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1.Piperidine and piperazine phenyl sulphonamides as modulators of ion channels 有权
标题翻译: 哌啶和哌嗪苯磺酰胺作为离子通道的调节剂公开(公告)号:US08309587B2
公开(公告)日:2012-11-13
申请号:US13419936
申请日:2012-03-14
申请人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N43/78 , A61K31/425
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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2.Piperidine and Piperazine Phenyl Sulfonamides as Modulators of Ion Channels 有权
标题翻译: 哌啶和哌嗪苯磺酰胺作为离子通道的调节剂公开(公告)号:US20130035310A1
公开(公告)日:2013-02-07
申请号:US13633478
申请日:2012-10-02
申请人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A61K31/635 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/427 , A61K31/695 , A61P29/00 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/08 , A61P9/06 , A61P25/28 , A61P19/02 , A61P9/12 , A61P1/00 , A61K31/506
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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3.
公开(公告)号:US08163720B2
公开(公告)日:2012-04-24
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N51/00 , A61N31/655
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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公开(公告)号:US20110082117A1
公开(公告)日:2011-04-07
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A61K31/635 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P25/00 , A61P13/00 , A61P17/00
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20120178713A1
公开(公告)日:2012-07-12
申请号:US13419936
申请日:2012-03-14
申请人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A61K31/496 , C07D403/12 , A61K31/506 , C07D417/14 , A61K31/501 , A61K31/454 , C07D471/04 , A61K31/437 , A61K31/427 , C07F7/02 , A61K31/695 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61P13/02 , C07D417/12
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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公开(公告)号:US07799822B2
公开(公告)日:2010-09-21
申请号:US11643622
申请日:2006-12-21
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号: A01N43/36
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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公开(公告)号:US20080027067A1
公开(公告)日:2008-01-31
申请号:US11643622
申请日:2006-12-21
申请人: Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人: Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号: A61K31/495 , A61K31/426 , A61P29/00 , C07D401/00 , C07D403/00 , C07D277/02 , A61K31/445
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20170196862A2
公开(公告)日:2017-07-13
申请号:US14876525
申请日:2015-10-06
申请人: Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
发明人: Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号: A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC分类号: A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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9.MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权
标题翻译: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂公开(公告)号:US20120010257A1
公开(公告)日:2012-01-12
申请号:US13178677
申请日:2011-07-08
申请人: Sara Hadida-Ruah , Fredrick VanGoor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
发明人: Sara Hadida-Ruah , Fredrick VanGoor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC分类号: A61K31/427 , A61P25/16 , A61P35/00 , A61P25/28 , A61P27/02 , A61P13/12 , A61P11/00 , A61P3/10
CPC分类号: C07D417/14 , A61K31/427
摘要: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
摘要翻译: 本发明涉及囊性纤维化跨膜电导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。
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10.
公开(公告)号:US08586615B2
公开(公告)日:2013-11-19
申请号:US13178677
申请日:2011-07-08
申请人: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
发明人: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC分类号: A61K31/425 , C07D277/00
CPC分类号: C07D417/14 , A61K31/427
摘要: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
摘要翻译: 本发明涉及囊性纤维化跨膜电导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。
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