公开(公告)号：US20090002700A1

公开(公告)日：2009-01-01

申请号：US11770945

申请日：2007-06-29

申请人： Liming Wang ,  Grace Credo

发明人： Liming Wang ,  Grace Credo

IPC分类号： G01N21/01 ,  G01J3/44

CPC分类号： G01N21/658 ,  G01N2021/651

摘要： Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.

摘要翻译： 装置，使用该装置的方法，包括装置的系统的装置包括具有样品容器（孔）的样品板，其中样品板和/或样品容器的至少一部分表面涂覆有光学反射材料。 光学反射材料提供增强的激发信号强度和增强的拉曼信号强度。 这种增强提供改进的总信号检测能力，以及改进聚焦算法的方法。

公开(公告)号：US08070928B2

公开(公告)日：2011-12-06

申请号：US11967657

申请日：2007-12-31

申请人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

发明人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

IPC分类号： G01N27/26 ,  B01D27/02

CPC分类号： C12N15/1006

摘要： Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.

摘要翻译： 本发明的实施方案提供了使用电场从溶液中提取核酸分子的装置和方法。 本发明的实施例的结构和方法适合于并入微纳米流体装置，例如片上实验室装置和微总体分析系统。

公开(公告)号：US07816665B2

公开(公告)日：2010-10-19

申请号：US10502872

申请日：2003-02-27

申请人： Christopher B. Gorman ,  Richard Lloyd Carroll ,  Grace Credo

发明人： Christopher B. Gorman ,  Richard Lloyd Carroll ,  Grace Credo

IPC分类号： H01L29/06

CPC分类号： G11C13/025 ,  B82Y10/00 ,  B82Y30/00 ,  G11C11/39 ,  G11C13/0014 ,  G11C2211/5614 ,  G11C2213/81 ,  H01L51/0077 ,  H01L51/0595 ,  Y10S977/702 ,  Y10S977/703 ,  Y10S977/705 ,  Y10S977/72 ,  Y10S977/755

摘要： A negative differential resistance (NDR) device, and methods of making and using the NDR device. The NDR device includes a substrate comprising a conductor material or a semi-conductor material and a self-assembled monolayer (SAM) that includes a first electroactive moiety and a spacer moiety disposed on the substrate that defines a barrier between the electroactive moiety and the substrate, wherein the NDR device exhibits negative differential resistance in the presence of a varying applied voltage. Also provided are NDR in multilayers in which the peak to valley ratio of the NDR response can be controlled by the number of layers; modulation of NDR using binding groups to one of the electrical contacts or to the electroactive moiety itself; and NDR devices that display multiple peaks in the current-voltage curve that contain electroactive moieties that have multiple low potential electrochemical oxidations and/or reductions.

摘要翻译： 负差分电阻（NDR）器件，以及制造和使用NDR器件的方法。 NDR器件包括包括导体材料或半导体材料的衬底和自组装单层（SAM），其包括设置在衬底上的第一电活性部分和限定电活性部分和衬底之间的屏障的间隔部分 ，其中NDR器件在存在变化的施加电压的情况下表现出负的差分电阻。 还提供了多层的NDR，其中NDR响应的峰谷比可以由层数控制; 使用结合基团调节NDR至电接触之一或电活性部分本身; 以及在电流 - 电压曲线中显示多个具有多个低电位电化学氧化和/或还原的电活性部分的多个峰的NDR器件。

公开(公告)号：US20090166205A1

公开(公告)日：2009-07-02

申请号：US11967657

申请日：2007-12-31

申请人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

发明人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

IPC分类号： B01D57/02 ,  C02F1/469

CPC分类号： C12N15/1006

摘要： Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.

摘要翻译： 本发明的实施方案提供了使用电场从溶液中提取核酸分子的装置和方法。 本发明的实施例的结构和方法适合于并入微纳米流体装置，例如片上实验室装置和微总体分析系统。

公开(公告)号：US08273242B2

公开(公告)日：2012-09-25

申请号：US13273934

申请日：2011-10-14

申请人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

发明人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

IPC分类号： G01N27/327 ,  G01N27/26 ,  G01N27/447 ,  C12N11/02 ,  C12Q1/00

CPC分类号： C12N15/1006

摘要： Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.

摘要翻译： 本发明的实施方案提供了使用电场从溶液中提取核酸分子的装置和方法。 本发明的实施例的结构和方法适合于并入微纳米流体装置，例如片上实验室装置和微总体分析系统。

公开(公告)号：US08194244B2

公开(公告)日：2012-06-05

申请号：US11770945

申请日：2007-06-29

申请人： Liming Wang ,  Grace Credo

发明人： Liming Wang ,  Grace Credo

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  G01N2021/651

摘要： Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.

摘要翻译： 装置，使用该装置的方法，包括装置的系统的装置包括具有样品容器（孔）的样品板，其中样品板和/或样品容器的至少一部分表面涂覆有光学反射材料。 光学反射材料提供增强的激发信号强度和增强的拉曼信号强度。 这种增强提供改进的总信号检测能力，以及改进聚焦算法的方法。

公开(公告)号：US20060157648A1

公开(公告)日：2006-07-20

申请号：US11288590

申请日：2005-11-29

申请人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

发明人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

IPC分类号： H01J49/00

CPC分类号： H01J49/0418 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/12 ,  G01N1/22

摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1 or O—SiR1,R2,R3 wherein R1,R2, and R3 are selected from the group consisting C1 to C6 straight, cyclic, or branched alkyl, aryl, or alkoxy group, a hydroxyl group, or a siloxane group, and R6 may be a C1 to C36 straight, cyclic, or branched alkyl (e.g., C18, cyanopropyl), aryl, or alkoxy group, where the groups of R6 are unsubstituted or substituted with one or more moieties such as halogen, cyano, amino, diol, nitro, ether, carbonyl, epoxide, sulfonyl, cation exchanger, anion exchanger, carbamate, amide, urea, peptide, protein, carbohydrate, and nucleic acid functionalities. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.

摘要翻译： 本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。 涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基 或-OR 1或O-SiR 1，R 2，R 3，其中R 1 R 2，R 3和R 3选自C 1至C 6 - ， - 直链，环状或支链烷基，芳基或烷氧基，羟基或硅氧烷基，R 6可以是C 1〜 36个直链，环状或支链烷基（例如C 18，氰基丙基），芳基或烷氧基，其中R 6基团是未取代的或 被一个或多个部分取代，例如卤素，氰基，氨基，二醇，硝基，醚，羰基，环氧化物，磺酰基，阳离子交换剂，阴离子交换剂，氨基甲酸酯，酰胺，脲，肽，蛋白质，碳水化合物和核酸功能。 字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

公开(公告)号：US20120031758A1

公开(公告)日：2012-02-09

申请号：US13273934

申请日：2011-10-14

申请人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

发明人： Steven A. Sundberg ,  Xing Su ,  Grace Credo

IPC分类号： C25B7/00 ,  G01N27/447

CPC分类号： C12N15/1006

摘要： Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.

摘要翻译： 本发明的实施方案提供了使用电场从溶液中提取核酸分子的装置和方法。 本发明的实施例的结构和方法适合于并入微纳米流体装置，例如片上实验室装置和微总体分析系统。

公开(公告)号：US20120274936A1

公开(公告)日：2012-11-01

申请号：US13485298

申请日：2012-05-31

申请人： Liming Wang ,  Grace Credo

发明人： Liming Wang ,  Grace Credo

IPC分类号： G01J3/44 ,  G01N21/01

CPC分类号： G01N21/658 ,  G01N2021/651

摘要： Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.

摘要翻译： 装置，使用该装置的方法，包括装置的系统的装置包括具有样品容器（孔）的样品板，其中样品板和/或样品容器的至少一部分表面涂覆有光学反射材料。 光学反射材料提供增强的激发信号强度和增强的拉曼信号强度。 这种增强提供改进的总信号检测能力，以及改进聚焦算法的方法。

公开(公告)号：US20080073512A1

公开(公告)日：2008-03-27

申请号：US11829170

申请日：2007-07-27

申请人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

发明人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

IPC分类号： C01B33/113 ,  C07F7/02 ,  H01J49/16

CPC分类号： B01L3/5085 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/12 ,  H01J49/0418

摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1, or O—SiR1, R2, R3 wherein R1, R2, and R3 are selected from the group consisting of alkyl, alkenyl, alkynyl, aromatic, amino alkyl, amino alkenyl, amino alkynyl, pyridinyl, pyrridonyl, and carbonyl, alcohol and carboxylic acid derivatives thereof having one to twenty five atoms, and hydroxyl, amino, amide, carboxyl, ester, carbonyl, sulfhydryl, sulfonyl, phosphoral, bromo, iodo, chloro and fluoro derivatives. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.

摘要翻译： 本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。 涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基 或-OR 1，或O-SiR 1，R 2，R 3，其中R 1， R 1，R 2，R 3和R 3选自烷基，烯基，炔基，芳族，氨基烷基，氨基烯基，氨基炔基， 吡啶基，吡咯基和羰基，具有一至二十五个原子的醇和羧酸衍生物，以及羟基，氨基，酰胺，羧基，酯，羰基，巯基，磺酰基，磷酰基，溴，碘，氯和氟衍生物。 字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。