公开(公告)号：US20060244935A1

公开(公告)日：2006-11-02

申请号：US11402788

申请日：2006-04-12

Applicant: James Overbeck ,  Richard Van Andel

Inventor： James Overbeck ,  Richard Van Andel

IPC: G03B27/80

CPC classification number: G01N21/25 ,  G01J3/50 ,  G01J3/501 ,  G01N21/643 ,  G01N2021/4742 ,  G01N2021/575 ,  G01N2021/6439 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0633 ,  G03B27/80 ,  G06K9/00577 ,  G06K9/2036 ,  G06T7/0004 ,  G06T7/90

Abstract: A method for measuring a flexible colored material during a manufacturing process. The method includes automatically diverting the flexible material from a process path, placing the flexible material in contact with a rotatable drum, and measuring spectral data of the flexible material as the drum rotates. Measuring the spectral data includes scanning the flexible material with a line scanning detector having an array of detectors. The method also includes processing scan information to form a single image of the flexible material.

公开(公告)号：US20050122518A1

公开(公告)日：2005-06-09

申请号：US10991453

申请日：2004-11-18

Applicant: James Overbeck ,  Michael Galen ,  Richard Van Andel ,  Christian Boes

Inventor： James Overbeck ,  Michael Galen ,  Richard Van Andel ,  Christian Boes

IPC: G01J3/51 ,  A61B1/00 ,  A61B1/04 ,  A61B1/24 ,  A61B5/00 ,  G01N21/27 ,  G01N21/57 ,  G01N21/25

CPC classification number: A61B1/24 ,  A61B1/00052 ,  A61B1/00186 ,  A61B1/0669 ,  A61B5/0088 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/465 ,  G01J3/508 ,  G01J3/51

Abstract: An instrument and related process for measuring color, shade, gloss, shape and/or translucence of a tooth. First, the instrument uses searchlight illumination to illuminate a tooth with constant irradiance. Second, the instrument uses colorimetric imaging to collect time-separated frames of different wavelengths of light reflected from a tooth and to combine those frames into a color image. Third, the instrument includes a sanitary shield to establish a reference color and a predetermined distance to a target tooth. Fourth, the instrument provides line-of-sight viewing so an operator may simultaneously view a display of the image on the instrument and the object being measured. Fifth, the instrument is impervious to pollutants because it incorporates a sealed measurement window. Sixth, optical measurements of a tooth taken by a dentist are compared to optical measurements of a prosthetic restoration for that tooth to confirm satisfactory matching of optical characteristics of the tooth and restoration.

Abstract translation: 用于测量牙齿的颜色，阴影，光泽，形状和/或半透明度的仪器和相关过程。 首先，仪器使用探照灯照明照射具有恒定辐照度的牙齿。 其次，仪器使用比色成像来收集从牙齿反射的不同波长的光的时间分隔的帧，并将这些帧组合成彩色图像。 第三，仪器包括卫生护罩以建立参考颜色并且与目标牙齿具有预定距离。 第四，仪器提供视线观看，因此操作者可以同时观察仪器上的图像显示和正被测量的物体。 第五，仪器不含污染物，因为它包含一个密封的测量窗口。 第六，将由牙医取得的牙齿的光学测量值与该牙齿的假体修复体的光学测量值进行比较，以确认牙齿和修复体的光学特性的令人满意的匹配。

公开(公告)号：US20050243320A1

公开(公告)日：2005-11-03

申请号：US11116826

申请日：2005-04-28

Applicant: Richard Van Andel ,  James Overbeck

Inventor： Richard Van Andel ,  James Overbeck

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/28 ,  G01J3/50 ,  G01J3/51 ,  G01N21/47

CPC classification number: G01J3/51 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0235 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/50 ,  G01J3/501 ,  G01J3/513 ,  G01J2003/1213

Abstract: A color measurement instrument includes a housing and illuminators, a two-dimensional photodetector array, and an optics system within the housing. A UV filter wheel closes the housing to prevent contaminants from entering the housing. The filter wheel supports UV filters and non-UV glass that can be selectively aligned with the illuminators. The photodetectors can be read in parallel, and each photodetector includes a unique spectral filter. The optics system delivers light from the sample target area equally to each of the photodetectors.

Abstract translation: 一种颜色测量仪器包括壳体和照明器，二维光电检测器阵列和壳体内的光学系统。 UV滤光轮关闭外壳，以防止污染物进入外壳。 过滤轮支持紫外线过滤器和非UV玻璃，可以选择性地与照明器对准。 可以并行读取光电检测器，并且每个光电检测器包括唯一的光谱滤波器。 光学系统将光从样品目标区域均匀地传送到每个光电检测器。

公开(公告)号：US20060103837A1

公开(公告)日：2006-05-18

申请号：US11321108

申请日：2005-12-29

Applicant: James Overbeck ,  Richard Van Andel

Inventor： James Overbeck ,  Richard Van Andel

IPC: G01B11/26

CPC classification number: G01N21/4738 ,  G01J3/508 ,  G01N21/57 ,  G01N21/8806 ,  G01N2021/4735

Abstract: Imaging that uses glare to confirm proper measurement of a sample. An imaging device illuminates an object and generates glare (i.e., specular reflection, diffuse reflection or a combination of the two) off the object's surface, which is displayed on a display as a glare artifact. The location of the glare artifact is compared to a predetermined location to establish adjustment to obtain a desired angular orientation. The imaging device optionally highlights the glare artifact and steers a user to obtain the desired presentation angle. In two other embodiments, the spatial relationship between the imaging device and the object is time-varied. In one, the imaging device monitors changing glare and acquires a measurement when a desired glare is detected. In the other, the imaging device captures multiple images including varying glare artifacts and analyzes the images to select a preferred image having a glare artifact indicative of a desired angular orientation.

公开(公告)号：US20050243319A1

公开(公告)日：2005-11-03

申请号：US11116534

申请日：2005-04-28

Applicant: Richard Van Andel ,  James Overbeck

Inventor： Richard Van Andel ,  James Overbeck

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/28 ,  G01J3/50 ,  G01J3/51 ,  G01N21/47

CPC classification number: G01J3/51 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0235 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/50 ,  G01J3/501 ,  G01J3/513 ,  G01J2003/1213

Abstract: A color measurement instrument includes a housing and illuminators, a two-dimensional photodetector array, and an optics system within the housing. A UV filter wheel closes the housing to prevent contaminants from entering the housing. The filter wheel supports UV filters and non-WV glass that can be selectively aligned with the illuminators. The photodetectors can be read in parallel, and each photodetector includes a unique spectral filter. The optics system delivers light from the sample target area equally to each of the photodetectors.

Abstract translation: 一种颜色测量仪器包括壳体和照明器，二维光电检测器阵列和壳体内的光学系统。 UV滤光轮关闭外壳，以防止污染物进入外壳。 滤光轮支持可以选择性地与照明器对准的UV滤光片和非WV玻璃。 可以并行读取光电检测器，并且每个光电检测器包括唯一的光谱滤波器。 光学系统将光从样品目标区域均匀地传送到每个光电检测器。

公开(公告)号：US07983467B2

公开(公告)日：2011-07-19

申请号：US12704350

申请日：2010-02-11

Applicant: Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

Inventor： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

IPC: G06K9/00

CPC classification number: G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

公开(公告)号：US20120235016A1

公开(公告)日：2012-09-20

申请号：US13480888

申请日：2012-05-25

Applicant: Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleinik-Ovod

Inventor： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleinik-Ovod

IPC: H01L27/146

CPC classification number: G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。

公开(公告)号：US20050057676A1

公开(公告)日：2005-03-17

申请号：US10975788

申请日：2004-10-27

Applicant: Nathan Weiner ,  Patrick Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas Regan ,  David Bradbury ,  Eric McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

Inventor： Nathan Weiner ,  Patrick Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas Regan ,  David Bradbury ,  Eric McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

IPC: G01N21/64 ,  G01N21/25 ,  G01N33/483 ,  G01N33/53 ,  G01N37/00 ,  G01J3/30

CPC classification number: G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

Abstract: An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

Abstract translation: 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。

公开(公告)号：US20050285049A1

公开(公告)日：2005-12-29

申请号：US11145529

申请日：2005-06-03

Applicant: Jean Montagu ,  James Overbeck

Inventor： Jean Montagu ,  James Overbeck

IPC: G01N21/64 ,  G02B21/16

CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N21/6452 ,  G02B21/16

Abstract: Microscopes, including viewing and other microscopic systems, employ a hinged, tiltable plate to adjust focus on a flat object such as a microscope slide or biochip by motion, achieved by tilting, which is substantially normal to the focus point on the plane of the object. By employing two such tiltable arrangements, relatively long scan lines of e.g., flying objective, single pixel on-axis scanning can be accommodated. The tilting support plate is specifically constructed to provide tailored locations for different objects in series along the Y axis of the plate. The plate can accommodate heaters and cooled plates and/or the flat object being examined. In a fluorescence scanning microscope, locations are specifically adapted to receive microscope slides and biochip cartridges such as Affymetrix's “Gene Chip®”. A scanning microscope under computer control, employing such a focusing action, enables unattended scanning of biochips with a simple and economical instrument. Also shown are flexure-mounting of a support plate to define the hinge axis, techniques for automatically determining position and focus, and a rotatably oscillating flying micro-objective scanner combined with the tilting plane focus system. Construction and control techniques are shown that realize simple and accurate focusing. Methods of examination of biological materials are disclosed. Simple and efficient focused scanning with a flying micro-objective of ordered arrays of nucleotides and nucleic acid fragments carried upon a microscope slide or other substrate is disclosed. Quantified fluorescence imaging is economically achieved by combined use of the described scanning and focusing arrangement and use of simple and accurate calibration modules respectively for example for Affymetrix's “Gene Chip” microarray modules and for microscope slides.

Abstract translation: 显微镜，包括观察和其他微观系统，采用铰接的可倾斜板，以通过倾斜来调节焦点在诸如显微镜载玻片或生物芯片的平面物体上，该倾斜基本上垂直于物体平面上的焦点 。 通过采用两个这样的可倾斜布置，例如飞行物镜的相对长的扫描线可以容纳单个像素的轴上扫描。 倾斜支撑板被特别地构造成为沿着板的Y轴串联的不同物体提供定制的位置。 该板可容纳加热器和冷却板和/或被检查的平面物体。 在荧光扫描显微镜中，位置特别适用于接收显微镜载片和生物芯片盒，如Affymetrix的“Gene Chip”。 采用这种聚焦作用的计算机控制下的扫描显微镜可以通过简单经济的仪器进行无人值守的生物芯片扫描。 还示出了支撑板的弯曲安装以限定铰链轴线，用于自动确定位置和焦点的技术以及与倾斜平面聚焦系统组合的可旋转摆动的飞行微型物体扫描仪。 显示了实现简单准确聚焦的结构和控制技术。 公开了生物材料的检测方法。 公开了用显微镜载玻片或其它基底上携带的核苷酸和核酸片段的有序阵列的飞行微观目标的简单有效的聚焦扫描。 通过组合使用所述的扫描和聚焦装置以及分别使用简单且精确的校准模块，例如Affymetrix的“Gene Chip”微阵列模块和显微镜幻灯片，经济地实现了定量荧光成像。

公开(公告)号：US20050278004A1

公开(公告)日：2005-12-15

申请号：US11102985

申请日：2005-04-11

Applicant: Roger Steinert ,  James Overbeck

Inventor： Roger Steinert ,  James Overbeck

IPC: A61B3/113 ,  A61F9/008 ,  A61F9/01 ,  A61N1/00

CPC classification number: A61B3/113 ,  A61F9/00802 ,  A61F2009/00846 ,  A61F2009/00872

Abstract: A laser system for treating an eye having a cornea, the laser system including a laser beam source capable of generating a laser beam, an eye position detector which includes at least a corneal tracker, the corneal tracker being responsive to movement of an anterior portion of the cornea, the corneal tracker constructed to detect movement of the cornea based on a set of spaced apart optical manifestations from the outer surface of the anterior portion of the cornea, and a beam controller, the beam controller being responsive to the eye position detector to direct the laser beam with controlled energy from the laser beam source to a desired location on the eye.

Abstract translation: 一种用于治疗具有角膜的眼睛的激光系统，所述激光系统包括能够产生激光束的激光束源，至少包括角膜跟踪器的眼睛位置检测器，所述角膜跟踪器响应于所述角膜跟踪器的前部的运动， 所述角膜，所述角膜跟踪器被构造成基于从所述角膜的前部的外表面的一组间隔开的光学表现来检测所述角膜的运动，以及光束控制器，所述光束控制器响应于所述眼睛位置检测器 将具有受控能量的激光束从激光束源引导到眼睛上的期望位置。