日：2013-06-11
申请号：US13004188
申请日：2011-01-11
申请人： Ekaterina Alekseevna Savrasova , Natalia Viktorovna Stoynova , Gen Nonaka , Shunsuke Yamazaki , Kazuhiro Takumi
发明人： Ekaterina Alekseevna Savrasova , Natalia Viktorovna Stoynova , Gen Nonaka , Shunsuke Yamazaki , Kazuhiro Takumi
摘要： A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine.
摘要翻译： 使用肠杆菌科的细菌描述L-氨基酸的制备方法，其中该细菌含有能够赋予L-半胱氨酸对生长抑制的抗性的蛋白质。
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5.发明申请METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY 有权使用肠杆菌属细菌生产L-氨基酸的方法公开(公告)号：US20120219996A1
公开(公告)日：2012-08-30
申请号：US13466266
申请日：2012-05-08
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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6.发明授权Method for producing L-amino acids using bacteria of the Enterobacteriaceae family 有权使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US07915018B2
公开(公告)日：2011-03-29
申请号：US11247138
申请日：2005-10-12
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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公开(公告)号：US08728774B2
公开(公告)日：2014-05-20
申请号：US13032057
申请日：2011-02-22
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
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8.发明申请METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY 有权使用肠杆菌属细菌生产L-氨基酸的方法公开(公告)号：US20110143403A1
公开(公告)日：2011-06-16
申请号：US13032057
申请日：2011-02-22
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译： 公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌 已被修饰以增强D-木糖通透酶的活性。
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9.发明授权Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine using Escherichia bacteria 有权使用大肠杆菌生产α-L-天冬氨酰-L-苯丙氨酸的低级烷基酯的方法公开(公告)号：US07531332B2
公开(公告)日：2009-05-12
申请号：US11761465
申请日：2007-06-12
申请人： Vitaliy Arkadyevich Livshits , Maria Viacheslavovna Vitushkina , Mikhail Markovich Gusyatiner , Mikhail Kharisovich Ziyatdinov , Valery Zavenovich Akhverdian , Ekaterina Alekseevna Savrasova , Vera Georgievna Doroshenko , Sergey Vladimirovich Mashko
发明人： Vitaliy Arkadyevich Livshits , Maria Viacheslavovna Vitushkina , Mikhail Markovich Gusyatiner , Mikhail Kharisovich Ziyatdinov , Valery Zavenovich Akhverdian , Ekaterina Alekseevna Savrasova , Vera Georgievna Doroshenko , Sergey Vladimirovich Mashko
CPC分类号： C07K14/245 , C07K5/0613 , C12P13/04 , C12P13/08 , C12P13/222
摘要： A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing the activity of the protein encoded by the yedA gene. A further method is provided for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine by producing L-phenylalanine by cultivating an Escherichia coli bacterium in a medium, wherein said bacterium has the ability to produce L-phenylalanine, and synthesizing the lower alkyl ester of α-L-aspartyl-L-phenylalanine from aspartic acid, or a derivative thereof, and the produced L-phenylalanine.
摘要翻译： 使用埃希氏菌属细菌提供L-苯丙氨酸和L-苏氨酸生产L-氨基酸的方法，其中所述细菌的L-氨基酸生产力通过提高由yedA编码的蛋白质的活性来增强 基因。 提供了通过在培养基中培养大肠杆菌细菌产生L-苯丙氨酸来生产α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯的另一种方法，其中所述细菌具有产生L-苯丙氨酸的能力，并合成 来自天冬氨酸的α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯或其衍生物和所产生的L-苯丙氨酸。
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公开(公告)号：US20080153138A1
公开(公告)日：2008-06-26
申请号：US11761465
申请日：2007-06-12
申请人： Vitaliy Arkadyevich Livshits , Maria Viacheslavovna Vitushkina , Mikhail Markovich Gusyatiner , Mikhail Kharisovich Ziyatdinov , Valery Zavenovich Akhverdian , Ekaterina Alekseevna Savrasova , Vera Georgievna Doroshenko , Sergey Vladimirovich Mashko
发明人： Vitaliy Arkadyevich Livshits , Maria Viacheslavovna Vitushkina , Mikhail Markovich Gusyatiner , Mikhail Kharisovich Ziyatdinov , Valery Zavenovich Akhverdian , Ekaterina Alekseevna Savrasova , Vera Georgievna Doroshenko , Sergey Vladimirovich Mashko
CPC分类号： C07K14/245 , C07K5/0613 , C12P13/04 , C12P13/08 , C12P13/222
摘要： A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing the activity of the protein encoded by the yedA gene. A further method is provided for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine by producing L-phenylalanine by cultivating an Escherichia coli bacterium in a medium, wherein said bacterium has the ability to produce L-phenylalanine, and synthesizing the lower alkyl ester of α-L-aspartyl-L-phenylalanine from aspartic acid, or a derivative thereof, and the produced L-phenylalanine.
摘要翻译： 使用埃希氏菌属细菌提供L-苯丙氨酸和L-苏氨酸生产L-氨基酸的方法，其中所述细菌的L-氨基酸生产力通过提高由yedA编码的蛋白质的活性来增强 基因。 提供了通过在培养基中培养大肠杆菌细菌产生L-苯丙氨酸来生产α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯的另一种方法，其中所述细菌具有生产L-苯丙氨酸的能力，并合成 来自天冬氨酸的α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯或其衍生物和所产生的L-苯丙氨酸。
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