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1.发明申请公开(公告)号：US20130095093A1
公开(公告)日：2013-04-18
申请号：US13463127
申请日：2012-05-03
申请人： Joy Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley, III
发明人： Joy Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley, III
IPC分类号： A61K39/395
CPC分类号： A61K39/395 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K2039/505 , A61K2039/542 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C07K2317/77 , C12N2720/12334 , C12N2770/10034
摘要： Methods and compositions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglubulin or plasma fractions purified from animal serum can modulate serum IgG and/or TNF-α levels for treatment of autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译： 公开了调节动物免疫系统的方法和组合物。 申请人已经确定，从动物血清纯化的免疫凝集蛋白或血浆级分的口服给药可以调节血清IgG和/或TNF-α水平以治疗自身免疫性疾病，增强疫苗接种方案，以及提高包括人在内的动物（包括人）的整体健康和体重增加 。
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2.发明授权Nutritional supplement, method for increasing the bacterial mass in the rumen of a ruminant and nutritional preparation and corresponding uses 有权营养补充剂，增加反刍动物和营养制剂的瘤胃中的细菌质量的方法和相应的用途公开(公告)号：US09394356B2
公开(公告)日：2016-07-19
申请号：US14131098
申请日：2012-07-06
IPC分类号： C07K16/00 , C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K1/04 , A23K1/16 , A23K1/18 , A23L1/305 , A23K1/165
CPC分类号： C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K10/14 , A23K10/24 , A23K20/142 , A23K20/147 , A23K50/10 , A23K50/20 , A23L33/18 , A61K38/42
摘要： A nutritional supplement, a method for increasing the bacterial mass in the rumen of a ruminant and a nutritional preparation and corresponding uses. A nutritional supplement including proteins with a degree of hydrolysis above 28% and/or which have more than 23 mg α-amino nitrogen per gram of protein and/or have more than 10% of free amino acids. The hydrolyzed proteins are animal proteins, preferably hemoglobin. The supplement is supplied orally, included in a nutritional preparation, in liquid, concentrated or dehydrated form. The supplement is the basis for a method of increasing the bacterial mass in the rumen of a ruminant in which there is added to the ruminant's diet a supplement with these hydrolyzed proteins
摘要翻译： 营养补充剂，增加反刍动物和营养制剂的瘤胃中的细菌质量的方法和相应的用途。 包含水解度高于28％的蛋白质和/或每克蛋白质具有大于23mg的α-氨基氮和/或具有超过10％的游离氨基酸的营养补充剂。 水解的蛋白质是动物蛋白质，优选血红蛋白。 补充剂经口提供，包括在营养制剂中，液体，浓缩或脱水形式。 该补充物是增加反刍动物瘤胃中的细菌质量的基础，其中向反刍动物的饮食中加入这些水解蛋白质的补充物
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3.发明申请NUTRITIONAL SUPPLEMENT, METHOD FOR INCREASING THE BACTERIAL MASS IN THE RUMEN OF A RUMINANT AND NUTRITIONAL PREPARATION AND CORRESPONDING USES 有权营养补充剂，增加发酵剂和营养制剂和相关用途的酵母中的细菌的方法公开(公告)号：US20140171360A1
公开(公告)日：2014-06-19
申请号：US14131098
申请日：2012-07-06
IPC分类号： C07K14/805
CPC分类号： C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K10/14 , A23K10/24 , A23K20/142 , A23K20/147 , A23K50/10 , A23K50/20 , A23L33/18 , A61K38/42
摘要： A nutritional supplement, a method for increasing the bacterial mass in the rumen of a ruminant and a nutritional preparation and corresponding uses. A nutritional supplement including proteins with a degree of hydrolysis above 28% and/or which have more than 23 mg α-amino nitrogen per gram of protein and/or have more than 10% of free amino acids. The hydrolyzed proteins are animal proteins, preferably hemoglobin. The supplement is supplied orally, included in a nutritional preparation, in liquid, concentrated or dehydrated form. The supplement is the basis for a method of increasing the bacterial mass in the rumen of a ruminant in which there is added to the ruminant's diet a supplement with these hydrolyzed proteins
摘要翻译： 营养补充剂，增加反刍动物和营养制剂的瘤胃中的细菌质量的方法和相应的用途。 包含水解度高于28％的蛋白质和/或每克蛋白质具有大于23mg的α-氨基氮和/或具有超过10％的游离氨基酸的营养补充剂。 水解的蛋白质是动物蛋白质，优选血红蛋白。 补充剂经口提供，包括在营养制剂中，液体，浓缩或脱水形式。 该补充物是增加反刍动物瘤胃中的细菌质量的基础，其中向反刍动物的饮食中加入这些水解蛋白质的补充物
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4.发明申请METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASE-CHALLENGED ANIMALS 审中-公开用于治疗呼吸道疾病动物的方法和组合物公开(公告)号：US20120148570A1
公开(公告)日：2012-06-14
申请号：US13402291
申请日：2012-02-22
申请人： Joy M. Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley, III
发明人： Joy M. Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley, III
IPC分类号： A61K39/395 , A61P31/16 , A61P31/04 , A61P11/00
CPC分类号： C07K14/005 , A23K10/20 , A23K10/24 , A23K50/30 , A23K50/75 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , A61K2039/55516 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C07K2317/77 , C12N2720/12322 , C12N2720/12334 , C12N2770/10022 , C12N2770/10034
摘要： Methods and compostions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglobulins purified from animal blood can modulate the immune system for treatment of respiratory disease challenges, as well as modulate serum IgG levels for treatment of immune dysfunction disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译： 公开了用于调节动物免疫系统的方法和组合物。 申请人已经确定，从动物血液中纯化的免疫球蛋白的口服给药可以调节用于治疗呼吸系统疾病挑战的免疫系统，以及调节用于治疗免疫功能障碍的血清IgG水平，增强疫苗接种方案以及提高整体健康和体重 在动物，包括人类的增益。
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公开(公告)号：US20110135581A1
公开(公告)日：2011-06-09
申请号：US12992913
申请日：2009-05-22
申请人： Eric Weaver , Joy Campbell , Louis Russell , Miquel Moreto Pedragosa , Anna Perez-Bosque , Francisco Javier Polo Pozo , Joseph Crenshaw
发明人： Eric Weaver , Joy Campbell , Louis Russell , Miquel Moreto Pedragosa , Anna Perez-Bosque , Francisco Javier Polo Pozo , Joseph Crenshaw
IPC分类号： A61K39/395 , A61K9/12 , A61P11/00 , A61P11/06 , A61P37/00
CPC分类号： A61K35/16
摘要： The present invention provides methods for reducing, attenuating, diminishing, preventing or inhibiting pulmonary inflammation in an animal by orally administering a plasma fraction to said animal prior to or following exposure or challenge of the animal to an endotoxin.
摘要翻译： 本发明提供了在动物暴露或攻击内毒素之前或之后通过口服给予动物血浆级分来减少，减弱，减轻，预防或抑制动物肺部炎症的方法。
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6.发明申请公开(公告)号：US20080213263A1
公开(公告)日：2008-09-04
申请号：US11926442
申请日：2007-10-29
申请人： Joy Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley
发明人： Joy Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： C07K14/005 , A23K10/20 , A23K10/24 , A23K50/30 , A23K50/75 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , A61K2039/55516 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C07K2317/77 , C12N2720/12322 , C12N2720/12334 , C12N2770/10022 , C12N2770/10034
摘要： Methods and compositions are disclosed for modulating the immune system of animals. Applicants have identified that oral administration of immunoglobulin or plasma fractions purified from animal serum can modulate serum IgG and/or TNF-α levels for treatment of autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译： 公开了调节动物免疫系统的方法和组合物。 申请人已经确定，从动物血清纯化的免疫球蛋白或血浆级分的口服给药可以调节血清IgG和/或TNF-α水平以治疗自身免疫性疾病，增强疫苗接种方案，以及提高包括人在内的动物的整体健康和体重增加 。
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7.发明申请公开(公告)号：US20080138340A1
公开(公告)日：2008-06-12
申请号：US11926419
申请日：2007-10-29
申请人： Joy M. Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley
发明人： Joy M. Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley
IPC分类号： A61K39/395 , A61K39/02 , A61P11/00 , A61K39/00
CPC分类号： C07K14/005 , A23K10/20 , A23K10/24 , A23K50/30 , A23K50/75 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , A61K2039/55516 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C07K2317/77 , C12N2720/12322 , C12N2720/12334 , C12N2770/10022 , C12N2770/10034
摘要： Methods and compositions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglobulins purified from animal blood can modulate serum IgG levels for treatment of immune dysfunction disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译： 公开了调节动物免疫系统的方法和组合物。 申请人已经确定，从动物血液中纯化的免疫球蛋白的口服给药可调节用于治疗免疫功能障碍的血清IgG水平，增强疫苗接种方案，以及改善包括人在内的动物的整体健康和体重增加。
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公开(公告)号：US06749872B2
公开(公告)日：2004-06-15
申请号：US10061478
申请日：2002-02-01
IPC分类号： A23J106
CPC分类号： A23K50/00 , A23K20/132 , A23K20/30 , Y10S426/805 , Y10S426/807
摘要： A feed supplement is disclosed comprising heme purified from animal blood. Animals fed this supplement experience a significantly lower average daily gain and average daily feed intake when compared with feed supplemented with fishmeal or AP 301. Only the animals fed the heme supplement exhibit improved meat quality, including improved meat color and drip loss.
摘要翻译： 公开了一种饲料添加剂，其包含从动物血液中纯化的血红素。 与补充鱼粉或AP301的饲料相比，补充这种补充剂的动物的平均日增重和平均日采食量显着降低。只有饲喂血红素补充剂的动物才能改善肉质，包括改善肉色和滴水损失。
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公开(公告)号：US09616091B2
公开(公告)日：2017-04-11
申请号：US12992913
申请日：2009-05-22
申请人： Eric Weaver , Joy Campbell , Louis Russell , Miquel Moreto Pedragosa , Anna Perez-Bosque , Francisco Javier Polo Pozo , Joseph Crenshaw
发明人： Eric Weaver , Joy Campbell , Louis Russell , Miquel Moreto Pedragosa , Anna Perez-Bosque , Francisco Javier Polo Pozo , Joseph Crenshaw
IPC分类号： A61K35/16
CPC分类号： A61K35/16
摘要： The present invention provides methods for reducing, attenuating, diminishing, preventing or inhibiting pulmonary inflammation in an animal by orally administering a plasma fraction comprising at least 30% by weight IgG and 10% or less by weight IgA to said animal prior to or following exposure or challenge of the animal to an endotoxin.
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10.发明申请METHODS AND COMPOSITIONS OF TREATMENT FOR MODULATING THE IMMUNE SYSTEM OF ANIMALS 审中-公开用于调节动物免疫系统的方法和组合物公开(公告)号：US20100215667A1
公开(公告)日：2010-08-26
申请号：US12723440
申请日：2010-03-12
申请人： Joy M. Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley, III
发明人： Joy M. Campbell , Ronald E. Strohbehn , Eric M. Weaver , Barton S. Borg , Louis E. Russell , Francisco Javier Polo Pozo , John D. Arthington , James D. Quigley, III
IPC分类号： A61K39/42 , A61K39/395 , A61P19/02 , A61P3/10 , A61P27/02 , A61P11/06 , A61P7/00 , A61P25/00
CPC分类号： A61K39/15 , A23K10/00 , A61K35/16 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C12N2720/12334 , C12N2770/10011 , C12N2770/10034
摘要： Methods and compositions are disclosed for the dietary modulation of the immune system and gut microbial response in animals. Applicant has identified that oral administration of a supplemental spray dried plasma purified from animal serum can modulate serum IgG levels for treatment in such things as diminished immune capacity, intestinal microbial balance, autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译： 公开了用于免疫系统的饮食调节和动物肠内微生物反应的方法和组合物。 申请人已经确定，从动物血清中纯化的补充喷雾干燥血浆的口服给药可以调节血清IgG水平以进行治疗，例如免疫能力降低，肠微生物平衡，自身免疫疾病，增强疫苗接种方案以及提高整体健康和体重 在动物，包括人类的增益。
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