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1.Piperidine and Piperazine Phenyl Sulfonamides as Modulators of Ion Channels 有权
标题翻译: 哌啶和哌嗪苯磺酰胺作为离子通道的调节剂公开(公告)号:US20130035310A1
公开(公告)日:2013-02-07
申请号:US13633478
申请日:2012-10-02
申请人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A61K31/635 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/427 , A61K31/695 , A61P29/00 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/08 , A61P9/06 , A61P25/28 , A61P19/02 , A61P9/12 , A61P1/00 , A61K31/506
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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2.
公开(公告)号:US08236829B2
公开(公告)日:2012-08-07
申请号:US12938556
申请日:2010-11-03
申请人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
发明人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
IPC分类号: A61K31/426 , A61K31/4245 , A61K31/425 , C07D277/52 , C07D271/07 , C07D271/113 , C07D275/03
CPC分类号: C07D417/12 , C07D277/52
摘要: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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3.
公开(公告)号:US08357702B2
公开(公告)日:2013-01-22
申请号:US13537903
申请日:2012-06-29
申请人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
发明人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
IPC分类号: C07D417/12 , C07D215/36 , C07D215/38 , A61K31/4709
CPC分类号: C07D417/12 , C07D277/52
摘要: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号:US20120308606A1
公开(公告)日:2012-12-06
申请号:US13537903
申请日:2012-06-29
申请人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
发明人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
IPC分类号: A61K31/47 , A61K31/4709 , A61K31/426 , C07D417/12 , C07D277/52 , C07D215/04 , A61K31/427 , A61P25/00 , A61P29/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P1/00 , A61K47/00
CPC分类号: C07D417/12 , C07D277/52
摘要: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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5.Piperidine and piperazine phenyl sulphonamides as modulators of ion channels 有权
标题翻译: 哌啶和哌嗪苯磺酰胺作为离子通道的调节剂公开(公告)号:US08309587B2
公开(公告)日:2012-11-13
申请号:US13419936
申请日:2012-03-14
申请人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N43/78 , A61K31/425
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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公开(公告)号:US08324220B2
公开(公告)日:2012-12-04
申请号:US12877793
申请日:2010-09-08
申请人: Dean Mitchell Wilson , Esther Ann Martinborough , Timothy Donald Neubert , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Hilgraf
发明人: Dean Mitchell Wilson , Esther Ann Martinborough , Timothy Donald Neubert , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Hilgraf
IPC分类号: A61K31/506 , A61P19/02 , A61P25/06 , A61P29/00 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号: C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08211935B2
公开(公告)日:2012-07-03
申请号:US12971609
申请日:2010-12-17
申请人: Andreas P. Termin , Esther Ann Martinborough , Nicole Hilgraf , Charles J. Cohen , Corey Anderson
发明人: Andreas P. Termin , Esther Ann Martinborough , Nicole Hilgraf , Charles J. Cohen , Corey Anderson
IPC分类号: A61K31/496 , A61K31/55
CPC分类号: A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译: 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
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公开(公告)号:US20110178061A1
公开(公告)日:2011-07-21
申请号:US12971609
申请日:2010-12-17
申请人: Andreas P. Termin , Esther Ann Martinborough , Nicole Hilgraf , Charles J. Cohen , Corey Anderson
发明人: Andreas P. Termin , Esther Ann Martinborough , Nicole Hilgraf , Charles J. Cohen , Corey Anderson
IPC分类号: A61K31/55 , C12N5/00 , A61K31/4525 , A61K31/4545 , A61K31/453 , A61K31/454 , A61K31/5377 , A61K31/506 , A61K31/443 , A61K31/541 , A61K31/496 , A61P29/00 , A61P25/24 , A61P25/28 , A61P25/22 , A61P25/08 , A61P9/06
CPC分类号: A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译: 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
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9.
公开(公告)号:US20110112156A1
公开(公告)日:2011-05-12
申请号:US12938556
申请日:2010-11-03
申请人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
发明人: Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
IPC分类号: A61K31/426 , A61K31/427 , A61P29/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P9/06 , C12N5/071
CPC分类号: C07D417/12 , C07D277/52
摘要: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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