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公开(公告)号：US07868037B2
公开(公告)日：2011-01-11
申请号：US11331180
申请日：2006-01-13
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Jan Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Allan Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Jan Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Allan Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D403/12 , C07D209/14 , C07D209/42 , C07D401/12 , C07D403/10 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US08013006B2
公开(公告)日：2011-09-06
申请号：US11180961
申请日：2005-07-14
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC分类号： A01N43/38 , A61K31/405 , C07D209/04
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20120009142A1
公开(公告)日：2012-01-12
申请号：US13158653
申请日：2011-06-13
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC分类号： A61K38/20 , C07D401/10 , C07D409/06 , C07D403/10 , A61P31/14 , A61K31/454 , A61K31/4178 , A61K38/21 , A61K31/7056 , C07D209/40 , A61K31/404
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US20100305100A1
公开(公告)日：2010-12-02
申请号：US12828597
申请日：2010-07-01
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/55 , C07D209/04 , C07D417/06 , C07D405/12 , C07D271/10 , C07D403/04 , C07D263/30 , C07D401/12 , C07D239/10 , C07D215/00 , C07D223/16 , A61K31/405 , A61K31/40 , A61K31/4155 , A61K31/4245 , A61K31/427 , A61K31/42 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61P31/14 , A61P31/12
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US07781478B2
公开(公告)日：2010-08-24
申请号：US11653450
申请日：2007-01-16
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US07973069B2
公开(公告)日：2011-07-05
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100292187A1
公开(公告)日：2010-11-18
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/675 , A61K31/541 , A61K31/53 , A61K31/497 , A61K31/506 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4155 , A61K31/407 , A61K31/404 , C07D417/12 , C07D413/12 , C07D401/12 , C07D413/04 , C07D417/10 , C07D413/10 , C07F9/572 , C07D491/14 , C07D403/10 , C07D209/14 , C07D403/12 , C07D407/12 , C07D417/04 , C07D403/04 , C07D401/04 , A61P31/12
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US20150080362A1
公开(公告)日：2015-03-19
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D515/04 , A61K31/4412 , C07D401/10 , A61K45/06 , A61K31/5377 , A61K31/4439 , C07D487/08 , A61K31/5383 , C07D213/80 , A61K31/4427
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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公开(公告)号：US09650395B2
公开(公告)日：2017-05-16
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： A61K31/4427 , A61K31/4412 , A61K45/06 , A61K31/5383 , C07D515/04 , A61K31/5377 , A61K31/4439 , C07D213/80 , C07D401/10 , C07D487/08 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/496
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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