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    Methods, compositions and devices for performing ionization desorption on silicon derivatives
    1.
    发明申请
    Methods, compositions and devices for performing ionization desorption on silicon derivatives 审中-公开
    用于在硅衍生物上进行电离解吸的方法，组合物和装置

    公开(公告)号：US20060157648A1

    公开(公告)日：2006-07-20

    申请号：US11288590

    申请日：2005-11-29

    申请人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

    发明人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0418 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/12 ,  G01N1/22

    摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1 or O—SiR1,R2,R3 wherein R1,R2, and R3 are selected from the group consisting C1 to C6 straight, cyclic, or branched alkyl, aryl, or alkoxy group, a hydroxyl group, or a siloxane group, and R6 may be a C1 to C36 straight, cyclic, or branched alkyl (e.g., C18, cyanopropyl), aryl, or alkoxy group, where the groups of R6 are unsubstituted or substituted with one or more moieties such as halogen, cyano, amino, diol, nitro, ether, carbonyl, epoxide, sulfonyl, cation exchanger, anion exchanger, carbamate, amide, urea, peptide, protein, carbohydrate, and nucleic acid functionalities. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.

    摘要翻译： 本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。 涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基 或-OR 1或O-SiR 1，R 2，R 3，其中R 1 R 2，R 3和R 3选自C 1至C 6 - ， - 直链，环状或支链烷基，芳基或烷氧基，羟基或硅氧烷基，R 6可以是C 1〜 36个直链，环状或支链烷基（例如C 18，氰基丙基），芳基或烷氧基，其中R 6基团是未取代的或 被一个或多个部分取代，例如卤素，氰基，氨基，二醇，硝基，醚，羰基，环氧化物，磺酰基，阳离子交换剂，阴离子交换剂，氨基甲酸酯，酰胺，脲，肽，蛋白质，碳水化合物和核酸功能。 字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

    METHODS, COMPOSITIONS AND DEVICES FOR PERFORMING IONIZATION DESORPTION ON SILICON DERIVATIVES
    2.
    发明申请
    METHODS, COMPOSITIONS AND DEVICES FOR PERFORMING IONIZATION DESORPTION ON SILICON DERIVATIVES 审中-公开
    用于对硅衍生物进行离子沉淀的方法，组合物和装置

    公开(公告)号：US20080073512A1

    公开(公告)日：2008-03-27

    申请号：US11829170

    申请日：2007-07-27

    申请人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

    发明人： Gary Siuzdak ,  Eden Go ,  Zhouxin Shen ,  Bruce Compton ,  Edouard Bouvier ,  Grace Credo

    IPC分类号： C01B33/113 ,  C07F7/02 ,  H01J49/16

    CPC分类号： B01L3/5085 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/12 ,  H01J49/0418

    摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1, or O—SiR1, R2, R3 wherein R1, R2, and R3 are selected from the group consisting of alkyl, alkenyl, alkynyl, aromatic, amino alkyl, amino alkenyl, amino alkynyl, pyridinyl, pyrridonyl, and carbonyl, alcohol and carboxylic acid derivatives thereof having one to twenty five atoms, and hydroxyl, amino, amide, carboxyl, ester, carbonyl, sulfhydryl, sulfonyl, phosphoral, bromo, iodo, chloro and fluoro derivatives. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.

    摘要翻译： 本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。 涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基 或-OR 1，或O-SiR 1，R 2，R 3，其中R 1， R 1，R 2，R 3和R 3选自烷基，烯基，炔基，芳族，氨基烷基，氨基烯基，氨基炔基， 吡啶基，吡咯基和羰基，具有一至二十五个原子的醇和羧酸衍生物，以及羟基，氨基，酰胺，羧基，酯，羰基，巯基，磺酰基，磷酰基，溴，碘，氯和氟衍生物。 字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

    Multidimensional liquid chromatography/spectrometry
    4.
    发明申请
    Multidimensional liquid chromatography/spectrometry 审中-公开
    多维液相色谱/光谱法

    公开(公告)号：US20060157647A1

    公开(公告)日：2006-07-20

    申请号：US11036160

    申请日：2005-01-18

    申请人： Gary Siuzdak ,  Zhouxin Shen

    发明人： Gary Siuzdak ,  Zhouxin Shen

    IPC分类号： H01J49/04 ,  G01N30/72 ,  G01N30/62

    CPC分类号： G01N30/463

    摘要： A liquid chromatography configuration providing at least three dimensions of separation coupled with spectrometry greatly improves the ability to detect ions present in samples, including complex biological samples such as blood. Liquid chromatography columns in one embodiment are connected with an in-line trapping column the alternately communicates with the second and third liquid chromatography columns. The liquid chromatography columns are operably connected either to a mass spectrometer (MS) or a nuclear magnetic resonance (NMR) spectrometer. The improved dynamic range of detection allows a method of detecting molecular components present in complex biological samples that serve as biomarkers for a disease state, such as sepsis.

    摘要翻译： 提供至少三维分离结合光谱法的液相色谱配置大大提高了检测样品中存在的离子的能力，包括复杂的生物样品如血液。 一个实施方案中的液相色谱柱与在线捕集柱连接，其与第二和第三液相色谱柱交替连通。 液相色谱柱可操作地连接到质谱仪（MS）或核磁共振（NMR）光谱仪上。 改进的动态检测范围允许检测作为疾病状态如败血症的生物标志物的复杂生物样品中存在的分子成分的方法。

    NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY
    8.
    发明申请
    NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY 审中-公开

    公开(公告)号：US20080128608A1

    公开(公告)日：2008-06-05

    申请号：US11852863

    申请日：2007-09-10

    申请人： Trent Northen ,  Gary Siuzdak ,  Anders Nordstrom

    发明人： Trent Northen ,  Gary Siuzdak ,  Anders Nordstrom

    IPC分类号： H01J49/00 ,  B32B3/00 ,  B32B3/26

    CPC分类号： H01J49/0413 ,  Y10T428/24479 ,  Y10T428/249953

    摘要： A substrate for use in providing an ionized target comprising a structured substrate has a plurality of recesses, at least a portion of the plurality of recesses containing an initiator, the substrate being capable of having a target loaded on it. In one methods, irradiation of the substrate can cause the initiator to restructure, releasing it from the recesses and thereby desorbing and ionizing the target. The target so desorbed and ionized can be detected by mass analyzers. The mass of the targets at a given point on the surface can be recorded to provide a spatial mapping of the targets on the surface.

    摘要翻译： 用于提供包括结构化衬底的电离靶的衬底具有多个凹部，所述多个凹部的至少一部分包含引发剂，所述衬底能够加载靶。 在一种方法中，基材的照射可引起引发剂重结构，将其从凹部中释放出来，从而使靶解离和电离。 通过质谱仪可以检测到如此解吸和离子化的目标物。 可以记录表面上给定点处的目标质量以提供目标在表面上的空间映射。

    DIAGNOSIS OF SEPSIS
    9.
    发明申请
    DIAGNOSIS OF SEPSIS 审中-公开
    SEPSIS诊断

    公开(公告)号：US20090104605A1

    公开(公告)日：2009-04-23

    申请号：US12098398

    申请日：2008-04-04

    申请人： Gary Siuzdak ,  William A. Nussbaumer ,  Craig C. Whiteford ,  Richard L. Moore

    发明人： Gary Siuzdak ,  William A. Nussbaumer ,  Craig C. Whiteford ,  Richard L. Moore

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  G06G7/60

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/26 ,  G16B25/00 ,  Y02A90/26

    摘要： Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods and apparatus for diagnosing sepsis in a subject are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

    摘要翻译： 提供了用于预测罹患败血症风险的受试者脓毒症发展的方法和装置。 评估受试者生物标志物特征。 如果这些特征满足特定的值集合，主体可能会发展为败血症。 提供了一种用于预测脓毒症发展阶段罹患脓毒症发展阶段的方法和装置。 评估对象的生物标志物轮廓中的多个特征。 如果这些特征值满足特定的值集合，受试者可能具有脓毒症的阶段。 提供了用于诊断受试者败血症的方法和装置。 评估对象的生物标志物轮廓中的多个特征。 当多个特征满足特定值集合时，受试者可能发展为败血症。