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公开(公告)号:US11931713B2
公开(公告)日:2024-03-19
申请号:US15102209
申请日:2014-11-26
IPC分类号: B01J19/00 , C12Q1/68 , C12Q1/6874
CPC分类号: B01J19/0046 , C12Q1/68 , C12Q1/6874 , B01J2219/00529 , B01J2219/00596 , B01J2219/00722 , C12Q1/68 , C12Q2563/185
摘要: A data storage medium is disclosed comprising a solid support matrix including an optional stabilising reagent or reagents in a dry form, for use as a support for artificially synthesised oligonucleotide sequences encoded with data. Preferably the matrix is fibrous (for example cellulose, or glass, fibres) formed into a support of sufficient strength to hold the oligonucleotide sequences. The stabilising reagents are preferably a combination of a weak base, and a chelating agent, optionally, uric acid or a urate salt, and optionally an anionic surfactant.
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公开(公告)号:US20230417638A1
公开(公告)日:2023-12-28
申请号:US18248806
申请日:2021-10-20
发明人: Klas Marteleur , Devina Divekar
CPC分类号: G01N1/286 , A01N1/0252
摘要: The present invention relates to a sample processing bag (10) for use in a tissue disaggregation apparatus (200) for disaggregation of tissue therein. A clamp assembly 60 comprising a base support (70) and a clamp mechanism (72) is configured to retain the sample processing bag (10) adjacent to the base support (70) during a tissue disaggregation operation such that action of the tissue disaggregation apparatus 200 acts on the sample processing bag (10) to disaggregate any tissue therein.
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公开(公告)号:US11754563B2
公开(公告)日:2023-09-12
申请号:US14548383
申请日:2014-11-20
发明人: Bing Li , Brian Christopher Bales , David Roger Moore , Jason Michael Nichols , Cathryn Ellen Olsen , William Christopher Alberts , Frank John Mondello
IPC分类号: G01N33/543 , G01N33/548
CPC分类号: G01N33/54388 , G01N33/548 , G01N33/54353
摘要: A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).
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公开(公告)号:US11001868B2
公开(公告)日:2021-05-11
申请号:US15631510
申请日:2017-08-11
发明人: Erik Leeming Kvam , John Richard Nelson , Wei Gao
摘要: Methods for in vitro transcription and translation using a double-stranded concatemeric DNA in a eukaryotic cell-free expression system are provided. The method includes the steps of (a) contacting a double-stranded concatemeric DNA with a eukaryotic cell-free expression system, and (b) expressing a protein in vitro from the double-stranded concatemeric DNA in the eukaryotic cell-free expression system. The double-stranded concatemeric DNA includes a plurality of tandem repeat sequences. The plurality of tandem repeat sequences includes an expression sequence including a promoter, a cap-independent translation element (CITE), and an open reading frame. A final concentration of the double-stranded concatemeric DNA in the eukaryotic cell-free expression system is in a range from about 0.1 ng/μL to about 35 ng/μL. A RCA product DNA may be used as the double stranded concatemer DNA for the methods.
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公开(公告)号:US10968478B2
公开(公告)日:2021-04-06
申请号:US15533714
申请日:2015-12-18
IPC分类号: C12Q1/68 , C12Q1/686 , C07H1/00 , C07H21/02 , C12Q1/6806 , C12Q1/6848
摘要: The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a polar aprotic solvent; a serum albumin, and a polyol.
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公开(公告)号:US10822645B1
公开(公告)日:2020-11-03
申请号:US15534711
申请日:2015-12-18
IPC分类号: C12Q1/68 , C12Q1/6848 , C12Q1/686
摘要: The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a polyol, a serum albumin, a non-ionic surfactant and a reducing agent.
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公开(公告)号:US20240181398A1
公开(公告)日:2024-06-06
申请号:US18551012
申请日:2022-03-17
IPC分类号: B01D63/08 , B01D69/02 , B01D69/12 , G01N33/543
CPC分类号: B01D63/088 , B01D63/087 , B01D69/02 , B01D69/1216 , G01N33/54388 , B01D2325/021 , B01D2325/02834
摘要: The present invention provides for simple and rapid filtering of biological samples, whereby a sample can be analyzed in the same device or a different device. In one preferred example, a membrane filter 12 that is particularly useful for the filtration of samples comprising viruses along with other biological materials that need be separated from the viruses is used. A lateral flow device 10 incorporating a filter membrane/membrane filter 12 is also disclosed.
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公开(公告)号:US11696969B2
公开(公告)日:2023-07-11
申请号:US16078749
申请日:2017-02-28
发明人: Peter James Tatnell
CPC分类号: A61L2/28 , A61L2/206 , G01N31/226 , A61L2202/23 , A61L2202/24
摘要: The present invention provides an indicator useful in confirming successful sterilisation and/or nucleic acid decontamination by ethylene oxide (EtO) treatment. The invention also provides a label comprising said indicator and methods for use of the indicator and label in a method of EtO treatment.
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公开(公告)号:USD988538S1
公开(公告)日:2023-06-06
申请号:US29778672
申请日:2021-04-14
设计人: Devina Divekar , Thiyaga Rajan
摘要: FIG. 1 is a front, left side perspective view of a tissue processing bag;
FIG. 2 is a front, right perspective view thereof;
FIG. 3 is a front view thereof (the rear view is a mirror image of the front view);
FIG. 4 is a top view thereof (the bottom view is a mirror image of the top view);
FIG. 5 is a right view thereof; and,
FIG. 6 is a left view thereof.
The broken dot-dash lines in the drawings depict symbolic break lines that form no part of the claimed design.-
公开(公告)号:US10858694B2
公开(公告)日:2020-12-08
申请号:US15534578
申请日:2015-12-18
IPC分类号: C12Q1/6844 , C12Q1/6806
摘要: The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a) a polar aprotic solvent; b) a serum albumin; and optionally c) a non-ionic surfactant and/or a betaine.
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