公开(公告)号：US06372515B1

公开(公告)日：2002-04-16

申请号：US09295095

申请日：1999-04-21

申请人： Douglas Casterlin ,  Henry J. Wells ,  Stan Cipkowski

发明人： Douglas Casterlin ,  Henry J. Wells ,  Stan Cipkowski

IPC分类号： G01N33533

CPC分类号： A61B10/007 ,  A61B10/0096 ,  A61B2010/0003 ,  A61B2010/0009 ,  B01L3/508 ,  G01N33/525 ,  G01N33/54366 ,  G01N33/558 ,  G01N33/94 ,  G01N2001/005 ,  G01N2001/007 ,  G01N2800/52 ,  Y10S435/805 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/81 ,  Y10S436/823

摘要： A test card for drugs of abuse has a thin flat member having the size and shape of a business card. A plurality of immunoassay test strips extend longitudinally from top to bottom at the card and are fastened side by side in parallel on one or both sides of the test card within the outline of the card. Each test strip is reactive to provide a visual indication in response to a particular drug of abuse. The test card thus provides for the simultaneous detection of multiple analytes. Processes are also disclosed for making the drug test card with test strips on one and both sides of the card.

摘要翻译： 用于滥用药物的测试卡具有具有名片尺寸和形状的薄扁平构件。 多个免疫测定条从卡片的顶部到底部纵向延伸，并且在卡的轮廓内的测试卡的一侧或两侧并排并排固定。 每个测试条都是反应性的，以提供响应特定药物滥用的视觉指示。 因此，测试卡提供了多个分析物的同时检测。 还公开了用于使药物测试卡在卡的一侧和两侧具有测试条的方法。

公开(公告)号：US4956300A

公开(公告)日：1990-09-11

申请号：US661273

申请日：1984-10-16

申请人： Henry J. Wells

发明人： Henry J. Wells

IPC分类号： G01N33/72

CPC分类号： G01N33/725 ,  Y10S436/904

摘要： A guaiac reagent-based diagnostic aid for determining the presence of occult blood in an aqueous system contains a micron-sized silica gel into which a guaiac solution has been adsorbed. The guaiac-containing carrier is contacted with a dry, particulate, oxidizing agent, such as a monopersulfate compound, to form a single composition. This composition can be packaged in a water-pervious sandwich. Upon contact with water, the oxidizing agent is activated to produce hydrogen peroxide, which in the presence of occult blood will oxidize the adsorbed guaiac to a brilliant blue reaction product.

摘要翻译： 用于确定含水系统中潜血的存在的基于愈创木酚试剂的诊断助剂含有已经吸附愈创木酚溶液的微米级硅胶。 含有愈创木酚的载体与干燥的颗粒状氧化剂如单过硫酸盐化合物接触以形成单一的组合物。 该组合物可以包装在透水的三明治中。 当与水接触时，氧化剂被活化以产生过氧化氢，其在隐藏血液的存在下会将吸附的愈伤组织氧化成明亮的蓝色反应产物。

公开(公告)号：US06406922B2

公开(公告)日：2002-06-18

申请号：US09770312

申请日：2001-01-29

申请人： Douglas Casterlin ,  Henry J. Wells ,  Stan Cipkowski

发明人： Douglas Casterlin ,  Henry J. Wells ,  Stan Cipkowski

IPC分类号： G01N3353

CPC分类号： B01L3/508 ,  A61B10/007 ,  A61B10/0096 ,  A61B2010/0003 ,  A61B2010/0009 ,  G01N33/525 ,  G01N33/54366 ,  G01N33/558 ,  G01N33/94 ,  G01N2001/005 ,  G01N2001/007 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/816 ,  Y10S436/901

摘要： A drug of abuse test kit for testing low volumes of a fluid sample having a transparent flat bag container for retaining a fluid sample to be tested and the open end of the container has a recloseable closure. The container is maintained in a substantially vertical position and has an open end which receives a multiple drug test card having a plurality of immunoassay test strips thereon with visual endpoints to indicate presence or absence of a particular drug. A process and a modification thereof for testing of low volumes of a fluid sample and a process for quality control of a test card are also disclosed.

摘要翻译： 用于测试低体积流体样品的滥用药物试剂盒，其具有用于保持要测试的流体样品的透明扁平袋容器并且容器的开口端具有可再封闭的封闭件。 容器保持在基本上垂直的位置并且具有开口端，其接收具有多个免疫测定试纸的多个药物测试卡，其上具有可视端点以指示特定药物的存在或不存在。 还公开了用于测试低体积流体样品的过程及其修改以及测试卡的质量控制过程。

公开(公告)号：US4752448A

公开(公告)日：1988-06-21

申请号：US943539

申请日：1986-12-17

申请人： Henry J. Wells ,  Robin L. Binder

发明人： Henry J. Wells ,  Robin L. Binder

IPC分类号： G01N33/493 ,  G01N21/78 ,  G01N30/90 ,  G01N33/52 ,  G01N33/94

CPC分类号： G01N33/948 ,  G01N33/946 ,  G01N33/9486 ,  Y10S436/901 ,  Y10T436/141111 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173845

摘要： A diagnostic test paper detects abuse-type drugs in a test specimen of a biological fluid. A particular method of making the diagnostic test paper includes impregnating a bibulous carrier material with the dry residue of a reagent reactive to abuse-type drugs. A particular method is used for screening a biological fluid to determine the presence of abuse-type drugs therein. A test specimen applying area is located on the bibulous carrier material adjacent one side of a concentrated reagent zone having a first color. A particular method of application and a specific syringe device is used to apply a test specimen that has been prepared under very precise conditions. The test specimen moves from the particular applying area into the concentrated reagent zone to produce the specific results of detecting the presence of abuse-type drugs therein. A novel solvent composition is used to prepare the test specimen applied to the bibulous carrier material of the invention.

摘要翻译： 诊断试纸检测生物流体试样中的滥用药物。 制作诊断试纸的具体方法包括用吸收型药物反应的试剂的干燥残余物浸渍吸水性载体材料。 特定的方法用于筛选生物流体以确定其中滥用型药物的存在。 试样施加区域位于与具有第一颜色的浓缩试剂区域的一侧相邻的吸水性载体材料上。 使用特定的施用方法和特定的注射器装置来施加在非常精确的条件下制备的试样。 试样从特定应用区域移动到浓缩试剂区域，以产生检测其中滥用药物的存在的具体结果。 使用新的溶剂组合物来制备应用于本发明的吸水性载体材料的试样。

公开(公告)号：US4578358A

公开(公告)日：1986-03-25

申请号：US491007

申请日：1983-05-03

申请人： Norman H. Oksman ,  Joseph M. Talmage ,  Henry J. Wells

发明人： Norman H. Oksman ,  Joseph M. Talmage ,  Henry J. Wells

IPC分类号： G01N33/50 ,  C12Q1/28 ,  G01N1/04 ,  G01N21/78 ,  G01N31/22 ,  G01N33/48 ,  G01N33/52 ,  G01N33/72 ,  G01N1/02

CPC分类号： C12Q1/28 ,  G01N33/726

摘要： A test for the presence of occult blood in fecal matter or other bodily substance employs an indicator wipe 2. The indicator wipe 2 has an occult-blood detection-test surface 10 for collecting a specimen and includes a peroxidase-activity indicator reagent dispersed on or located proximate to the specimen collection region. The test involves contacting the specimen-collection region to the bodily substance to obtain a specimen, then applying an oxidizing-agent developing fluid to the specimen and observing any color change to determine if the specimen contains occult blood, and finally disposing of the indicator wipe by placing it in a toilet bowl and flushing it away.

摘要翻译： 在粪便或其他身体物质中存在潜血的测试使用指示剂擦拭物2.指示剂擦拭物2具有用于收集样本的隐血检测试验表面10，并且包括分散在或其上的过氧化物酶活性指示剂 位于样本收集区域附近。 试验包括将样品收集区域接触到身体物质以获得样品，然后向样品施加氧化剂显影液并观察任何颜色变化以确定样品是否含有隐血，最后处理指示剂擦拭 将其放在马桶中并将其冲洗掉。

公开(公告)号：US4578359A

公开(公告)日：1986-03-25

申请号：US491008

申请日：1983-05-03

申请人： Norman H. Oksman ,  Joseph M. Talmage ,  Henry J. Wells

发明人： Norman H. Oksman ,  Joseph M. Talmage ,  Henry J. Wells

IPC分类号： G01N33/50 ,  G01N1/04 ,  G01N21/78 ,  G01N31/22 ,  G01N33/48 ,  G01N33/52 ,  G01N33/72 ,  G01N1/02

CPC分类号： G01N33/726

摘要： A specimen-collection wipe 2 is suitable for use in testing for the presence of occult blood in fecal matter or other bodily substance. The wipe 2 includes a substrate 4 having a hand-contact surface 11 for manipulating the wipe 2 and an occult-blood detection-test surface 10 for collecting a specimen and supporting it during treatment with an occult-blood indicator fluid. The substrate 4 has a sufficiently low wet strength to permit the wipe 2 to be disposed of in a toilet and preferably has a sufficiently high resistance to seepage to permit the hand-contact surface 11 to remain dry for the duration of the test. The wipe 2 also includes an indicator-activity verification region 14 on which is dispersed a reagent capable of interacting with the occult-blood indicator fluid to provide an indication characteristic of the presence of occult blood.

摘要翻译： 标本采集擦拭物2适用于测试粪便物质或其他身体物质中潜血的存在。 擦拭物2包括具有用于操纵擦拭物2的手接触表面11和用于收集样本并在用隐蔽血液指示剂流体治疗期间将其支撑的隐血检测表面10的基底4。 衬底4具有足够低的湿强度以允许将擦拭物2放置在马桶中，并且优选地具有足够高的耐渗漏性，以允许手接触表面11在测试期间保持干燥。 擦拭物2还包括指示剂活性验证区域14，在其上分散有能够与隐血指示液相互作用的试剂，以提供潜血存在的特征。