公开(公告)号：US5064495A

公开(公告)日：1991-11-12

申请号：US379666

申请日：1989-07-13

Applicant: Ikuo Omura ,  Junichi Yamauchi ,  Mitsunobu Kawashima

Inventor： Ikuo Omura ,  Junichi Yamauchi ,  Mitsunobu Kawashima

IPC: C08F18/02 ,  A61K6/00 ,  C08F20/00 ,  C08F20/38 ,  C08F20/52 ,  C08F20/54 ,  C08F28/00 ,  C08F28/02 ,  C09J4/00 ,  C09J4/02

CPC classification number: C09J4/00 ,  A61K6/0085 ,  A61K6/0091

Abstract: There is provided an adhesive comprising (a) a compound having at least one mercapto group or polysulfide group joined to a saturated carbon atom and at least one olefinic double bond and (b) a solvent which does not copolymerize with said compound or a liquid polymerizable monomer which copolymerizes with said compound.

公开(公告)号：US5085726A

公开(公告)日：1992-02-04

申请号：US633959

申请日：1990-12-26

Applicant: Ikuo Omura ,  Junichi Yamauchi ,  Mitsunobu Kawashima

Inventor： Ikuo Omura ,  Junichi Yamauchi ,  Mitsunobu Kawashima

IPC: C08F18/02 ,  A61K6/00 ,  C08F20/00 ,  C08F20/38 ,  C08F20/52 ,  C08F20/54 ,  C08F28/00 ,  C08F28/02 ,  C09J4/00 ,  C09J4/02

CPC classification number: C09J4/00 ,  A61K6/0085 ,  A61K6/0091

Abstract: There is provided an adhesive comprising (a) a compound having at least one mercapto group or polysulfide group joined to a saturated carbon atom and at least one olefinic double bond and (b) a solvent which does not copolymerize with said compound or a liquid polymerizable monomer which copolymerizes with said compound.

公开(公告)号：US06869984B2

公开(公告)日：2005-03-22

申请号：US10171596

申请日：2002-06-17

Applicant: Mitsunobu Kawashima ,  Ikuo Omura ,  Mayumi Yamashita

Inventor： Mitsunobu Kawashima ,  Ikuo Omura ,  Mayumi Yamashita

IPC: A61K6/00 ,  A61K6/083 ,  C08K3/34

CPC classification number: A61K6/0835 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0038 ,  A61K6/083 ,  C08L33/00

Abstract: The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.

Abstract translation: 本发明涉及一种牙科用组合物试剂盒，其包含（A）含有（a）含酸基的可聚合单体和（b）芳族仲胺和/或芳族叔胺的单组分底漆组合物的组合，和 （B）含有（c）聚链烯酸的水泥组合物，（d）可离子浸出的玻璃填料，（e）可聚合单体，（f）水，（g）过氧化物和（h） 亚磺酸。 本发明的牙科用组合物试剂盒易于处理，组合物的固化物与牙齿粘合良好。 该套件可用于恢复蛀牙或受伤的牙齿以及将假体粘合到牙齿上。

公开(公告)号：US5186783A

公开(公告)日：1993-02-16

申请号：US662513

申请日：1991-02-28

Applicant: Mitsunobu Kawashima ,  Ikuo Omura

Inventor： Mitsunobu Kawashima ,  Ikuo Omura

IPC: A61K6/00 ,  A61K6/083 ,  C09J4/00

CPC classification number: C09J4/00

Abstract: An adhesive composition comprising a polymerizable thiocarboxylic acid or a derivative thereof of the general formula ##STR1## wherein X.sub.1 is an oxygen atom or a sulfur atom and where X.sub.1 is an oxygen atom, R.sub.1 is an organic group containing at least one olefinic double bond and R.sub.2 is a mercapto group, and where X.sub.1 is a sulfur atom, R.sub.1 is an organic group and R.sub.2 is a mercapto group, a halogen atom, --OR.sub.3, or --SR.sub.3, where R.sub.3 is a monovalent organic group, and at least one of R.sub.1 and R.sub.3 has at least one olefinic double bond, are useful as primers or adhesives and provide a water-resistant, high-strength bond to noble metal adherends which are used in dental and other applications.

Abstract translation: 一种粘合剂组合物，其包含通式“IMAGE”的可聚合的硫代羧酸或其衍生物，其中X 1是氧原子或硫原子，并且其中X 1是氧原子，R 1是含有至少一个烯属双键的有机基团， R2是巯基，其中X1是硫原子，R1是有机基团，R2是巯基，卤素原子，-OR3或-SR3，其中R3是一价有机基团，以及至少一种 R1和R3具有至少一个烯属双键，可用作底漆或粘合剂，并且在用于牙科和其它应用中的贵金属被粘物上提供耐水，高强度的粘合。

公开(公告)号：US06984673B2

公开(公告)日：2006-01-10

申请号：US10183515

申请日：2002-06-28

Applicant: Mitsunobu Kawashima ,  Ikuo Omura ,  Mayumi Yamashita

Inventor： Mitsunobu Kawashima ,  Ikuo Omura ,  Mayumi Yamashita

IPC: A61K6/08 ,  A61F6/00

CPC classification number: A61K6/0835 ,  A61K6/0023 ,  C08L33/00

Abstract: One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and/or an aromatic tertiary amine.

公开(公告)号：US5254198A

公开(公告)日：1993-10-19

申请号：US892928

申请日：1992-06-03

Applicant: Mitsunobu Kawashima ,  Ikuo Omura

Inventor： Mitsunobu Kawashima ,  Ikuo Omura

IPC: A61K6/00 ,  A61K6/083 ,  C09J4/00 ,  C09J5/02

CPC classification number: C09J4/00 ,  A61K6/0029

Abstract: An adhesive composition comprising a polymerizable thiocarboxylic acid or a derivative thereof of the general formula ##STR1## wherein X.sub.1 is an oxygen atom or a sulfur atom and where X.sub.1 is an oxygen atom, R.sub.1 is an organic group containing at least one olefinic double bond and R.sub.2 is a mercapto group, and where X.sub.1 is a sulfur atom, R.sub.1 is an organic group and R.sub.2 is a mercapto group, a halogen atom, --OR.sub.3, or --SR.sub.3, where R.sub.3 is a monovalent organic group, and at least one of R.sub.1 and R.sub.3 has at least one olefinic double bond, are useful as primers or adhesives and provide a water-resistant, high-strength bond to noble metal adherends which are used in dental and other applications.

Abstract translation: 一种粘合剂组合物，其包含通式“IMAGE”的可聚合的硫代羧酸或其衍生物，其中X 1是氧原子或硫原子，并且其中X 1是氧原子，R 1是含有至少一个烯属双键的有机基团， R2是巯基，其中X1是硫原子，R1是有机基团，R2是巯基，卤素原子，-OR3或-SR3，其中R3是一价有机基团，以及至少一种 R1和R3具有至少一个烯属双键，可用作底漆或粘合剂，并且在用于牙科和其它应用中的贵金属被粘物上提供耐水，高强度的粘合。

公开(公告)号：US5486544A

公开(公告)日：1996-01-23

申请号：US304434

申请日：1994-09-12

Applicant: Mitsunobu Kawashima ,  Ikuo Omura

Inventor： Mitsunobu Kawashima ,  Ikuo Omura

IPC: C08F2/46 ,  A61K6/00 ,  A61K6/083 ,  C08F2/48 ,  C08F2/50 ,  C08F4/00 ,  C08F4/06 ,  C09J4/00

CPC classification number: A61K6/0052 ,  C08F2/50 ,  C08F4/06 ,  Y10S206/813

Abstract: A polymerizable composition comprising:(a) a monomer; and(b) a sulfinate represented by the formula (I): ##STR1## wherein R.sup.1 and R.sup.5 each represents a substituent having 2 to 6 carbon atoms, R.sup.2, R.sup.3 and R.sup.4 each represents an atom or substituent inert to the monomer (a), M.sup.n+ represents a n-valent cation, and n represents an integer of 1 to 4.

Abstract translation: 一种可聚合组合物，其包含：（a）单体; 和（b）由式（I）表示的亚磺酸盐：其中R 1和R 5各自表示具有2至6个碳原子的取代基，R 2，R 3和R 4各自表示对单体惰性的原子或取代基 （a）中，Mn +表示n价阳离子，n表示1〜4的整数。

公开(公告)号：US4537940A

公开(公告)日：1985-08-27

申请号：US659455

申请日：1984-10-10

Applicant: Ikuo Omura ,  Junichi Yamauchi ,  Yoshinori Nagase ,  Fumiko Uemura

Inventor： Ikuo Omura ,  Junichi Yamauchi ,  Yoshinori Nagase ,  Fumiko Uemura

IPC: C08F18/00 ,  A61K6/00 ,  A61L24/06 ,  A61L27/16 ,  C08F18/02 ,  C08F30/02 ,  C09J4/00 ,  C09J4/02 ,  C09J131/00 ,  C09K3/00 ,  C09J3/14

CPC classification number: C09J4/00 ,  A61K6/0073 ,  A61L24/06 ,  A61L27/16 ,  C08F30/02

Abstract: This invention provides an adhesive composition which comprises 1 part by weight of (a) a compound of the general formula: ##STR1## wherein R.sub.1 represents H, a hydrocarbon group of 1-6 carbon atoms optionally containing halogen, COOR', wherein R' represents a hydrocarbon group of 1-20 carbon atoms optionally containing halogen or halogen;R.sub.2 is as defined for R.sub.1 ;R.sub.3 represents H, a hydrocarbon group of 1-6 carbon atoms optionally containing halogen, halogen or CN;R.sub.4 represents (COX.sub.2).sub.m1 (CO).sub.m2 (ZCO).sub.m3 (Z).sub.m4 Ra wherein Ra represents an organic residue of 6-60 carbon atoms and a valency of m+n ; m1, m2, m3 and m4 each represents an integer of 0-4 and satisfies m1+m2+m3+m4.ltoreq.m; X.sub.2 represents O, S or NRb, (wherein Rb represents H or alkyl of 1-4 carbon atoms and Z represents O or S;X.sub.1 is as defined for X.sub.2 ;m is an integer of 1-4;n is an integer of 2-6; andk is 0 or 1,and 0-199 parts by weight of (b) a vinyl monomer copolymerizable with the aforesaid compound. Such an adhesive composition can strongly adhere to any of the hard tissues of the living body, such as teeth and bones, metal materials, organic polymer materials and ceramic materials, and, in particular, has an advantage in that it can maintain high adhesive strength for a long time under wet conditions. While the adhesive composition of this invention may be used in various fields, it is especially useful in the dentistry field.

公开(公告)号：US4347174A

公开(公告)日：1982-08-31

申请号：US256154

申请日：1981-04-21

Applicant: Yoshinori Nagase ,  Kyoichiro Shibatani ,  Junichi Yamauchi ,  Ikuo Omura

Inventor： Yoshinori Nagase ,  Kyoichiro Shibatani ,  Junichi Yamauchi ,  Ikuo Omura

IPC: A61K6/09 ,  C04B26/04 ,  C08F2/44 ,  C08F20/36 ,  A61K6/08 ,  C08F26/02 ,  C08K3/36 ,  C08K5/54

CPC classification number: A61K6/0023 ,  A61K6/083 ,  A61K6/09 ,  C04B26/04 ,  C08F20/36 ,  Y10S522/908

Abstract: A cement composition which comprises a filler, a binder to be used in admixture with the filler, and a curing agent for polymerizing the binder, which is characterized by that the binder comprises, based on the total weight of the binder, 20-100% by weight of (A) a free-radical polymerizable monomer of the following formula: ##STR1## wherein R is a hydrogen atom or a methyl group and X is an organic residue having 1-48 carbon atoms, and 0-80% by weight of (B) a mono-, di- or tri-functional free-radical polymerizable monomer which is copolymerizable with the above monomer (A) is disclosed. By using the above binder, the filler is firmly bonded with each other and gives a cured product having high compressive strength and abrasion resistance. The cement composition is especially useful as dental restorative materials.

Abstract translation: 一种水泥组合物，其包含填料，与填料混合使用的粘合剂和用于聚合粘合剂的固化剂，其特征在于粘合剂基于粘合剂的总重量为20-100重量％ （A）下式的自由基聚合性单体：其中R为氢原子或甲基，X为碳原子数为1〜48的有机残基，0〜80重量％ 公开了（B）可与上述单体（A）共聚的单，二或三官能的可自由基聚合的单体。 通过使用上述粘合剂，填料彼此牢固地结合，得到具有高抗压强度和耐磨性的固化产物。 该水泥组合物特别用作牙科修复材料。

公开(公告)号：US4650847A

公开(公告)日：1987-03-17

申请号：US720012

申请日：1985-04-04

Applicant: Ikuo Omura ,  Junichi Yamauchi ,  Yoshinori Nagase ,  Fumiko Uemura

Inventor： Ikuo Omura ,  Junichi Yamauchi ,  Yoshinori Nagase ,  Fumiko Uemura

IPC: A61K6/00 ,  C07F9/09 ,  C08F4/34 ,  C09J4/00 ,  A61K6/02 ,  C09K3/00

CPC classification number: C09J4/00 ,  A61K6/0088 ,  A61K6/0091 ,  C07F9/091

Abstract: An adhesive composition comprises 100 parts by weight of a polymerizable monomer comprising (a) 1.5 to 100 parts by weight of a compound represented by general formula I or II: ##STR1## where R.sub.1 and R.sub.1 ' each stand for hydrogen or a methyl group, R.sub.2 stands for a divalent organic residue having 4 to 40 carbon atoms, X.sub.1 and X.sub.2 each stand for --O--, --S-- or --NH--, a is 0 or 1, and R.sub.3 stands for a group of the formula ##STR2## having 6 to 40 carbon atoms, where R.sub.4 and R.sub.4 ' each stand for a hydrocarbon group having 1 to 29 carbon atoms, and optionally replaced by a halogen atom, or a hydroxyl, amino or carboxyl group, b is an integer of 0 to 3, and Z stands for --O--, --COO-- or --NH--, a plurality of R.sub.4 ' (when b is 2 or 3) being the same or different, at least one of R.sub.4 and R.sub.4 ' having at least three carbon atoms, and (b) 0 to 98.5 parts by weight of a vinyl monomer copolymerizable with the above compound; and 0.01 to 20 parts by weight of a curing agent. It shows a superior adhesive strength on any of hard tissues in a living body, such as teeth and bones, metals, organic polymers and ceramics. It maintains a high adhesive strength for a long time even if it is exposed to moisture, or immersed in water. It is particularly effective for use in dentistry, though it is useful for a variety of other purposes, too.

Abstract translation: 粘合剂组合物包含100重量份的可聚合单体，其包含（a）1.5至100重量份的由通式I或II表示的化合物：其中R 1和R 1 '各自代表氢或甲基，R2代表具有4-40个碳原子的二价有机残基，X1和X2分别表示-O - ， - S-或-NH-，a是0或1，R3 代表具有6〜40个碳原子的式“IMAGE”的基团，其中R 4和R 4'各自代表具有1至29个碳原子的烃基，并且任选被卤素原子或羟基，氨基或羧基取代 基团，b为0〜3的整数，Z表示-O - ， - COO-或-NH-，多个R 4'（当b为2或3）相同或不同时， R4和R4'具有至少三个碳原子，和（b）0至98.5重量份可与上述化合物共聚的乙烯基单体; 和0.01〜20重量份的固化剂。 它对生物体中的任何硬组织如牙齿和骨骼，金属，有机聚合物和陶瓷显示出优异的粘合强度。 即使暴露于潮湿或浸入水中，也能长时间保持高粘合强度。 它在牙科使用中特别有效，尽管它也适用于各种其他目的。