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1.发明授权Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists 失效酰胺衍生物和使用它们作为选择性神经肽Y受体拮抗剂的方法公开(公告)号：US06410792B1
公开(公告)日：2002-06-25
申请号：US09294961
申请日：1999-04-20
IPC分类号： C07C21100
CPC分类号： A61K31/00
摘要： Amide derivatives and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.
摘要翻译： 酰胺衍生物和将组合物施用于哺乳动物以治疗由NPY介导的疾病如肥胖的方法，特别是通过Y5受体由NPY介导的那些。
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2.发明授权
公开(公告)号：US6048900A
公开(公告)日：2000-04-11
申请号：US23498
申请日：1998-02-13
CPC分类号： A61K31/00
摘要： Amide derivatives and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.
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公开(公告)号：US06245817B1
公开(公告)日：2001-06-12
申请号：US09295073
申请日：1999-04-20
IPC分类号： A01N3302
CPC分类号： A61K31/00
摘要： &agr;-alkoxy and &agr;-thioalkoxyamide compositions and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.
摘要翻译： α-烷氧基和α-硫代烷氧基酰胺组合物以及将组合物施用于哺乳动物以治疗由NPY介导的疾病如肥胖的方法，特别是通过Y5受体由NPY介导的那些。
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公开(公告)号：US5939462A
公开(公告)日：1999-08-17
申请号：US023351
申请日：1998-02-13
IPC分类号： C07D249/14 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/195 , A61K31/196 , A61K31/20 , A61K31/201 , A61K31/215 , A61K31/275 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/433 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/00 , A61P9/12 , A61P11/00 , A61P15/00 , A61P25/04 , A61P43/00 , C07C237/04 , C07D207/08 , C07D207/10 , C07D207/16 , C07D209/02 , C07D209/16 , C07D209/52 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/48 , C07D211/50 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/38 , C07D213/56 , C07D213/74 , C07D233/64 , C07D235/26 , C07D285/14 , C07D295/12 , C07D295/15 , C07D295/20 , C07D307/52 , C07D317/58 , C07D401/04 , C07D405/14 , C07D471/10 , A01N33/08
CPC分类号： C07D213/74 , A61K31/00 , A61K31/454 , C07C237/04 , C07D207/16 , C07D209/52 , C07D211/66 , C07D213/56 , C07D295/15 , C07D401/04
摘要： .alpha.-alkoxy and .alpha.-thioalkoxyamide compositions and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.
摘要翻译： α-烷氧基和α-硫代烷氧基酰胺组合物以及将组合物施用于哺乳动物以治疗由NPY介导的疾病如肥胖的方法，特别是通过Y5受体由NPY介导的那些。
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公开(公告)号：US06218431B1
公开(公告)日：2001-04-17
申请号：US08904119
申请日：1997-07-31
申请人： William R. Schoen , Gaetan H. Ladouceur , James H. Cook, II , Timothy G. Lease , Donald J. Wolanin , Richard H. Kramss , Donald L. Hertzog , Martin H. Osterhout
发明人： William R. Schoen , Gaetan H. Ladouceur , James H. Cook, II , Timothy G. Lease , Donald J. Wolanin , Richard H. Kramss , Donald L. Hertzog , Martin H. Osterhout
IPC分类号： A61K31275
CPC分类号： C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D213/50 , C07D213/55 , C07D213/64 , C07D213/70 , C07D213/74 , C07D213/80 , C07D215/14 , C07D221/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D411/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D487/04 , C07F7/1804
摘要： Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formula wherein R1a and R1b independently represent (C1-C6) alkyl; R2 represents (C1-C10) alkyl or substituted (C1-C10) alkyl wherein the substituents are independently from 1 to 3 of —SR7; R7 represents phenyl, or substituted phenyl wherein the substituents are independently 1-5 of halogen, trifluoromethyl, (C1-C6) alkyl, (C1-C6) alkoxy, nitro, cyano, or hydroxyl; R3 represents substituted (C1-C6) alkyl wherein the substituents are 1-2 hydroxyl groups; G represents a substituent selected from the group consisting of halogen, (C1-C6) alkyl, and OR4 wherein R4 is H or (C1-C6) alkyl; and y is 0 or an integer of 1-3. Pharmaceutical compositions containing such compounds and methods of treatment of glucagon-mediated conditions by administering such compounds are also claimed.
摘要翻译： 具有胰高血糖素受体拮抗活性的取代的联苯。 权利要求的化合物具有R1a和R1b独立地表示（C1-C6）烷基; R2代表（C1-C10）烷基或取代的（C1-C10）烷基，其中取代基独立地为1至3的-SR7; R7代表苯基或取代苯基，其中取代基独立地为1-5个卤素，三氟甲基，（C1-C6）烷基，（C1-C6）烷氧基，硝基，氰基或羟基; R3表示取代基（C1-C6）烷基，其中取代基是1-2个羟基; G表示选自卤素，（C1-C6）烷基和OR4的取代基，其中R4是H或（C1-C6）烷基; y为0或1-3的整数。 还要求保护含有这些化合物的药物组合物和通过施用这些化合物治疗胰高血糖素介导的病症的方法。
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公开(公告)号：US06903218B2
公开(公告)日：2005-06-07
申请号：US10667286
申请日：2003-09-19
申请人： Gaetan H. Ladouceur , Richard D. Connell , Jeremy Baryza , Ann-Marie Campbell , Timothy G. Lease , James H. Cook
发明人： Gaetan H. Ladouceur , Richard D. Connell , Jeremy Baryza , Ann-Marie Campbell , Timothy G. Lease , James H. Cook
IPC分类号： C07D213/30 , C07D213/50 , C07D213/61 , C07D233/70 , C07D257/04 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04
CPC分类号： C07D213/30 , C07D213/50 , C07D213/61 , C07D233/70 , C07D257/04 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04
摘要： This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3受体介导的病症的新型磺酰胺取代的苯并二氢吡喃衍生物。
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7.发明授权Sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists 失效用作β3肾上腺素受体激动剂的磺酰胺取代的苯并二氢吡喃衍生物
公开(公告)号：US6051586A
公开(公告)日：2000-04-18
申请号：US199014
申请日：1998-11-23
申请人： Gaetan H. Ladouceur , Richard D. Connell , Jeremy Baryza , Ann-Marie Campbell , Timothy G. Lease , James H. Cook
发明人： Gaetan H. Ladouceur , Richard D. Connell , Jeremy Baryza , Ann-Marie Campbell , Timothy G. Lease , James H. Cook
IPC分类号： C07D213/30 , C07D213/50 , C07D213/61 , C07D233/70 , C07D257/04 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , A61K31/353 , C07D407/12
CPC分类号： C07D213/30 , C07D213/50 , C07D213/61 , C07D233/70 , C07D257/04 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04
摘要： This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3受体介导的病症的新型磺酰胺取代的苯并二氢吡喃衍生物。
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8.发明授权2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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9.发明授权Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders 失效用于治疗高增殖性疾病的取代的四氢苯并噻吩嘧啶胺化合物公开(公告)号：US07238701B2
公开(公告)日：2007-07-03
申请号：US10557090
申请日：2004-07-23
申请人： Chengzhi Zhang , Gaetan H. Ladouceur , Catherine Brennan , Brent Chandler , Julie A. Dixon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
发明人： Chengzhi Zhang , Gaetan H. Ladouceur , Catherine Brennan , Brent Chandler , Julie A. Dixon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00
CPC分类号： C07D495/04 , C07D498/02
摘要： The present invention relates to a compound of Formula (I) and its use in treating lung and breast cancer.
摘要翻译： 本发明涉及式（I）化合物及其在治疗肺癌和乳腺癌中的用途。
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10.发明授权2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06660752B2
公开(公告)日：2003-12-09
申请号：US10131448
申请日：2002-04-22
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K3144
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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