公开(公告)号：US09109996B2

公开(公告)日：2015-08-18

申请号：US13636337

申请日：2011-03-23

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： G01N29/02 ,  G01N11/16 ,  G01N29/036 ,  G01N29/22

CPC分类号： G01N29/022 ,  G01N11/16 ,  G01N29/036 ,  G01N29/222 ,  G01N29/226 ,  G01N2291/0426

摘要： The invention relates to a measuring device (10, 50) comprising a resonator (20, 52) having a sensitive) being inserted in the region and a base support unit (26, 30) for measuring properties of a fluid, the resonator (20, 52base support unit (26, 30) and contacted therein, the sensitive region remaining accessible to the fluid, and the resonator (20, 52) being activatable via connection points (24, 40) on the base support unit (26, 30). The invention is characterized in that the base support unit (26, 30) is formed solely by a film arrangement.

摘要翻译： 本发明涉及一种测量装置（10,50），包括一个敏感的谐振器（20,52）被插入该区域，以及一个用于测量流体特性的基座支撑单元（26,30），该谐振器 ，52基座支撑单元（26,30）并且与其接触，所述敏感区域可被流体接近，并且所述谐振器（20,52）可通过所述基座支撑单元（26,30）上的连接点（24,40）激活， 本发明的特征在于，基座支撑单元（26,30）仅由薄膜装置形成。

公开(公告)号：US20120252043A1

公开(公告)日：2012-10-04

申请号：US13394807

申请日：2010-09-09

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： G01N33/86 ,  C12M1/34 ,  C12Q1/56

CPC分类号： G01N29/036 ,  G01N33/86 ,  G01N2291/0256

摘要： The invention relates to a method for determining the coagulation time of a sample fluid containing blood components by means of a resonator whose vibration parameters are measured and then used as a basis for determining the sample fluid viscosity change, which resonator has an at least partially adhesive surface contacting said sample fluid. The invention is characterized by preincubation of said surface with a preincubation fluid containing blood components, which preincubation fluid has a known way of interacting with the coagulation system, thus resulting in anchoring sites to be formed on the adhesive areas of said surface.

摘要翻译： 本发明涉及一种用于通过谐振器测定含有血液成分的样品流体的凝固时间的方法，所述共振器的振动参数被测量，然后用作确定样品流体粘度变化的基础，该共振器具有至少部分粘合剂 表面接触所述样品流体。 本发明的特征在于，所述表面用含有血液成分的预温育液预温育，其中预温育液体具有已知的与凝固系统相互作用的方式，从而导致待形成在所述表面的粘合区域上的锚固部位。

公开(公告)号：US09366652B2

公开(公告)日：2016-06-14

申请号：US13394807

申请日：2010-09-09

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： A61B5/00 ,  G01N29/036 ,  G01N33/86

CPC分类号： G01N29/036 ,  G01N33/86 ,  G01N2291/0256

摘要： The invention relates to a method for determining the coagulation time of a sample fluid containing blood components by means of a resonator whose vibration parameters are measured and then used as a basis for determining the sample fluid viscosity change, which resonator has an at least partially adhesive surface contacting said sample fluid. The invention is characterized by preincubation of said surface with a preincubation fluid containing blood components, which preincubation fluid has a known way of interacting with the coagulation system, thus resulting in anchoring sites to be formed on the adhesive areas of said surface.

摘要翻译： 本发明涉及一种用于通过谐振器测定含有血液成分的样品流体的凝固时间的方法，所述共振器的振动参数被测量，然后用作确定样品流体粘度变化的基础，该共振器具有至少部分粘合剂 表面接触所述样品流体。 本发明的特征在于，所述表面用含有血液成分的预温育液预温育，其中预温育液体具有已知的与凝固系统相互作用的方式，从而导致待形成在所述表面的粘合区域上的锚固部位。

公开(公告)号：US08920702B2

公开(公告)日：2014-12-30

申请号：US13526677

申请日：2012-06-19

申请人： Thomas Hipp ,  Frank K. Gehring

发明人： Thomas Hipp ,  Frank K. Gehring

IPC分类号： B29C39/08 ,  B29C33/42 ,  B29C39/26 ,  B29C41/04 ,  B29C39/00 ,  B29C35/02 ,  B29C35/08 ,  B29C37/00 ,  B29L31/00 ,  B29C39/28

CPC分类号： B29C39/08 ,  B29C33/424 ,  B29C35/02 ,  B29C35/0888 ,  B29C37/0053 ,  B29C37/006 ,  B29C39/006 ,  B29C39/26 ,  B29C39/28 ,  B29C41/04 ,  B29C41/045 ,  B29C2035/0827 ,  B29L2031/756

摘要： The invention relates to a method and a device for producing a molded body having microstructures from molding material. The method for producing a molded body having microstructures on a carrier out of molding material is effected by inputting a molding material into a container (10) comprising a mold cavity (14), wherein at least one micro-structured mold (12) is provided in the mold cavity. Furthermore, the centrifugation of a container (10) is carried out until the molding material has completely entered into the structure of the mold (12). Thereafter, the curing of the molding material is carried out to form a molded body having microstructures, which is then removed from the mold (12) and the container (10).

摘要翻译： 本发明涉及一种用于生产具有来自成型材料的微结构的成型体的方法和装置。 通过将成型材料输入到包括模腔（14）的容器（10）中来实现在模制材料上具有在载体上具有微结构的成型体的方法，其中提供至少一个微结构的模具（12） 在模腔中。 此外，进行容器（10）的离心，直到模制材料完全进入模具（12）的结构。 此后，进行成型材料的固化，形成具有微结构的成型体，然后将其从模具（12）和容器（10）中取出。

公开(公告)号：US08756981B2

公开(公告)日：2014-06-24

申请号：US13053136

申请日：2011-03-21

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： G01N29/00

CPC分类号： G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/02818 ,  G01N2291/02863 ,  G01N2291/0426

摘要： The invention relates to a measurement device with at least one resonator, comprising a measurement chamber with a fluidic input and a fluidic output wherein the measurement chamber is delimited, at its bottom surface, by a resonator, and wherein the resonator surface is configured to be electrically conducting, and the resonator surface forms the working electrode for an electrochemical measurement, and wherein electrodes are provided at the fluidic input and/or output at the transition to the measurement chamber. The invention is characterized in that the electrodes are exchangeable and allow the reception of a fluidic connection.

摘要翻译： 本发明涉及一种具有至少一个谐振器的测量装置，包括具有流体输入和流体输出的测量室，其中测量室在其底表面处由谐振器限定，并且其中所述谐振器表面被配置为 并且谐振器表面形成用于电化学测量的工作电极，并且其中电极设置在过渡到测量室处的流体输入和/或输出处。 本发明的特征在于，电极是可交换的并且允许接收流体连接。

公开(公告)号：US20090173158A1

公开(公告)日：2009-07-09

申请号：US12294959

申请日：2007-03-28

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： G01N29/036

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N29/222 ,  G01N2291/018 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0422

摘要： The invention relates to an apparatus comprising a measurement chamber and a resonator, which can be integrated in the measurement chamber via a quick-action closure, for the liquid sensor system and for verification and measurement of the concentration of materials, substances, particles and/or microorganisms in liquids. The invention is characterized in that the resonator is held only on its outer circumference by a thin elastomer ring, and in that at the radial distance of the external diameter of the resonator, the elastomer ring on the one hand rests on an upper sealing ring of the measurement chamber, forming a seal, and on the other hand rests on a holding ring.

摘要翻译： 本发明涉及一种包括测量室和谐振器的装置，其可以通过用于液体传感器系统的快速闭合而集成在测量室中，并且用于验证和测量材料，物质，颗粒和/ 或液体中的微生物。 本发明的特征在于，谐振器仅通过薄的弹性体环保持在其外周上，并且在谐振器的外径的径向距离处，弹性体环一方面靠在上密封环 测量室形成密封，另一方面搁置在保持环上。

公开(公告)号：US20130125629A1

公开(公告)日：2013-05-23

申请号：US13636337

申请日：2011-03-23

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： G01N29/02

CPC分类号： G01N29/022 ,  G01N11/16 ,  G01N29/036 ,  G01N29/222 ,  G01N29/226 ,  G01N2291/0426

摘要： The invention relates to a measuring device (10, 50) comprising a resonator (20, 52) having a sensitive region and a base support unit (26, 30) for measuring properties of a fluid, the resonator (20, 52) being inserted in the base support unit (26, 30) and contacted therein, the sensitive region remaining accessible to the fluid, and the resonator (20, 52) being activatable via connection points (24, 40) on the base support unit (26, 30). The invention is characterized in that the base support unit (26, 30) is formed solely by a film arrangement.

摘要翻译： 本发明涉及一种包括具有敏感区域的谐振器（20,52）和用于测量流体性质的基座支撑单元（26,30）的测量装置（10,50），所述谐振器（20,52）被插入 在所述基座支撑单元（26,30）中并且接触到所述流体的所述敏感区域，并且所述谐振器（20,52）可通过所述基座支撑单元（26,30）上的连接点（24,40） ）。 本发明的特征在于，基座支撑单元（26,30）仅由薄膜装置形成。

公开(公告)号：US20120270326A1

公开(公告)日：2012-10-25

申请号：US13394550

申请日：2010-09-09

申请人： Frank K. Gehring ,  Hans Wendel ,  Stefan Sinn ,  Lothar Mueller

发明人： Frank K. Gehring ,  Hans Wendel ,  Stefan Sinn ,  Lothar Mueller

IPC分类号： G01N29/44

CPC分类号： G01N29/036 ,  G01N33/86 ,  G01N2291/0256

摘要： The invention relates to a method for determining haemostasis parameters by measuring vibration parameters of a resonator having a measuring surface which contacts a platelet containing sample fluid. The invention is characterized by the analysis of the characteristic of a vibration parameter over time, based on which the platelet function will then be assessed and a distinction will be made between the presence of an adhesion disorder or that of an aggregation disorder.

摘要翻译： 本发明涉及一种通过测量具有接触含血小板样品流体的测量表面的谐振器的振动参数来确定止血参数的方法。 本发明的特征在于分析随时间的振动参数的特征，基于此，将评估血小板功能，并且将区分粘附障碍或聚集障碍的存在。

公开(公告)号：US08230724B2

公开(公告)日：2012-07-31

申请号：US12294959

申请日：2007-03-28

申请人： Frank K. Gehring

发明人： Frank K. Gehring

IPC分类号： G01H13/00 ,  G01N29/036

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N29/222 ,  G01N2291/018 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0422

摘要： The invention relates to an apparatus comprising a measurement chamber and a resonator, which can be integrated in the measurement chamber via a quick-action closure, for the liquid sensor system and for verification and measurement of the concentration of materials, substances, particles and/or microorganisms in liquids. The invention is characterized in that the resonator is held only on its outer circumference by a thin elastomer ring, and in that at the radial distance of the external diameter of the resonator, the elastomer ring on the one hand rests on an upper sealing ring of the measurement chamber, forming a seal, and on the other hand rests on a holding ring.

摘要翻译： 本发明涉及一种包括测量室和谐振器的装置，其可以通过用于液体传感器系统的快速闭合而集成在测量室中，并且用于验证和测量材料，物质，颗粒和/ 或液体中的微生物。 本发明的特征在于，谐振器仅通过薄的弹性体环保持在其外周上，并且在谐振器的外径的径向距离处，弹性体环一方面靠在上密封环 测量室形成密封，另一方面搁置在保持环上。

公开(公告)号：US20110232783A1

公开(公告)日：2011-09-29

申请号：US13053212

申请日：2011-03-22

申请人： FRANK K. GEHRING

发明人： FRANK K. GEHRING

IPC分类号： F15D1/00

CPC分类号： F04B49/065 ,  A61M5/142 ,  F04B53/16 ,  Y10T137/8376

摘要： The invention relates to an apparatus (10) for fluid supply and control of a fluidic system comprising a housing (12), a control unit integrated into the housing (12), as well as at least one pump integrated into the housing (12) and at least one valve integrated into the housing (12) which are connected to the control unit by signal technology and which are adapted to be controlled by the control unit, wherein the housing (12) comprises a connection plate (24, 26) comprising standardized fluidic connection means (14, 16, 20) accessible from the outside for connected external fluidic connections, and wherein the at least one pump and the at least one valve (22) are connected to the connection means (14, 16, 20) of the connection plate (24, 26) in the interior of the housing (12).

摘要翻译： 本发明涉及一种用于流体供应和控制流体系统的设备（10），其包括壳体（12），集成到壳体（12）中的控制单元以及集成到壳体（12）中的至少一个泵， 以及集成到所述壳体（12）中的至少一个阀，其通过信号技术连接到所述控制单元并且适于由所述控制单元控制，其中所述壳体（12）包括连接板（24,26），所述连接板包括 标准化的流体连接装置（14,16,20），其可从外部接近用于连接的外部流体连接，并且其中所述至少一个泵和所述至少一个阀（22）连接到所述连接装置（14,16,20） 的连接板（24,26）在壳体（12）的内部。