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    DETERMINING PROTEIN-TO-PROTEIN INTERACTIONS
    1.
    发明申请
    DETERMINING PROTEIN-TO-PROTEIN INTERACTIONS 有权

    公开(公告)号：US20250125006A1

    公开(公告)日：2025-04-17

    申请号：US18918695

    申请日：2024-10-17

    Applicant: George Mason University

    Inventor： Mohsin Saleet Jafri ,  Leena Nezamuldeen

    IPC: G16B15/30 ,  G16H20/10

    Abstract: A method includes: receiving information containing a name of a target protein associated with a disease, a name of a variant of the target protein, and a type of mutation associated with a disease; deriving, based on the information, a plurality of lists comprising: a first list containing protein names, a second list containing names of the genetic variant and protein post-translational modification type, a third list containing domain name, and a fourth list containing region name; generating search queries based on combinations of contents of the lists; gathering a plurality of text descriptions which satisfy the search queries, where the text descriptions include descriptions of relations of the target protein with other proteins; and identifying, based on processing the text descriptions, a suggested drug for treating the disease, where the suggested drug is associated with at least one of the other proteins.

    Dynamically deployable low-visibility pneumatic cofferdam system, method and apparatus
    2.
    发明授权
    Dynamically deployable low-visibility pneumatic cofferdam system, method and apparatus 有权

    公开(公告)号：US12195937B2

    公开(公告)日：2025-01-14

    申请号：US17702194

    申请日：2022-03-23

    Applicant: George Mason University

    Inventor： George Lee Donohue ,  Adel N. Youssef ,  Lucciana Hind Remy ,  Faris Khaled Masri ,  Murat Gokturk

    IPC: E02B3/16 ,  E02D19/04

    Abstract: A dynamically deployable, low visibility pneumatic cofferdam for flood mitigation is disclosed. The cofferdam includes a first planar component, a second planar component, an inflatable hermetic airbag sandwiched therebetween, and connection members attached to the first planar component, a second planar component to form a cofferdam unit. The connection members are adjustable to apply and maintain a desired amount of pressure on the airbag to enable a watertight seal to be formed. The cofferdam units may be sized and designed to sealingly mate adjacent cofferdam units in a variety of configurations to form watertight seals. The cofferdam units may also be sized and designed to attach to seawalls, flood walls, sidewalks, or other infrastructure. When in a deployed state, the height of the cofferdam may be adjusted to a desired height to provide flood mitigation. When in an undeployed state, the cofferdam remains in a substantially flat and unobtrusive position.

    METHODS AND SYSTEMS FOR SECURITY SOFTWARE PATCH TYPE DETECTION
    3.
    发明申请
    METHODS AND SYSTEMS FOR SECURITY SOFTWARE PATCH TYPE DETECTION 有权

    公开(公告)号：US20240411886A1

    公开(公告)日：2024-12-12

    申请号：US18431443

    申请日：2024-02-02

    Applicant: George Mason University

    Inventor： Kun Sun ,  Xinda Wang ,  Shu Wang

    IPC: G06F21/57 ,  G06F8/65

    Abstract: Methods and systems are provided for security patch type detection of software patches. A software patch for a software product may be received. For example, the software patch may be received by a computing device. A pre-patch code property graph and a post-patch code property graph may be determined. For example, the pre-patch code property graph and the post-patch code property graph may be determined based on the software patch and/or the pre-patch source code and the post-patch source code respectively. A combined patch code property graph may be determined. For example, the combined patch code property graph may be determined based on the pre-patch code property graph and the post-patch code property graph. A patch type for the software patch may be determined. For example, the patch type may be determined based on the combined patch code property graph and/or a machine-learning prediction model.

    SYSTEMS AND METHODS FOR KNOWLEDGE DISCOVERY FROM DATA AND PRIOR KNOWLEDGE
    10.
    发明公开
    SYSTEMS AND METHODS FOR KNOWLEDGE DISCOVERY FROM DATA AND PRIOR KNOWLEDGE 审中-公开

    公开(公告)号：US20240037421A1

    公开(公告)日：2024-02-01

    申请号：US18227443

    申请日：2023-07-28

    Applicant: George Mason University

    Inventor： Gheorghe Tecuci

    IPC: G06N5/022

    CPC classification number: G06N5/022

    Abstract: A system for knowledge discovery includes a processor and a memory. The memory includes instructions which, when executed by the processor, cause the system to: access a reference case of a plurality of cases; generate argumentation explaining a phenomenon of the reference case by developing a predictive model; generate a knowledge-based generalization of the argumentation; apply the argumentation to a plurality of cases similar to the reference case based on knowledge-based search and classification; split the plurality of similar cases into a plurality of favoring cases and a plurality of disfavoring cases; select a disfavoring case based on a similarity of factors; determine what factors were not taken into account in generating the argumentation; and generate a hypothesis-driven explanation theory based on comparing one or more features of the reference case to one or more features of the most disfavoring case.

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