公开(公告)号：US5518722A

公开(公告)日：1996-05-21

申请号：US222371

申请日：1994-03-28

申请人： Erzebet Szaloki ,  Eva Szabo ,  Eva Hegedus ,  Erika Jacso ,  Iren Hangacsi ,  Kalman Kerek ,  Erzsebet Bereczki ,  Erzsebet Sas ,  Tunde Szabo ,  Erika Karancsi ,  Agnes Fabian ,  Zsolt gni ,  Gabriella Papp ,  Aniko Kovacs ,  Ilona Nagy ,  Tunde Jakab ,  Gabriella Demko ,  Erika Apagyi

发明人： Erzebet Szaloki ,  Eva Szabo ,  Eva Hegedus ,  Erika Jacso ,  Iren Hangacsi ,  Kalman Kerek ,  Erzsebet Bereczki ,  Erzsebet Sas ,  Tunde Szabo ,  Erika Karancsi ,  Agnes Fabian ,  Zsolt gni ,  Gabriella Papp ,  Aniko Kovacs ,  Ilona Nagy ,  Tunde Jakab ,  Gabriella Demko ,  Erika Apagyi

IPC分类号： A61K8/00 ,  A61K8/34 ,  A61K8/37 ,  A61K8/92 ,  A61K8/97 ,  A61K31/195 ,  A61K31/21 ,  A61K31/215 ,  A61K31/425 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K35/78 ,  A61K7/48

CPC分类号： A61K8/97 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/007

摘要： A skin regenerating composition which comprises as active ingredients a mixture of skin regeneratingly effective amounts each of an extract of the plants chickweed and pansy.

摘要翻译： 皮肤再生组合物，其包含作为活性成分的皮肤混合物，其再生有效量的植物锦蓟属和三色堇的提取物。

公开(公告)号：US5468492A

公开(公告)日：1995-11-21

申请号：US174202

申请日：1993-12-27

申请人： Erzsebet Szaloki ,  Ilona Kristof ,  Veronika Pal ,  Eva Szabo

发明人： Erzsebet Szaloki ,  Ilona Kristof ,  Veronika Pal ,  Eva Szabo

IPC分类号： A61K8/92 ,  A61K8/97 ,  A61K36/16 ,  A61K36/185 ,  A61K36/47 ,  A61K36/484 ,  A61K36/49 ,  A61K36/52 ,  A61K36/53 ,  A61K36/54 ,  A61K36/63 ,  A61K36/889 ,  A61K36/899 ,  A61Q7/00 ,  A61K35/78

CPC分类号： A61K36/54 ,  A61K36/16 ,  A61K36/185 ,  A61K36/47 ,  A61K36/484 ,  A61K36/49 ,  A61K36/52 ,  A61K36/53 ,  A61K36/63 ,  A61K36/889 ,  A61K36/899 ,  A61K8/922 ,  A61K8/97 ,  A61Q7/00

摘要： A topical cosmetic composition of an extract of a hair fallout reducing effective amount of Gingko biloba (maidenhair tree) leaves, and an extract of the root of Liquiritia officinalis (sweet-root), and one or more cosmetically acceptable solid or liquid carrier, and optionally one or more cosmetically acceptable supplementary ingredient.

摘要翻译： 提供减少有效量的银杏叶（maidenhair tree）叶的毛发粉碎提取物的局部化妆品组合物和甘草根（甜根）的提取物和一种或多种化妆品可接受的固体或液体载体，以及 任选地一种或多种美容上可接受的补充成分。

公开(公告)号：US20230000177A1

公开(公告)日：2023-01-05

申请号：US17857345

申请日：2022-07-05

申请人： Marilyn Weaver ,  Eva Szabo ,  Karen Barnette

发明人： Marilyn Weaver ,  Eva Szabo ,  Karen Barnette

IPC分类号： A41B13/10 ,  A47G11/00

摘要： The present invention relates to a disposable clothing cover that has an integrated napkin. The cover provides the functionality of a bib and a napkin and prohibits clothes from inadvertently becoming stained. The cover has cloth friendly adhesive lines which are used for removably attaching the cover to clothing of a wearer. A perforated curved portion positioned below the neck of a wearer of the cover is configured to be detached and functions like a napkin while the remaining part of the cover functions as a bib. The cover has a pair of adhesive tabs that can be used for securing a folded bottom edge of the cover enabling the creation of a pocket at the bottom of the cover to catch food items dropped during eating and drinking. The clothing cover can be packaged individually, formed in a roll, or stacked in a dispenser box.

公开(公告)号：US20120214236A1

公开(公告)日：2012-08-23

申请号：US13504745

申请日：2010-10-29

申请人： Mickie Bhatia ,  Eva Szabo ,  Shravanti Rampalli-Deshpande ,  Ruth Munoz Risueno ,  Kausalia Vijayaragavan

发明人： Mickie Bhatia ,  Eva Szabo ,  Shravanti Rampalli-Deshpande ,  Ruth Munoz Risueno ,  Kausalia Vijayaragavan

IPC分类号： C12N5/071

CPC分类号： C12N5/0618 ,  A61K35/12 ,  C12N5/0634 ,  C12N5/0696 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/13 ,  C12N2501/26 ,  C12N2501/41 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/605 ,  C12N2501/608 ,  C12N2506/1307 ,  C12N2510/00

摘要： The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor cells, without traversing the pluripotent state. Also provided is a method of isolating a subpopulation of fibroblasts with reprogramming potential comprising providing fibroblasts that express an Oct-4-reporter and isolating cells that are positive for the reporter. Further provided is a method of generating reprogrammed fibroblast-derived induced pluripotent stem cells. Also provided are uses and assays of the cells produced by the methods of the disclosure.

摘要翻译： 本公开提供了从成纤维细胞如真皮成纤维细胞产生祖细胞如造血细胞或神经祖细胞的方法，其包括提供用含有POU结构域的基因或蛋白质表达或治疗的成纤维细胞，并在下述条件下培养细胞： 允许生产祖细胞，而不穿过多能状态。 还提供了一种分离具有重编程电位的成纤维细胞亚群的方法，其包括提供表达Oct-4报道分子的成纤维细胞并分离对报告物呈阳性的细胞。 还提供了产生重编程的成纤维细胞衍生的多能干细胞的方法。 还提供了通过本公开的方法产生的细胞的用途和测定。

公开(公告)号：US09340772B2

公开(公告)日：2016-05-17

申请号：US13504745

申请日：2010-10-29

申请人： Mickie Bhatia ,  Eva Szabo ,  Shravanti Rampalli-Deshpande ,  Ruth Munoz Risueno

发明人： Mickie Bhatia ,  Eva Szabo ,  Shravanti Rampalli-Deshpande ,  Ruth Munoz Risueno

IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/079 ,  C12N5/078 ,  C12N5/074 ,  A61K35/12

CPC分类号： C12N5/0618 ,  A61K35/12 ,  C12N5/0634 ,  C12N5/0696 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/13 ,  C12N2501/26 ,  C12N2501/41 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/605 ,  C12N2501/608 ,  C12N2506/1307 ,  C12N2510/00

摘要： The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor cells, without traversing the pluripotent state. Also provided is a method of isolating a subpopulation of fibroblasts with reprogramming potential comprising providing fibroblasts that express an Oct-4-reporter and isolating cells that are positive for the reporter. Further provided is a method of generating reprogrammed fibroblast-derived induced pluripotent stem cells. Also provided are uses and assays of the cells produced by the methods of the disclosure.

摘要翻译： 本公开提供了从成纤维细胞例如真皮成纤维细胞产生祖细胞例如造血细胞或神经祖细胞的方法，其包括提供表达或用含有POU结构域的基因或蛋白质处理的成纤维细胞，并在条件下培养细胞， 允许生产祖细胞，而不穿过多能状态。 还提供了一种分离具有重编程潜力的成纤维细胞亚群的方法，其包括提供表达Oct-4报道分子的成纤维细胞并分离对报告物呈阳性的细胞。 还提供了产生重编程的成纤维细胞衍生的多能干细胞的方法。 还提供了通过本公开的方法产生的细胞的用途和测定。

公开(公告)号：US20120252697A1

公开(公告)日：2012-10-04

申请号：US13393475

申请日：2010-09-01

申请人： Mickie Bhatia ,  Tamra Werbowetski-Ogilvie ,  Eleftherios Sachlos ,  Daniela Fischer Russell ,  Sarah Laronde ,  JungBok Lee ,  Eva Szabo ,  Ruth M. Risueno

发明人： Mickie Bhatia ,  Tamra Werbowetski-Ogilvie ,  Eleftherios Sachlos ,  Daniela Fischer Russell ,  Sarah Laronde ,  JungBok Lee ,  Eva Szabo ,  Ruth M. Risueno

IPC分类号： C40B30/06 ,  G01N21/64 ,  C12N5/0735

CPC分类号： C12Q1/6897 ,  C12N5/0606 ,  C12N5/0695 ,  C12N2501/115

摘要： The present disclosure provides transformed human pluripotent stem cell (t-hPSC). t-hPSCs are not dependent on Oct4 for renewal and survival, however exhibit a sensitivity to reduced levels of the transcription factor Nanog. Also provided are methods of culturing cells for use in a cell-based screening assay comprising placing one or more transformed human pluripotent stem cells into a receptacle and culturing said stem cells in the receptacle to form a monolayer of stem cells without cell overlap. Methods of screening compounds using t-hPSCs are also described.

摘要翻译： 本公开提供了转化的人多能干细胞（t-hPSC）。 t-hPSC不依赖Oct4进行更新和生存，但对转录因子Nanog的降低水平表现出敏感性。 还提供培养用于基于细胞的筛选测定中的细胞的方法，包括将一个或多个转化的人多能干细胞置于容器中并在容器中培养所述干细胞以形成无细胞重叠的干细胞单层。 还描述了使用t-hPSC筛选化合物的方法。

公开(公告)号：US5391737A

公开(公告)日：1995-02-21

申请号：US156974

申请日：1993-11-24

申请人： Jozsef Reiter ,  Peter Trinka ,  Peter Tompe ,  Eva Szabo ,  Peter Slegel ,  Janos Brlik ,  Agnes Halbauer nee Nagy ,  Ilona Sztruhar ,  Magdolna Kenyeres nee Feher ,  Frigyes Gorgenyi ,  Margit Csorgo ,  Szvetlana Zsarnoczai nee Kurnyecova ,  Sarolta Benko nee Markus ,  Gabor Gigler ,  Dezso Danyi ,  Pal Fekete ,  Maria Kiraly nee Ignacz

发明人： Jozsef Reiter ,  Peter Trinka ,  Peter Tompe ,  Eva Szabo ,  Peter Slegel ,  Janos Brlik ,  Agnes Halbauer nee Nagy ,  Ilona Sztruhar ,  Magdolna Kenyeres nee Feher ,  Frigyes Gorgenyi ,  Margit Csorgo ,  Szvetlana Zsarnoczai nee Kurnyecova ,  Sarolta Benko nee Markus ,  Gabor Gigler ,  Dezso Danyi ,  Pal Fekete ,  Maria Kiraly nee Ignacz

IPC分类号： C07D239/84 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D239/84

摘要： This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium.The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds.The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

摘要翻译： 本发明涉及制备式（I）（阿那格雷）的6,7-二氯-1,5-二氢咪唑并[2,1-b] - 喹唑啉-2（3H）酮的新的和改进的方法 ），一种有价值的血小板抗凝聚化合物。 根据本发明的方法，式（I）化合物通过使新的具有式COOR1的2-氰基亚氨基喹唑啉衍生物在代表任选携带苯基取代基的低级烷基的后面的R1中经受热 在酸性介质中环化。 本发明还涉及用于生产阿那格雷的通式（III）的新的2-氰基亚氨基喹诺酮和所述化合物的制备。 本发明提供了一种制备阿那格雷的有利方法，其没有迄今已知方法的缺点，并且使得可能以工业规模生产式（I）化合物。