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公开(公告)号：US09279768B2
公开(公告)日：2016-03-08
申请号：US14230926
申请日：2014-03-31
申请人： Johnson & Johnson AB
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6465
摘要： A fluorescence reader for an optical assay arrangement that includes a polymeric sample substrate having a reaction site-surface and a substrate surface. The fluorescence reader includes a light source arranged to illuminate the reaction site-surface through the substrate surface, and a detector device arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface being configured to increase transmission of emitted fluorescent light by suppression of total internal reflection.
摘要翻译： 一种用于光学测定装置的荧光读取器，其包括具有反应位点表面和基底表面的聚合物样品基底。 荧光读取器包括布置成通过衬底表面照亮反应位点表面的光源，以及检测器装置，其被配置为检测从反应位点表面发射并透射通过衬底表面的荧光，衬底表面被配置为增加 通过抑制全内反射来发射荧光。
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公开(公告)号：US09606112B2
公开(公告)日：2017-03-28
申请号：US14507284
申请日：2014-10-06
申请人： JOHNSON & JOHNSON AB
发明人： Per Ove Öhman , Ib Mendel-Hartvig
IPC分类号： B01L3/00 , G01N33/53 , G01N33/52 , G01N33/558 , G01N35/00
CPC分类号： G01N33/5304 , B01L3/5023 , B01L3/5027 , B01L3/50273 , B01L3/502746 , B01L2300/0681 , B01L2300/0809 , B01L2300/0816 , B01L2300/0825 , B01L2300/0896 , B01L2400/0406 , B01L2400/086 , B01L2400/088 , G01N33/525 , G01N33/558 , G01N2035/00237 , Y10T436/25
摘要： There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.
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公开(公告)号：US20150031586A1
公开(公告)日：2015-01-29
申请号：US14507284
申请日：2014-10-06
申请人： JOHNSON & JOHNSON AB
发明人： Per Ove Öhman , Ib Mendel-Hartvig
IPC分类号： G01N33/53
CPC分类号： G01N33/5304 , B01L3/5023 , B01L3/5027 , B01L3/50273 , B01L3/502746 , B01L2300/0681 , B01L2300/0809 , B01L2300/0816 , B01L2300/0825 , B01L2300/0896 , B01L2400/0406 , B01L2400/086 , B01L2400/088 , G01N33/525 , G01N33/558 , G01N2035/00237 , Y10T436/25
摘要： There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.
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公开(公告)号：US20160354779A1
公开(公告)日：2016-12-08
申请号：US15244039
申请日：2016-08-23
申请人： JOHNSON & JOHNSON AB
发明人： Ove Per Öhman , Ib Mendel-Hartvig
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2300/18 , B01L2400/0406 , B01L2400/086 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T436/25
摘要： A micro fluidic system includes a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.
摘要翻译： 微流体系统包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中液体样品可以通过期望的程序进行处理。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。
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公开(公告)号：US20140212984A1
公开(公告)日：2014-07-31
申请号：US14230926
申请日：2014-03-31
申请人： Johnson & Johnson AB
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6465
摘要： A fluorescence reader for an optical assay arrangement that includes a polymeric sample substrate having a reaction site-surface and a substrate surface. The fluorescence reader includes a light source arranged to illuminate the reaction site-surface through the substrate surface, and a detector device arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface being configured to increase transmission of emitted fluorescent light by suppression of total internal reflection.
摘要翻译： 一种用于光学测定装置的荧光读取器，其包括具有反应位点表面和基底表面的聚合物样品基底。 荧光读取器包括布置成通过衬底表面照亮反应位点表面的光源，以及检测器装置，其被配置为检测从反应位点表面发射并透射通过衬底表面的荧光，衬底表面被配置为增加 通过抑制全内反射来发射荧光。
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