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1.发明申请BIOCONJUGATES MADE FROM RECOMBINANT N-GLYCOSYLATED PROTEINS FROM PROCARYOTIC CELLS 有权来自再生细胞的重组蛋白N-糖蛋白的生物素公开(公告)号：US20110097357A1
公开(公告)日：2011-04-28
申请号：US12735773
申请日：2009-02-19
IPC分类号： A61K39/385 , C12N15/63 , C12N1/21 , C12P21/00 , C07H21/00 , C07K14/21 , A61P37/04 , A61P31/04
CPC分类号： A61K39/0283 , A61K39/0258 , A61K39/104 , A61K39/105 , A61K39/385 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , C07K14/195 , C07K2319/034 , Y02A50/47 , Y02A50/474 , Y02A50/476
摘要： The present invention is directed to a bioconjugate vaccine, such as an 01-bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, D/E-X—N—Z—S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O1-bioconjugate in a bioreactor comprising a number steps.
摘要翻译： 本发明涉及生物共轭疫苗，例如01-生物缀合物疫苗，其包含：蛋白质载体，其包含含有至少一个共有序列的蛋白质载体，D / EX-N-Z-S / T，其中X和Z 可以是除脯氨酸以外的任何天然氨基酸; 至少一种与蛋白质载体连接的至少一种致病细菌的抗原性多糖; 和任选的佐剂。 在另一方面，本发明涉及在生物反应器中生产包含数个步骤的O1-生物缀合物的方法。
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2.发明授权Bioconjugates made from recombinant N-glycosylated proteins from procaryotic cells 有权由来自原核细胞的重组N-糖基化蛋白质制成的生物缀合物公开(公告)号：US08895014B2
公开(公告)日：2014-11-25
申请号：US12735773
申请日：2009-02-19
IPC分类号： A61K39/00 , A61K39/108 , A61K39/385 , C12N1/00 , C12N1/20 , C12N15/00 , A61K39/02 , A61K39/104 , C07K14/195 , A61K39/112
CPC分类号： A61K39/0283 , A61K39/0258 , A61K39/104 , A61K39/105 , A61K39/385 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , C07K14/195 , C07K2319/034 , Y02A50/47 , Y02A50/474 , Y02A50/476
摘要： The present invention is directed to a bioconjugate vaccine, such as an O1-bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, D/E-X-N-Z-S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O1-bioconjugate in a bioreactor comprising a number steps.
摘要翻译： 本发明涉及生物共轭疫苗，例如O1-生物缀合物疫苗，其包含：蛋白质载体，其包含含有至少一个共有序列D / EXNZS / T的蛋白质载体，其中X和Z可以是任何天然氨基酸 脯氨酸除外 至少一种与蛋白质载体连接的至少一种致病细菌的抗原性多糖; 和任选的佐剂。 另一方面，本发明涉及在生物反应器中生产包含数个步骤的O1-生物缀合物的方法。
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