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    Peptides for inhibiting the HPV-E6 oncoprotein
    1.
    发明授权
    Peptides for inhibiting the HPV-E6 oncoprotein 失效
    用于抑制HPV-E6癌蛋白的肽

    公开(公告)号：US08598126B2

    公开(公告)日：2013-12-03

    申请号：US12936679

    申请日：2009-04-07

    申请人： Felix Hoppe-Seyler ,  Karin Hoppe-Seyler ,  Susanne Kintscher

    发明人： Felix Hoppe-Seyler ,  Karin Hoppe-Seyler ,  Susanne Kintscher

    IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K38/04 ,  C12N15/00 ,  C12N1/00 ,  C12N5/04 ,  C12N5/10 ,  C12N5/02

    CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/41 ,  C07K2319/42 ,  C07K2319/43 ,  G01N33/56983 ,  G01N2333/025 ,  G01N2500/00

    摘要： The present invention is concerned with means and methods for diagnosing or treating HPV associated neoplasia or tumors. Specifically, it relates to a peptide comprising an amino acid sequence motif as shown in SEQ ID No: 1. Moreover, contemplated by the present invention are fusion polypeptides, polynucleotides, vectors and host cells based on said peptide. Furthermore, the peptides, fusion polypeptides, polynucleotides, and vectors are suitable as pharmaceutical compositions for treating HPV associated neoplasia or tumors. The peptides and fusion polypeptides are also suitable as diagnostic compositions for diagnosing HPV associated neoplasia or tumors. The present invention also refers to a method of identifying a compound capable of binding to the HPV E6 protein. Finally, a kit is provided for carrying out the aforementioned diagnosis or compound identification.

    摘要翻译： 本发明涉及用于诊断或治疗HPV相关瘤形成或肿瘤的方法和方法。 具体地，本发明涉及包含SEQ ID No：1所示的氨基酸序列基序的肽。此外，本发明考虑的是基于所述肽的融合多肽，多核苷酸，载体和宿主细胞。 此外，肽，融合多肽，多核苷酸和载体适合作为用于治疗HPV相关瘤形成或肿瘤的药物组合物。 肽和融合多肽也适用于诊断HPV相关瘤形成或肿瘤的诊断组合物。 本发明还涉及鉴定能够结合HPV E6蛋白的化合物的方法。 最后，提供了用于进行上述诊断或化合物鉴定的试剂盒。

    PEPTIDES FOR INHIBITING THE HPV-E6 ONCOPROTEIN
    3.
    发明申请
    PEPTIDES FOR INHIBITING THE HPV-E6 ONCOPROTEIN 失效
    抑制HPV-E6蛋白激酶的肽

    公开(公告)号：US20110201560A1

    公开(公告)日：2011-08-18

    申请号：US12936679

    申请日：2009-04-07

    申请人： Felix Hoppe-Seyler ,  Karin Hoppe-Seyler ,  Susanne Kintscher

    发明人： Felix Hoppe-Seyler ,  Karin Hoppe-Seyler ,  Susanne Kintscher

    IPC分类号： A61K38/08 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K19/00 ,  G01N33/68 ,  A61K31/7088 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C12N5/10 ,  A61P35/00

    CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/41 ,  C07K2319/42 ,  C07K2319/43 ,  G01N33/56983 ,  G01N2333/025 ,  G01N2500/00

    摘要： The present invention is concerned with means and methods for diagnosing or treating HPV associated neoplasia or tumors. Specifically, it relates to a peptide comprising an amino acid sequence motif as shown in SEQ ID No: 1. Moreover, contemplated by the present invention are fusion polypeptides, polynucleotides, vectors and host cells based on said peptide. Furthermore, the peptides, fusion polypeptides, polynucleotides, and vectors are suitable as pharmaceutical compositions for treating HPV associated neoplasia or tumors. The peptides and fusion polypeptides are also suitable as diagnostic compositions for diagnosing HPV associated neoplasia or tumors. The present invention also refers to a method of identifying a compound capable of binding to the HPV E6 protein. Finally, a kit is provided for carrying out the aforementioned diagnosis or compound identification.

    摘要翻译： 本发明涉及用于诊断或治疗HPV相关瘤形成或肿瘤的方法和方法。 具体地，本发明涉及包含SEQ ID No：1所示的氨基酸序列基序的肽。此外，本发明考虑的是基于所述肽的融合多肽，多核苷酸，载体和宿主细胞。 此外，肽，融合多肽，多核苷酸和载体适合作为用于治疗HPV相关瘤形成或肿瘤的药物组合物。 肽和融合多肽也适用于诊断HPV相关瘤形成或肿瘤的诊断组合物。 本发明还涉及鉴定能够结合HPV E6蛋白的化合物的方法。 最后，提供了用于进行上述诊断或化合物鉴定的试剂盒。

    Soft Material Separator with Fill-Level-Dependent Adjustment of Speed, and Method for Operating Such a Soft Material Separator
    4.
    发明申请
    Soft Material Separator with Fill-Level-Dependent Adjustment of Speed, and Method for Operating Such a Soft Material Separator 有权

    公开(公告)号：US20210037837A1

    公开(公告)日：2021-02-11

    申请号：US16965637

    申请日：2018-10-30

    申请人： Modernpack Hoppe GmbH

    发明人： Hoppe GÜNTHER

    IPC分类号： A22C17/04 ,  B30B9/24

    摘要： A soft material separator (1) has a perforated drum (2) A pressing band (3) is guided along a circumferential section (19) of the perforated drum (2) and can be operated together with the perforated drum (2). A feed zone (7), from which a substance mixture (14) consisting of substance components (12, 13) of different consistencies is drawn in between the perforated drum (2) and the pressing band (3) to separate the substance components (12, 13). For optimization in terms of wear and energy consumption without any or without significant losses in effectiveness of the device, a detection system (9) is provided to quantitatively determine the fill level of the feed zone (7), and a control apparatus (10) which is connected to the detection system (9) is provided to adjust the speed of the perforated drum (2) and of the pressing band (3) depending on the fill level.

    unknown
    5.
    发明申请
    unknown 审中-公开

    公开(公告)号：US20190218819A1

    公开(公告)日：2019-07-18

    申请号：US16224349

    申请日：2018-12-18

    申请人： HOPPE AG

    发明人： Oliver Schuberth

    IPC分类号： E05B13/00 ,  E05B15/02

    CPC分类号： E05B13/002 ,  E05B13/004 ,  E05B15/0053 ,  E05B15/02 ,  E05B35/008

    摘要： The invention relates to an actuating handle (100) for a door with an escutcheon (104) and a handle (102) for actuating a locking device arranged in the door. The handle (102) for actuating the locking device is mounted in the escutcheon (104) rotatably about a first axis of rotation. The actuating handle (100) moreover has a blocking device (106), having a release position in which a rotation of the handle (102) about the first axis of rotation is released, and a blocking position in which a rotation of the handle (102) about the first axis of rotation is blocked by the blocking device (106). The actuating handle (100) moreover has an actuating mechanism (112) for the blocking device (106). According to the invention, it is provided that the actuating mechanism (112) has a sliding element (108) which is displaceable along a circle segment centered around the first axis of rotation, wherein a displacement of the sliding element (108) along the circle segment brings about an actuation of the blocking device (106).

    System and method for installing authentication credentials on a network device
    10.
    发明授权
    System and method for installing authentication credentials on a network device 有权
    用于在网络设备上安装认证证书的系统和方法

    公开(公告)号：US09218469B2

    公开(公告)日：2015-12-22

    申请号：US12205685

    申请日：2008-09-05

    申请人： Sally Blue Hoppe ,  Jim Harritt ,  Matt Torres

    发明人： Sally Blue Hoppe ,  Jim Harritt ,  Matt Torres

    IPC分类号： G06F17/30 ,  G06F21/31 ,  H04L29/06

    CPC分类号： G06F21/31 ,  H04L63/06 ,  H04L63/08

    摘要： A method for installing authentication credentials on a network device. An intermediary computing device (e.g., client computer) downloads an application for installing the authentication credentials from a secure website. The application on the intermediary computing device requests authentication credentials from a Network Access Control (NAC) credential service. The application passes the authentication credentials received from the NAC credential service through the intermediary computing device to an endpoint (e.g., video conferencing device). The application installs the authentication credentials on the endpoint.

    摘要翻译： 一种在网络设备上安装认证凭证的方法。 中间计算设备（例如，客户端计算机）从安全网站下载用于安装认证证书的应用。 中介计算设备上的应用程序从网络访问控制（NAC）凭证服务请求认证凭证。 应用程序将通过中间计算设备从NAC凭证服务接收的认证凭证传递到端点（例如，视频会议设备）。 该应用程序将在端点上安装身份验证凭据。