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    Classification of kinase inhibitors using nonlinear optical techniques
    5.
    发明授权
    Classification of kinase inhibitors using nonlinear optical techniques 有权
    使用非线性光学技术的激酶抑制剂分类

    公开(公告)号：US09428789B2

    公开(公告)日：2016-08-30

    申请号：US14006302

    申请日：2012-03-21

    申请人： Joshua S. Salafsky ,  Ryan McGuinness

    发明人： Joshua S. Salafsky ,  Ryan McGuinness

    IPC分类号： C12Q1/48 ,  G01N33/58 ,  G01N33/68

    CPC分类号： C12Q1/485 ,  G01N33/58 ,  G01N33/6803 ,  G01N2500/00

    摘要： A method is disclosed for classifying and distinguishing between type I and type II kinase inhibitors. The method involves the use of non-linear optical techniques, in particular second-harmonic generation (SHG) to identify conformational changes in kinase proteins obtained from known type I or type II inhibitors. The method further involves deducing the manner of binding of unknown inhibitors by comparison with the signal changes produced by known ligands. The method is also applied to comparing the conformational changes induced by the binding of generic and branded kinase inhibitor drugs to a target kinase.

    摘要翻译： 公开了用于分类和区分I型和II型激酶抑制剂的方法。 该方法涉及使用非线性光学技术，特别是二次谐波产生（SHG）来鉴定从已知的I型或II型抑制剂获得的激酶蛋白质的构象变化。 该方法还涉及通过与已知配体产生的信号变化进行比较来推断未知抑制剂的结合方式。 该方法也用于比较通用和标记激酶抑制剂药物与靶激酶结合诱导的构象变化。

    CLASSIFICATION OF KINASE INHIBITORS USING NONLINEAR OPTICAL TECHNIQUES
    6.
    发明申请
    CLASSIFICATION OF KINASE INHIBITORS USING NONLINEAR OPTICAL TECHNIQUES 有权
    使用非线性光学技术对激素抑制剂进行分类

    公开(公告)号：US20140113312A1

    公开(公告)日：2014-04-24

    申请号：US14006302

    申请日：2012-03-21

    申请人： Joshua S. Salafsky ,  Ryan McGuinness

    发明人： Joshua S. Salafsky ,  Ryan McGuinness

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/485 ,  G01N33/58 ,  G01N33/6803 ,  G01N2500/00

    摘要： A method is disclosed for classifying and distinguishing between type I and type II kinase inhibitors. The method involves the use of non-linear optical techniques, in particular second-harmonic generation (SHG) to identify conformational changes in kinase proteins obtained from known type I or type II inhibitors. The method further involves deducing the manner of binding of unknown inhibitors by comparison with the signal changes produced by known ligands. The method is also applied to comparing the conformational changes induced by the binding of generic and branded kinase inhibitor drugs to a target kinase.

    摘要翻译： 公开了用于分类和区分I型和II型激酶抑制剂的方法。 该方法涉及使用非线性光学技术，特别是二次谐波产生（SHG）来鉴定从已知的I型或II型抑制剂获得的激酶蛋白质的构象变化。 该方法还涉及通过与已知配体产生的信号变化进行比较来推断未知抑制剂的结合方式。 该方法也用于比较通用和标记激酶抑制剂药物与靶激酶结合诱导的构象变化。