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    N-[4-(1H-PYRAZOLO[3,4-b]PYRAZIN-6-YL)-PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS
    1.
    发明申请
    N-[4-(1H-PYRAZOLO[3,4-b]PYRAZIN-6-YL)-PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS 审中-公开
    N- [4-（1H-吡唑并[3,4-b]吡嗪-6-基） - 苯基] - 磺酰胺及其作为药物的用途

    公开(公告)号：US20130072493A1

    公开(公告)日：2013-03-21

    申请号：US13236027

    申请日：2011-09-19

    申请人： Marc NAZARE ,  Nis Halland ,  Friedemann Schmidt ,  Tilo Weiss ,  Uwe Dietz ,  Armin Hofmeister

    发明人： Marc NAZARE ,  Nis Halland ,  Friedemann Schmidt ,  Tilo Weiss ,  Uwe Dietz ,  Armin Hofmeister

    IPC分类号： A61K31/4985 ,  A61P19/02 ,  A61P19/04 ,  A61P9/10 ,  A61P9/00 ,  A61P43/00 ,  A61P29/00 ,  A61P35/00 ,  C07D487/04 ,  A61P3/10

    CPC分类号： A61K31/4985 ,  C07D487/04

    摘要： The present invention relates to N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides of the formula I, wherein Ar, R1, R2 and n have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds which modulate protein kinase activity, specifically the activity of serum and glucocorticoid regulated kinase (SGK), in particular of serum and glucocorticoid regulated kinase isoform 1 (SGK-1, SGK1), and are suitable for the treatment of diseases in which SGK activity is inappropriate, for example degenerative joint disorders or inflammatory processes such as osteoarthritis or rheumatism. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

    摘要翻译： 本发明涉及式I的N- [4-（1H-吡唑并[3,4-b]吡嗪-6-基） - 苯基] - 磺酰胺，其中Ar，R 1，R 2和n具有如 索赔。 式I的化合物是调节蛋白激酶活性，特别是血清和糖皮质激素调节激酶（SGK）的活性，特别是血清和糖皮质激素调节激酶同工型1（SGK-1，SGK1）的活性的有价值的药理活性化合物，并且是 适合于治疗SGK活动不适当的疾病，例如退行性关节疾病或炎性过程如骨关节炎或风湿病。 本发明还涉及式I化合物的制备方法，它们作为药物的用途，以及包含它们的药物组合物。

    DIFFERENTIAL INTERFACE FOR INTER-DEVICE COMMUNICATION IN A BATTERY MANAGEMENT AND PROTECTION SYSTEM
    3.
    发明申请
    DIFFERENTIAL INTERFACE FOR INTER-DEVICE COMMUNICATION IN A BATTERY MANAGEMENT AND PROTECTION SYSTEM 有权
    电池管理和保护系统中设备间通信的差异接口

    公开(公告)号：US20130264881A1

    公开(公告)日：2013-10-10

    申请号：US13442502

    申请日：2012-04-09

    申请人： Wolfgang Roeper ,  Hendrik Ahlendorf ,  Friedemann Schmidt

    发明人： Wolfgang Roeper ,  Hendrik Ahlendorf ,  Friedemann Schmidt

    IPC分类号： H02J1/00

    CPC分类号： H02J7/0026 ,  H02J7/00 ,  H02J7/0014 ,  H04L7/02 ,  H04L7/033 ,  H04L25/0282 ,  H04L25/0294 ,  H04L25/4904 ,  Y10T307/685

    摘要： A multi-cell battery stack includes a microcontroller and a string of battery management and protection IC devices connected to one another in a daisy chain configuration. Each battery management and protection IC device can include a communication interface circuit includes pairs of differential input signal lines, receivers including respective current comparator circuits to receive differential signals on the differential input signal lines, and transmitters to provide outgoing differential signals on the differential input signal lines. A digital circuit block allows signals to pass between the receivers and transmitters.

    摘要翻译： 多单元电池堆包括一个微控制器和一串电池管理和保护IC装置，以菊花链的形式相互连接。 每个电池管理和保护IC器件可以包括通信接口电路，包括差分输入信号线对，包括用于在差分输入信号线上接收差分信号的各个电流比较器电路的接收器，以及在差分输入信号上提供输出差分信号的发射器 线条。 数字电路块允许信号在接收器和发射器之间通过。

    Electrostatic discharge circuit layout
    5.
    发明授权
    Electrostatic discharge circuit layout 失效
    静电放电电路布局

    公开(公告)号：US5748425A

    公开(公告)日：1998-05-05

    申请号：US732994

    申请日：1996-10-16

    申请人： Henrik Gutsch ,  Horst Hafner ,  Hermann Hammel ,  Friedemann Schmidt ,  Jurgen Schnabel

    发明人： Henrik Gutsch ,  Horst Hafner ,  Hermann Hammel ,  Friedemann Schmidt ,  Jurgen Schnabel

    IPC分类号： H02H9/04 ,  H02H9/00

    CPC分类号： H02H9/046

    摘要： In order to protect against any damage caused by electrostatic discharges, an integrated circuit layout is provided with at least one circuit connection which is connected via one of two diodes, respectively, to a first supply line and a second supply line. The diodes are reverse biased, i.e., one of them becomes conductive if a potential exists at the circuit connection that is either higher or lower than the supply potentials applying to the supply lines. The circuit layout is provided with an overvoltage suppression device connecting the two supply lines. The overvoltage suppression device is switched into a low impedance state by a steep rate increase or rise in a supply voltage applied between the supply lines such that a discharge current counteracting the increase in the supply voltage will flow via the overvoltage suppression device from the one supply line to the other supply line, and the discharge energy is converted into heat in the overvoltage suppression device.

    摘要翻译： 为了防止由静电放电引起的任何损害，集成电路布局设置有至少一个电路连接，其分别经由两个二极管中的一个连接到第一电源线和第二电源线。 二极管是反向偏置的，即如果在电路连接处存在电位高于或低于施加到电源线的电源电位，则其中的一个变为导通。 电路布局设有连接两条电源线的过电压抑制装置。 过电压抑制装置通过陡峭的速率增加或施加在电源线之间的电源电压的上升而被切换到低阻抗状态，使得抵消电源电压的增加的放电电流将经由过电压抑制装置从一个电源 线路到另一条供电线路，并且放电能量在过电压抑制装置中被转换成热量。