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1.发明授权Delta-5 desaturases and their use in making polyunsaturated fatty acids 有权Delta-5去饱和酶及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08957280B2
公开(公告)日：2015-02-17
申请号：US12111228
申请日：2008-04-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N9/0071 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/115 , C12N9/0083 , C12N15/8247 , C12Y114/19
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-5 desaturases in plants are disclosed.
Abstract translation: 公开了分离的核酸片段和包含编码Δ-5去饱和酶的片段的重组构建物以及在植物中使用这些δ-5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US08518674B2
公开(公告)日：2013-08-27
申请号：US12893469
申请日：2010-09-29
Applicant: Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
CPC classification number: C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
Abstract translation: 描述了能够在总油馏分中产生大于25％二十碳五烯酸（EPA，ω-3多不饱和脂肪酸）的含油酵母解脂耶氏酵母解脂耶氏酵母菌的工程菌株。 这些菌株包括表达异源去饱和酶，延伸酶和酰基转移酶的各种嵌合基因，并且任选地包含各种天然去饱和酶和酰基转移酶敲除，以使EPA能够合成和高度积累。 要求生产宿主细胞，以及在所述宿主细胞内生产EPA的方法。
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公开(公告)号：US08420892B2
公开(公告)日：2013-04-16
申请号：US12725482
申请日：2010-03-17
Applicant: Howard Glenn Damude , Brian McGonigle , Quinn Qun Zhu , Zhixiong Xue
Inventor： Howard Glenn Damude , Brian McGonigle , Quinn Qun Zhu , Zhixiong Xue
CPC classification number: C12N15/8247 , C11B1/025 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
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4.发明授权Use of a seed specific promoter to drive ODP1 expression in cruciferous oilseed plants to increase oil content while maintaining normal germination 有权使用种子特异性启动子在十字花科植物中驱动ODP1表达以增加油含量，同时保持正常发芽公开(公告)号：US08404926B2
公开(公告)日：2013-03-26
申请号：US12752175
申请日：2010-04-01
Applicant: Knut Meyer , Howard Glenn Damude , John D. Everard , Kevin G. Ripp , Kevin L. Stecca
Inventor： Knut Meyer , Howard Glenn Damude , John D. Everard , Kevin G. Ripp , Kevin L. Stecca
CPC classification number: C12N15/8247 , C12N15/8201
Abstract: A recombinant DNA construct comprising a polynucleotide encoding an ODP1 polypeptide operably linked to a sucrose synthase 2 promoter where this construct can be used to increase oil content in the seeds of a cruciferous oilseed plant while maintaining normal germination is disclosed. A method for increasing oil content in the seeds of a cruciferous oilseed plant while maintaining normal germination using this construct is also disclosed.
Abstract translation: 公开了一种重组DNA构建体，其包含编码与蔗糖合酶2启动子可操作地连接的ODP1多肽的多核苷酸，其中该构建体可用于增加十字花科油籽植物的种子中的油含量，同时保持正常发芽。 还公开了一种在使用该构建体保持正常发芽的同时增加十字花科油籽植物的种子中的油含量的方法。
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5.发明授权公开(公告)号：US08273957B2
公开(公告)日：2012-09-25
申请号：US12420345
申请日：2009-04-08
Applicant: Howard Glenn Damude , Narendra S. Yadav
Inventor： Howard Glenn Damude , Narendra S. Yadav
IPC: A01H5/00
CPC classification number: C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
Abstract: The present invention relates to fungal Δ-15 fatty acid desaturases that are able to catalyze the conversion of linoleic acid (18:2, LA) to alpha-linolenic acid (18:3, ALA). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host plants and microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific omega-3 and omega-6 fatty acids by over-expression of the Δ-15 fatty acid desaturases are also described herein.
Abstract translation: 本发明涉及能够催化亚油酸（18:2，LA）转化为α-亚麻酸（18:3，ALA）的真菌和Dgr-15脂肪酸去饱和酶。 描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主植物和微生物。 本文还描述了通过过量表达＆Dgr-15脂肪酸去饱和酶来增加特定ω-3和ω-6脂肪酸的产生的方法。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08084074B2
公开(公告)日：2011-12-27
申请号：US11673843
申请日：2007-02-12
Applicant: Anthony J. Kinney , Edgar Benjamin Cahoon , Howard Glenn Damude , William D. Hitz , Zhan-Bin Liu , Charles W. Kolar, Jr.
Inventor： Anthony J. Kinney , Edgar Benjamin Cahoon , Howard Glenn Damude , William D. Hitz , Zhan-Bin Liu , Charles W. Kolar, Jr.
IPC: A23D9/00
CPC classification number: A23K20/158 , A23L2/52 , A23L33/115 , A23L33/12
Abstract: Oilseed plants which have been transformed to produce at least 8.0% arachidonic acid (ARA) as well as uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Abstract translation: 已经转化生产至少8.0％花生四烯酸（ARA）的油籽植物以及在各种食品和饲料应用中从这种转化植物获得的油和种子的用途被描述。
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公开(公告)号：US08013215B2
公开(公告)日：2011-09-06
申请号：US12029557
申请日：2008-02-12
Applicant: Howard Glenn Damude , Anthony J. Kinney
Inventor： Howard Glenn Damude , Anthony J. Kinney
CPC classification number: C12N15/8247 , A23D9/00 , A23K10/30 , A23K20/163 , A23K50/80 , A23L33/12 , C12N9/0083 , C12N9/1029 , Y02A40/818
Abstract: Oilseed plants which have been transformed to produce arachidonic acid, recombinant constructs used in such transformations, methods for producing arachidonic acid in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Abstract translation: 已经转化生产花生四烯酸的油籽植物，用于这种转化的重组构建体，植物中花生四烯酸的生产方法，并描述了在各种食品和饲料应用中从这些转化植物获得的油和种子的用途。
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8.发明授权公开(公告)号：US07943365B2
公开(公告)日：2011-05-17
申请号：US12111237
申请日：2008-04-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N9/0071 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/115 , C12N9/0083 , C12N15/8247 , C12Y114/19
Abstract: The present invention relates to Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ5 desaturases in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二焦γ-亚麻酸（DGLA; 20：3ω-6）转化为花生四烯酸（ARA; 20：4ω-6）和/或二十碳四烯酸的能力的Dgr。5去饱和酶 （ETA; 20：4ω-3）至二十碳五烯酸（EPA; 20：5ω-3）。 公开了分离的核酸片段和重组构建体，其包含编码＆Dgr。5去饱和酶的片段以及在油质酵母中使用这些＆Dgr。5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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9.发明申请公开(公告)号：US20110055973A1
公开(公告)日：2011-03-03
申请号：US12944539
申请日：2010-11-11
Applicant: Howard Glenn Damude , Zhixiong Xue , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Zhixiong Xue , Quinn Qun Zhu
IPC: A01H1/00
CPC classification number: C12N15/8247 , A23K20/158 , A23L33/12 , C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-8 desaturases in plants and oleaginous yeast.
Abstract translation: 分离的核酸片段和包含编码δ-8去饱和酶的片段的重组构建物以及使用这些δ-8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US20110008868A1
公开(公告)日：2011-01-13
申请号：US12922500
申请日：2009-04-03
Applicant: Howard Glenn Damude , Steven Gutteridge , Anthony J. Kinney , Michael W. Lassner , Daniel L. Siehl
Inventor： Howard Glenn Damude , Steven Gutteridge , Anthony J. Kinney , Michael W. Lassner , Daniel L. Siehl
CPC classification number: C12N9/1085 , C07K2319/00 , C12N9/00 , C12N9/0004 , C12N9/0036 , C12N9/0071 , C12N9/0093 , C12N9/1029 , C12N9/16
Abstract: Multizymes (i.e., single polypeptides having at least two independent and separable enzymatic activities) are disclosed for a variety of applications beyond the synthesis of long chain polyunsaturated fatty acids.
Abstract translation: 公开了多长时间（即具有至少两个独立且可分离的酶活性的单一多肽），用于多种不同长链多不饱和脂肪酸合成之外的应用。
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