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18 条记录 (耗时 0.032 秒)

    Cancer-associated antigens and methods of their identification and use
    2.
    发明授权
    Cancer-associated antigens and methods of their identification and use 有权
    癌症相关抗原及其鉴定和使用方法

    公开(公告)号：US07226606B2

    公开(公告)日：2007-06-05

    申请号：US11274856

    申请日：2005-11-16

    申请人： James McArthur ,  Ju-Fay Chang ,  Dale Ando ,  Margo Roberts ,  Jonathan Simons ,  William Nelson

    发明人： James McArthur ,  Ju-Fay Chang ,  Dale Ando ,  Margo Roberts ,  Jonathan Simons ,  William Nelson

    IPC分类号： A61K35/12

    CPC分类号： G01N33/57434 ,  G01N33/574 ,  G01N33/6893

    摘要： The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine and proliferation-incompetent tumor cells which express the tumor-associated antigen. Also provided are kits for carrying out the methods of the invention.

    摘要翻译： 本发明提供了新的，分离的肿瘤相关抗原，以及用于在生物样品中鉴定此类抗原的方法，以及筛选生物样品中存在这种抗原的方法，其中所鉴定的肿瘤抗原与来自受试者的血清反应 用包含表达肿瘤相关抗原的细胞因子和增殖不足的肿瘤细胞的疫苗进行治疗。 还提供了用于实施本发明的方法的试剂盒。

    Methods and compositions for treating B cell cancer
    4.
    发明申请
    Methods and compositions for treating B cell cancer 审中-公开
    治疗B细胞癌的方法和组合物

    公开(公告)号：US20060286116A1

    公开(公告)日：2006-12-21

    申请号：US11432235

    申请日：2006-05-11

    申请人： James McArthur ,  Linda Liang

    发明人： James McArthur ,  Linda Liang

    IPC分类号： A61K39/00 ,  G01N33/574

    CPC分类号： A61K38/168 ,  G01N33/57407

    摘要： Disclosed are methods for killing or retarding the growth of a B cell cancer cell, by contacting the cell with a FRIL family member molecule. Also disclosed are methods for determining if a B cell cancer is sensitive to a FRIL family member molecule, or if a B cell cancer patient will benefit from treatment with a FRIL family member molecule, by contacting a B cell cancer cell with the FRIL family member molecule and determining if growth of the cell is retarded. In addition, methods for treating a B cell cancer patient are disclosed, as well as compositions comprising a FRIL family member molecule and a chemotherapeutic, radiotherapeutic, or agent that selectively kills B cells. Also disclosed are methods for locating a B cell cancer in a patient by administering a detectably labeled FRIL family member molecule to the patient and detecting the label.

    摘要翻译： 公开了通过使细胞与FRIL家族成员分子接触来杀死或延缓B细胞癌细胞的生长的方法。 还公开了用于确定B细胞癌是否对FRIL家族成员分子敏感的方法，或者如果B细胞癌患者将受益于用FRIL家族成员分子治疗，则通过使B细胞癌细胞与FRIL家族成员接触 分子并确定细胞的生长是否被延迟。 此外，公开了用于治疗B细胞癌患者的方法，以及包含选择性杀死B细胞的FRIL家族成员分子和化学治疗剂，放射治疗剂或试剂的组合物。 还公开了通过向患者施用可检测标记的FRIL家族成员分子并检测标签来定位患者B细胞癌的方法。

    Tilting mechanism for use with infant bassinette
    8.
    发明授权
    Tilting mechanism for use with infant bassinette 失效
    用于婴儿腰带的倾斜机构

    公开(公告)号：US4819282A

    公开(公告)日：1989-04-11

    申请号：US129811

    申请日：1987-12-07

    申请人： James McArthur ,  Herbert W. Bentz

    发明人： James McArthur ,  Herbert W. Bentz

    IPC分类号： A61G7/005 ,  A61G11/00 ,  A61G7/00

    CPC分类号： A61G11/00 ,  A61G11/008 ,  A61G7/005

    摘要： This invention discloses a two-way tilting mechanism for use with infant bassinettes. It is comprised of a pivotable support adapted to receive an infant bassinette, a base upon which the support is pivotably mounted, a single-action pivoting mechanism connecting the support to the base, locking means for holding the support in a tilted position, and means for releasing the locking means.

    摘要翻译： 本发明公开了一种用于婴儿巴生词的双向倾斜机构。 它包括适于接收婴儿腰带的可枢转支撑件，支撑件可枢转地安装在其上的基座，将支撑件连接到基座的单作用枢转机构，用于将支撑件保持在倾斜位置的锁定装置，以及装置 用于释放锁定装置。

    Coupling assembly
    9.
    发明授权
    Coupling assembly 失效
    联轴器组件

    公开(公告)号：US4792255A

    公开(公告)日：1988-12-20

    申请号：US102452

    申请日：1987-09-29

    申请人： James McArthur ,  Steven E. Hodge

    发明人： James McArthur ,  Steven E. Hodge

    IPC分类号： A63B23/00 ,  B23Q5/54 ,  F16D1/116 ,  G05G1/08 ,  G05G1/12 ,  B25G3/18

    CPC分类号： A63B23/00 ,  B23Q5/54 ,  F16D1/116 ,  G05G1/08 ,  G05G1/12 ,  Y10T403/592 ,  Y10T403/599 ,  Y10T403/604

    摘要： An improved coupling assembly between an actuating member and a shaft is disclosed. It is comprised of locking means on the actuating member for engaging with the shaft in order to secure the actuating member thereto. In addition, an actuating means for actuating the locking means to allow removal of the actuating member is provided. Groove and key means between the actuating member and the shaft is provided to allow the member to be removed longitudinally thereof while preventing rotation of the member about the shaft when the locking means is engaged with the shaft.

    摘要翻译： 公开了一种在致动构件和轴之间的改进的联接组件。 它由致动构件上的锁定装置组成，用于与轴接合以便将致动构件固定到其上。 此外，提供了用于致动锁定装置以允许移除致动构件的致动装置。 提供致动构件和轴之间的槽和钥匙装置，以允许构件沿其纵向移除，同时当锁定装置与轴接合时防止构件围绕轴的旋转。

    Drive unit for exercising apparatus
    10.
    发明授权
    Drive unit for exercising apparatus 失效
    运动装置的驱动单元

    公开(公告)号：US4637607A

    公开(公告)日：1987-01-20

    申请号：US701929

    申请日：1985-02-15

    申请人： James McArthur

    发明人： James McArthur

    IPC分类号： A63B21/22 ,  A63B21/005 ,  A63B21/015

    CPC分类号： A63B21/015

    摘要： A drive unit for providing kinetic frictional resistance to an exercising apparatus which includes a sub-frame with a driving and driven element coupled to the sub-frame a motor coupled to the driving element for rotatably driving the latter. The driving and driven elements are coupled such that the driving and driven elements slip relative to one another. An adjustment is provided for adjusting the kinetic friction force between the driving and driven elements, while a stop is mounted on the sub-frame for blocking the driven element from movement beyond a start position. In operation the driving element is continuously driven by the motor throughout an exercise so that only kinetic friction has to be overcome by a user.

    摘要翻译： 一种驱动单元，用于向运动装置提供动力学摩擦阻力，该运动装置包括具有与子框架联接的驱动元件和从动元件的子框架，马达与驱动元件连接，用于可旋转地驱动该驱动元件。 驱动元件和驱动元件被联接成使得驱动元件和被驱动元件相对于彼此滑动。 提供了用于调节驱动元件与被驱动元件之间的动摩擦力的调整，同时将停止件安装在子框架上以阻止从动元件移动超过起始位置。 在操作中，驱动元件在运动中由马达连续地驱动，使得只有动力摩擦必须由使用者克服。