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1.发明公开公开(公告)号：US20240252436A1
公开(公告)日：2024-08-01
申请号：US18591795
申请日：2024-02-29
发明人： Tian XIE , Yiying ZENG , Jie LI , Zhaowu ZENG
IPC分类号： A61K9/127 , A61K31/015 , A61K31/337 , A61K47/10 , A61K47/24 , A61K47/42 , A61P35/00
CPC分类号： A61K9/1271 , A61K31/015 , A61K31/337 , A61K47/10 , A61K47/24 , A61K47/42 , A61P35/00
摘要： The present disclosure provides a dual-targeting biomimetic liposome with elemene (ELE) and cabazitaxel (CTX), where each 100 mL of the dual-targeting biomimetic liposome with ELE and CTX includes 0.15 g to 0.75 g of the ELE, 0.5 mL to 2.5 mL of absolute ethanol, 0.015 g to 0.07 g of the CTX, 0.25 g to 1 g of oil, 0.25 g to 1 g of a polyethylene glycol (PEG) derivative, 1 g to 5 g of a phospholipid, 0.05 g to 0.2 g of cholesterol, 0.025 g to 0.1 g of distearoyl phosphatidylethanolamine-polyethylene glycol 2000-transferrin (DSPE-PEG2000-Tf), 0.005 g to 0.025 g of a tumor cell membrane protein (CMP), and water as a balance.
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公开(公告)号：US11981630B1
公开(公告)日：2024-05-14
申请号：US18103843
申请日：2023-01-31
发明人： Mingfeng Xu , Xiaohong Deng , Jinfeng Liang , Yidi Chen , Jing Ren , Qin Zhu
IPC分类号： C07C49/747 , A61P35/02 , C07C45/79
CPC分类号： C07C49/747 , A61P35/02 , C07C45/79 , C07C2603/26
摘要： Disclosed are an abietane type diterpene compound, a preparation method and an application thereof, relating to the technical field of anti-tumor compounds, where the compound has a chemical structure as shown in the following formula I:
Leucosceptrum canum is extracted to prepare the abietane type diterpene compound according to the present application, and the prepared compound is effectively applied in inhibiting human lung cancer cell A549 and human myeloid leukemia cell HL-60.-
公开(公告)号：US20240117329A1
公开(公告)日：2024-04-11
申请号：US18489816
申请日：2023-10-18
发明人： Xiabin CHEN , Jianzhuang YAO , Shurong HOU , Xingyu DENG , Yun ZHANG , Junsen TONG
CPC分类号： C12N9/18 , B09C1/10 , C02F3/342 , C12Y301/01084 , C02F2101/38
摘要： Disclosed are a cocaine esterase mutant and use thereof. The cocaine esterase mutant is obtained by mutating a wildtype cocaine esterase, an amino acid sequence of the wildtype cocaine esterase is shown as SEQ ID No.1, the cocaine esterase mutant is T172R/G173Q/L196C/I301C, or additionally added with V116K point mutation, or additionally added with A51 site mutation, and the A51 site mutation is L, Y, V, F or W. Catalytic efficiency of the cocaine esterase mutant screened on a cocaine toxic metabolite benzoylecgonine is greatly improved compared with that of a wildtype enzyme.
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公开(公告)号：US11932717B2
公开(公告)日：2024-03-19
申请号：US18321857
申请日：2023-05-23
发明人： Yuanyuan Liang , Yongjin Li
CPC分类号： C08F283/065 , C02F3/108 , C08J3/075
摘要： Disclosed are a green synthesis method of an antibacterial super-porous hydrogel, a product of the antibacterial super-porous hydrogel and an application of the antibacterial super-porous hydrogel to degradation of various pollutants in wastewater treatment. The super-porous hydrogel based on poly (ionic liquid) is prepared by copolymerization of an imidazole type ionic liquid with double bonds and polyethylene glycol diacrylate (PEGDA) as a cross-linker. In the reaction system, water is a good solvent for the monomer ionic liquid and PEGDA, but a poor solvent for the poly (ionic liquid); when an initial concentration of the ionic liquid is higher than 25%, the phase separation typically proceeds through poly(ionic liquid) formation, interconnected networks with macroporous structure could be obtained by photo-crosslinking.
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公开(公告)号：US20240056299A1
公开(公告)日：2024-02-15
申请号：US18363040
申请日：2023-08-01
发明人： Qi Xie , Xiumei Li , Zixuan Ding , Bin Hu , Xiao Tan
CPC分类号： H04L9/3066 , H04L9/50 , G06Q50/265
摘要： A traffic accident forensics method based on a blockchain is provided. After a traffic accident, the method allows vehicles to carry out a mutual verification and sign a respective accident report. After one of the vehicles verifies with a road side unit, the signed accident report is submitted to the road side unit and uploaded to the blockchain, so as to record the accident report and preventing the accident report from being tampered, and an efficient mutual verification between the vehicle and the road side unit is achieved. The key parameters in the mutual verification process are encrypted based on an elliptic curve algorithm, and thus the security of the whole mutual verification process is improved. A batch verification way for signatures is designed to reduce the compute pressure of a wireless device. Vehicles use dynamic anonymity policies to protect privacy in the forensics method.
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公开(公告)号：US20200369876A1
公开(公告)日：2020-11-26
申请号：US16857735
申请日：2020-04-24
发明人： Yongjin Li , Huihui Xu
IPC分类号： C08L69/00 , C08L67/00 , B29C48/92 , B29C48/395 , C08K5/435
摘要： A transparent and heat-resistant polycarbonate (PC) composite and a preparation method thereof. The PC composite is a blend of a PC, a polyarylester (PAR) and an organic salt. The preparation method includes: drying the PC and the PAR each under vacuum at 80-120° C. for 24-48 h; adding the dried PC, the dried PAR and the organic salt into a melt blending device at a mass ratio of (60-90):(40-10):(0.3-3), and performing melt blending at 250-300° C. to obtain a mixture; and discharging the mixture from the melt blending device, and cooling to normal temperature to obtain a PC composite.
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公开(公告)号：US20240150527A1
公开(公告)日：2024-05-09
申请号：US18382037
申请日：2023-10-19
发明人： Lianbin WU , Hui LI , Yingqian HU , Zaoxia WEN , Wenxiu CHEN
摘要： Disclosed are liquid vinyl functionalized cage-type polyhedral oligomeric silsesquioxane modified by low-molecular-weight polysiloxane and a preparation method thereof. Under the catalytic action of tris(pentafluorophenyl)borane, cage-type octakis (dimethylsiloxy)-T8-silsesquioxane and hetero telechelic polydimethylsiloxane undergo a Piers-Rubinsztajn reaction, to obtain liquid Vi-POSS. Side chains of the liquid vinyl functionalized POSS in the present disclosure are Si—O—Si chain links, have better heat stability than that of common long-carbon-chain side chains, and contain vinyl functional groups capable of participating in chemical reactions, which not only have good mechanical enhancement and heat resistance properties, but also have chemical reactivity.
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公开(公告)号：US20220202635A1
公开(公告)日：2022-06-30
申请号：US17377673
申请日：2021-07-16
发明人： Meijuan CAO , Binyu ZHAO , Guohe FENG , Wei ZHANG , Hangsai WANG , Tong WU , Xiaoxia LUO , Yucai HONG
摘要： An automatic cleaning method and a cleaning bed for a patient of gatism are provided. The cleaning bed includes a bed body, a bed plate is arranged on the bed body and is provided with a through groove therein, a bed bottom plate is arranged on a lower part of the bed body, a lifting mechanism is arranged on the bed bottom plate and is provided with a soft cushion thereon, a fabric bracket is arranged under the bed plate and is provided with a material roller thereon, a pressing roller bracket is arranged under the bed plate and at one side close to the fabric bracket and is provided with provided with a first pressing roller and a second pressing roller.
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公开(公告)号：US20200071259A1
公开(公告)日：2020-03-05
申请号：US16163623
申请日：2018-10-18
发明人： Weiming Xu , Pengfei Zhang , Dongxiang Feng , Lianzhi Tao
IPC分类号： C07C213/08
摘要： The present invention provides a method for preparing levobunolol hydrochloride. In the present invention S-1-tert-butyl-epoxy methylamine is subjected to a substitution reaction with 5-hydroxy-1-tetralone, and acidified to obtain the target product levobunolol hydrochloride. The method provided by the present invention greatly improves the regioselectivity of the reaction, avoids the occurrence of side reactions, and effectively improves the yield and optical purity of levobunolol hydrochloride, with the yield being 87.3%, and the ee value being over 99%.
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10.发明公开公开(公告)号：US20240132456A1
公开(公告)日：2024-04-25
申请号：US18257371
申请日：2022-09-02
发明人： Tian XIE , Renren BAI , Xiangyang YE , Junlong ZHU , Ziqiang BAI
IPC分类号： C07D271/08 , A61P35/00 , C07D413/12
CPC分类号： C07D271/08 , A61P35/00 , C07D413/12
摘要： The disclosure relates to the field of medicinal chemistry. Disclosed are a 14-chloro-β-elemene nitric oxide donor derivative and a preparation method and use thereof in the preparation of anti-tumor drugs. The 14-chloro-β-elemene nitric oxide donor derivative has a general formula shown in formula (I): in formula (I): R1 represents a linear or cyclic alcohol amine structure containing nitrogen and oxygen atoms; and each of R2 and R3 is independently selected from the group consisting of C1-10 alkyl, C3-12 cycloalkyl, C6-12 aryl, 5- to 10-membered cyclic heteroaryl, C2-10 alkenyl, C2-10 alkynyl, and C2-10 alkoxy. In the disclosure, the derivative is superior to the previous β-elemene nitric oxide donor derivatives in terms of the design strategy, an alcohol amine structure that can enhance in vivo anti-tumor activity is introduced as a linker, which improves in vivo stability, and provides good therapeutic activity against malignant brain glioma against which effective therapeutic drugs is short in clinical practice.
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