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公开(公告)号：US09572698B2
公开(公告)日：2017-02-21
申请号：US13980276
申请日：2012-01-17
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure (“ballstent”) and a flexible, elongated delivery device (“delivery catheter”) and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.
摘要翻译： 公开的是包括圆形，薄壁，可扩展金属结构（“球状液体”）和柔性细长输送装置（“输送导管”）的医疗装置以及用于用医疗装置治疗囊状血管动脉瘤的系统和方法 。 公开了可以压缩的位于动脉瘤内腔中的金，铂或银的球状体，并且膨胀以符合动脉瘤的形状。 球形体的外表面可以被配置为促进局部血栓形成并促进组织在球状体壁中和周围的生长，以便密封动脉瘤并将球状体固定在动脉瘤中的适当位置。 球状体的壁还可以被配置为释放药物或药理活性分子，例如促进血栓形成，细胞增殖，细胞外基质沉积和组织生长的分子。
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公开(公告)号：US09155827B2
公开(公告)日：2015-10-13
申请号：US13030054
申请日：2011-02-17
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1008 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M1/367 , A61M2205/0205 , A61M2205/3334 , A61M2206/10
摘要： A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.
摘要翻译： 提供了一种用于在足够的时间段内增加外周静脉血液和壁剪切应力（WSS）的速度并导致静脉总体直径和内腔直径持续增加的系统和方法。 该方法包括以期望的速率和搏动来抽血。 根据需要监测和调整泵送，以维持外周静脉期望的血液速度，WSS和搏动，以优化外周静脉扩张的速度和程度。
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3.发明申请公开(公告)号：US20140296767A1
公开(公告)日：2014-10-02
申请号：US14239251
申请日：2012-08-15
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
CPC分类号： A61M1/32 , A61B17/11 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1135 , A61M1/3655
摘要： A system and method for increasing the speed of blood and the wall shear stress in a peripheral artery or peripheral vein to a sufficient level and for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the artery or vein is provided. The method includes systems and methods to effect the movement of blood at the desired rate and in the desired direction. The movement of blood is monitored and adjusted, as necessary, to maintain the desired blood speed and wall shear stress in the peripheral artery or vein in order to optimize the rate and extent of persistent diameter increase of the peripheral artery or peripheral vein.
摘要翻译： 一种用于将外周动脉或外周静脉中的血液速度和壁剪切应力提高到足够的水平并足够的时间段以导致动脉的总直径和内腔直径持续增加的系统和方法，或 提供静脉。 该方法包括以期望的速率和期望的方向实现血液运动的系统和方法。 根据需要监测和调整血液的运动，以维持周围动脉或静脉中所需的血液速度和壁剪切应力，以优化外周动脉或外周静脉持续直径增加的速率和程度。
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公开(公告)号：US08568716B2
公开(公告)日：2013-10-29
申请号：US11454554
申请日：2006-06-16
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
IPC分类号： A61K38/46 , A61K38/48 , A61K38/55 , A61K35/39 , C12Q1/34 , C12Q1/37 , A61M25/06 , A61M29/02 , A61M31/00 , A61M25/085 , A61M25/10 , A61M29/00
CPC分类号： A61K38/486 , A61K38/4886 , A61K38/55
摘要： The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
摘要翻译： 本发明提供了治疗阻塞的生物导管的方法，其包括向导管施用可以降解阻塞组织的细胞外基质的试剂。 具体的方法包括将酶或多种酶的混合物递送到阻塞区域或区域，其中酶具有降解阻塞物内的细胞外基质成分的能力，从而恢复被输送流体通过导管的正常流动。 本发明还包括预防性扩张导管的一部分以最小化阻塞形成的风险。
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公开(公告)号：US20110201990A1
公开(公告)日：2011-08-18
申请号：US13030054
申请日：2011-02-17
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1008 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M1/367 , A61M2205/0205 , A61M2205/3334 , A61M2206/10
摘要： A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.
摘要翻译： 提供了一种用于在足够的时间段内增加外周静脉血液和壁剪切应力（WSS）的速度并导致静脉总体直径和内腔直径持续增加的系统和方法。 该方法包括以期望的速率和搏动来抽血。 根据需要监测和调整泵送，以维持外周静脉期望的血液速度，WSS和搏动，以优化外周静脉扩张的速度和程度。
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公开(公告)号：US20110008315A1
公开(公告)日：2011-01-13
申请号：US12746509
申请日：2008-12-04
CPC分类号： C12N9/6448 , A61K9/19 , A61K38/00 , A61K38/486 , C07K1/14 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C12N9/50 , C12N15/815 , C12P21/02 , C12Y304/21036 , C12Y304/21037
摘要： The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
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7.发明申请公开(公告)号：US20090162343A1
公开(公告)日：2009-06-25
申请号：US12327809
申请日：2008-12-03
CPC分类号： C12N9/6448 , A61K9/19 , A61K38/00 , A61K38/486 , C07K1/14 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C12N9/50 , C12N15/815 , C12P21/02 , C12Y304/21036 , C12Y304/21037
摘要： The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
摘要翻译： 本发明涉及生物活性重组弹性蛋白酶蛋白质的制造，纯化，配制和使用的方法。 描述了用于产生治疗上有用的弹性蛋白酶蛋白质的重组方法，以及包含所述弹性蛋白酶蛋白质的药物组合物。 还公开了新的重组弹性蛋白酶蛋白质和蛋白质制剂。 描述了使用含有本发明的弹性蛋白酶蛋白质的药物组合物治疗和预防生物管道疾病的方法。
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公开(公告)号：US11090176B2
公开(公告)日：2021-08-17
申请号：US13980278
申请日：2012-01-17
摘要： A medical device comprising a compressed, inflatable, detachable single-lobed metal balloon attached to a catheter and methods of use for occluding blood vessels or treating vascular aneurysms are disclosed. The balloon can be made with ductile metals such as gold, platinum, or silver so that the balloon will conform to the shape of the void space during inflation and so that the balloon can be subsequently shaped by the application of an external force. The balloon can be configured such that it can be detached from the catheter by physical means or by electrolysis. The surface of the balloon can be configured to promote the growth of tissue into the wall of the balloon and to release drugs or pharmacologically active molecules, so that vessel occlusion or the sealing of an aneurysm will be maintained over time.
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公开(公告)号：US11013516B2
公开(公告)日：2021-05-25
申请号：US14372967
申请日：2012-07-17
摘要： Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body (“ballstent” or “blockstent”) and a flexible, elongated delivery device (“delivery catheter”) and systems and methods of use for treating saccular vascular aneurysms and methods of use for occluding segments of blood vessels and other biological conduits. Expandable bodies comprising gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm or blood vessel, and expanded to conform to the shape of the aneurysm or segment of blood vessel or biological conduit are disclosed.
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公开(公告)号：US09662431B2
公开(公告)日：2017-05-30
申请号：US14421767
申请日：2013-08-15
申请人： FLOW FORWARD MEDICAL, INC. , F. Nicholas Franano , Howard M. Loree, II , Geoff Tansley , Steve Woodard , Barrett Hutto
CPC分类号： A61M1/3653 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/3655 , A61M1/3659 , A61M5/14236 , A61M2205/32 , A61M2205/3334
摘要： The present invention relates to a rotary blood pump with a double pivot contact bearing system with an operating range between about 50 mL/min and about 1500 mL/min. The rotary blood pump is part of a blood pump system that includes blood conduit(s), a control system with optional sensors, and a power source. Embodiments of the present invention may include elements such as wear resistant bearing materials, a rotor back plate for magnetic attraction of the rotor to reduce bearing pivot bearing forces and wear, a rotor size and shape and a bearing gap that combine to create a hydrodynamic bearing effect and reduce bearing pivot bearing forces and wear, improved intravascular conduits with increased resistance to thrombosis, conduit insertion site cuffs to resist infection, and conduit side ports amenable to the easy insertion of guidewire and catheter-based medical devices.
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