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    Recombinant N-glycosylated proteins from procaryotic cells
    1.
    发明授权
    Recombinant N-glycosylated proteins from procaryotic cells 有权
    来自原核细胞的重组N-糖基化蛋白

    公开(公告)号：US08753864B2

    公开(公告)日：2014-06-17

    申请号：US11920175

    申请日：2006-05-10

    申请人： Markus Aebi ,  Michael Kowarik ,  Umesh Ahuja

    发明人： Markus Aebi ,  Michael Kowarik ,  Umesh Ahuja

    IPC分类号： A61K38/47 ,  C12N15/74 ,  A61K38/00

    CPC分类号： C12P21/005 ,  C07K14/205 ,  C07K14/25 ,  C07K2319/034 ,  C12N9/1051 ,  C12N15/70 ,  C12Y204/01

    摘要： The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells for preparing medicaments. Furthermore, the present invention provides methods for producing said proteins.

    摘要翻译： 本发明涉及重组N-糖基化蛋白质，其包含一个或多个引入的N-糖基化优化的氨基酸序列，编码这些蛋白质的核酸以及相应的载体和宿主细胞。 此外，本发明涉及所述蛋白质，核酸，载体和宿主细胞用于制备药物的用途。 此外，本发明提供了生产所述蛋白质的方法。

    Capsular gram-positive bacteria bioconjugate vaccines
    2.
    发明授权
    Capsular gram-positive bacteria bioconjugate vaccines 有权
    荚膜革兰氏阳性菌生物共轭疫苗

    公开(公告)号：US08871491B2

    公开(公告)日：2014-10-28

    申请号：US13100603

    申请日：2011-05-04

    申请人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    发明人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    IPC分类号： C12N1/20 ,  A61K39/085 ,  A61K39/00

    CPC分类号： A61K39/085 ,  A61K2039/505 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  A61K2039/70 ,  C07K14/21 ,  C07K16/1271 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/21 ,  C12N9/1029 ,  C12N9/1048 ,  C12N15/70 ,  C12N15/74 ,  Y02A50/47

    摘要： The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.

    摘要翻译： 本发明包括一种新型金黄色葡萄球菌生物缀合物疫苗。 更一般地，本发明涉及含有蛋白质载体，至少一种多糖例如荚膜革兰氏阳性多糖和任选的佐剂或药学上可接受的载体的革兰氏阳性和其他生物缀合物疫苗。 本发明还包括生产革兰氏阳性和其他生物缀合疫苗的方法。 还提供了含有一种或多种多糖如革兰氏阳性多糖的N-糖基化蛋白质。 本发明还涉及包含编码第一原核生物的糖基转移酶和第二原核生物的糖基转移酶的核苷酸序列的工程化原核生物。 本发明还包括用编码多糖的质粒和产生N-糖基化蛋白质和/或生物缀合物疫苗的酶转化的质粒和原核细胞。 此外，本发明涉及在哺乳动物中诱导免疫应答的方法，包括施用所述生物缀合物疫苗。

    CAPSULAR GRAM-POSITIVE BACTERIA BIOCONJUGATE VACCINES
    3.
    发明申请
    CAPSULAR GRAM-POSITIVE BACTERIA BIOCONJUGATE VACCINES 有权

    公开(公告)号：US20110274720A1

    公开(公告)日：2011-11-10

    申请号：US13100603

    申请日：2011-05-04

    申请人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    发明人： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

    IPC分类号： A61K39/085 ,  A61P37/02 ,  A61P31/04 ,  A61K39/116 ,  C07K14/00

    CPC分类号： A61K39/085 ,  A61K2039/505 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  A61K2039/70 ,  C07K14/21 ,  C07K16/1271 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/21 ,  C12N9/1029 ,  C12N9/1048 ,  C12N15/70 ,  C12N15/74 ,  Y02A50/47

    摘要： The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.

    摘要翻译： 本发明包括一种新型金黄色葡萄球菌生物缀合物疫苗。 更一般地，本发明涉及含有蛋白质载体，至少一种多糖例如荚膜革兰氏阳性多糖和任选的佐剂或药学上可接受的载体的革兰氏阳性和其他生物缀合物疫苗。 本发明还包括生产革兰氏阳性和其他生物缀合疫苗的方法。 还提供了含有一种或多种多糖如革兰氏阳性多糖的N-糖基化蛋白质。 本发明还涉及包含编码第一原核生物的糖基转移酶和第二原核生物的糖基转移酶的核苷酸序列的工程化原核生物。 本发明还包括用编码多糖的质粒和产生N-糖基化蛋白质和/或生物缀合物疫苗的酶转化的质粒和原核细胞。 此外，本发明涉及在哺乳动物中诱导免疫应答的方法，包括施用所述生物缀合物疫苗。