公开(公告)号：US20060154961A1

公开(公告)日：2006-07-13

申请号：US11251846

申请日：2005-10-18

Applicant: Qingping Zeng ,  Guomin Yao ,  George Wohlhieter ,  Vellarkad Viswanadhan ,  Andrew Tasker ,  James Rider ,  Holger Monenschein ,  Celia Dominguez ,  Matthew Bourbeau

Inventor： Qingping Zeng ,  Guomin Yao ,  George Wohlhieter ,  Vellarkad Viswanadhan ,  Andrew Tasker ,  James Rider ,  Holger Monenschein ,  Celia Dominguez ,  Matthew Bourbeau

IPC: C07D417/02 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4745

CPC classification number: C07D417/14 ,  C07D417/04 ,  C07D471/04

Abstract: The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及可用于治疗由蛋白激酶B（PKB）介导的疾病的噻二唑化合物。 本发明还涉及这种噻二唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

公开(公告)号：US20140276492A1

公开(公告)日：2014-09-18

申请号：US14204671

申请日：2014-03-11

Applicant: Benjamin Andrew Pratt ,  Colin John Hall ,  Christopher Brian Locke ,  Elliott James Rider ,  Gareth Stephenson

Inventor： Benjamin Andrew Pratt ,  Colin John Hall ,  Christopher Brian Locke ,  Elliott James Rider ,  Gareth Stephenson

IPC: A61M1/00

CPC classification number: A61M1/0094 ,  A61M1/0001 ,  A61M1/0015 ,  A61M1/0052 ,  A61M1/0088 ,  A61M1/0096 ,  A61M2205/21 ,  A61M2205/7536 ,  Y10T29/49826

Abstract: A system and apparatus for treating a tissue site with reduced pressure and collecting fluids from the tissue site is disclosed. The system may include a reduced-pressure source, a pouch in fluid communication with the reduced pressure source, and a dressing in fluid communication with the pouch. The pouch may include a first wall, a second wall having a periphery coupled to the first wall to form an interior, and a third wall extending through the interior to form a first chamber in fluid communication with the dressing and a second chamber in fluid communication with the reduced pressure source. A plurality of filters are positioned in the third wall. The filters permit fluid communication between the first chamber and the second chamber.

Abstract translation: 公开了一种用于以减压处理组织部位并从组织部位收集流体的系统和装置。 该系统可以包括减压源，与减压源流体连通的袋以及与袋流体连通的敷料。 袋可以包括第一壁，第二壁，其具有连接到第一壁以形成内部的周边，以及延伸穿过内部以形成与敷料流体连通的第一室和流体连通的第二室的第三壁 减压源。 多个过滤器定位在第三壁中。 过滤器允许第一室和第二室之间的流体连通。

公开(公告)号：US20090275592A1

公开(公告)日：2009-11-05

申请号：US12218754

申请日：2008-07-16

Applicant: Qingping ZENG ,  Dawei ZHANG ,  Guomin YAO ,  George E. WOHLHIETER ,  Xianghong WANG ,  James RIDER ,  Andreas REICHELT ,  Holger MONENSCHEIN ,  Fang-Tsao HONG ,  James R. FALSEY ,  Celia DOMINGUEZ ,  Matthew P. BOURBEAU ,  John G. ALLEN

Inventor： Qingping ZENG ,  Dawei ZHANG ,  Guomin YAO ,  George E. WOHLHIETER ,  Xianghong WANG ,  James RIDER ,  Andreas REICHELT ,  Holger MONENSCHEIN ,  Fang-Tsao HONG ,  James R. FALSEY ,  Celia DOMINGUEZ ,  Matthew P. BOURBEAU ,  John G. ALLEN

IPC: A61K31/502 ,  C07D237/26 ,  A61P35/00

CPC classification number: C07D413/04 ,  C07D263/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04

Abstract: The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及用于治疗由蛋白激酶B（PKB）介导的疾病的式I的杂环化合物及其组合物，其中变量具有本文提供的定义。 本发明还涉及这些化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

公开(公告)号：US20140276274A1

公开(公告)日：2014-09-18

申请号：US14206396

申请日：2014-03-12

Applicant: Rob Clare ,  Elliott James Rider

Inventor： Rob Clare ,  Elliott James Rider

IPC: A61H1/00

CPC classification number: A61H1/008 ,  A61F13/064 ,  Y10T29/49826

Abstract: A compression therapy apparatus for applying therapeutic compression to a limb includes a bandage having a trunk, a first end, a second end, and a compression line between the first end and the second end. The apparatus also includes a plurality of compression control members disposed on the trunk along the compression line. Each compression control member defines a compression zone and is adapted to independently control a therapeutic compression associated with the compression zone. The plurality of compression control members are configured to provide a substantially continuous compression profile along the compression line.

Abstract translation: 用于对肢体施加治疗压缩的压缩治疗装置包括在第一端和第二端之间具有躯干，第一端，第二端和压缩线的绷带。 该装置还包括沿着压缩线设置在躯干上的多个压缩控制构件。 每个压缩控制构件限定压缩区域并且适于独立地控制与压缩区域相关联的治疗压缩。 多个压缩控制构件被构造成沿着压缩线提供基本上连续的压缩轮廓。

公开(公告)号：US07897619B2

公开(公告)日：2011-03-01

申请号：US12218754

申请日：2008-07-16

Applicant: Qingping Zeng ,  Dawei Zhang ,  Guomin Yao ,  George E. Wohlhieter ,  Xianghong Wang ,  James Rider ,  Andreas Reichelt ,  Holger Monenschein ,  Fang-Tsao Hong ,  James R. Falsey ,  Celia Dominguez ,  Matthew P. Bourbeau ,  John G. Allen

Inventor： Qingping Zeng ,  Dawei Zhang ,  Guomin Yao ,  George E. Wohlhieter ,  Xianghong Wang ,  James Rider ,  Andreas Reichelt ,  Holger Monenschein ,  Fang-Tsao Hong ,  James R. Falsey ,  Celia Dominguez ,  Matthew P. Bourbeau ,  John G. Allen

IPC: A61K31/47 ,  A61K31/416 ,  C07D217/02 ,  C07D231/56

CPC classification number: C07D413/04 ,  C07D263/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04

Abstract: The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及用于治疗由蛋白激酶B（PKB）介导的疾病的式I的杂环化合物及其组合物，其中变量具有本文提供的定义。 本发明还涉及这些化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

公开(公告)号：US20070173506A1

公开(公告)日：2007-07-26

申请号：US11652728

申请日：2007-01-11

Applicant: Qingping Zeng ,  John Allen ,  Matthew Bourbeau ,  Celia Dominguez ,  Christopher Fotsch ,  Nianhe Han ,  Fang-Tsao Hong ,  Xin Huang ,  Matthew Lee ,  Aiwen Li ,  Qingyian Liu ,  James Rider ,  Seifu Tadesse ,  Andrew Tasker ,  Vellarkad Viswanadhan ,  Xianghong Wang ,  Kurt Weiler ,  George Wohlhieter ,  Guomin Yao ,  Chester Yuan

Inventor： Qingping Zeng ,  John Allen ,  Matthew Bourbeau ,  Celia Dominguez ,  Christopher Fotsch ,  Nianhe Han ,  Fang-Tsao Hong ,  Xin Huang ,  Matthew Lee ,  Aiwen Li ,  Qingyian Liu ,  James Rider ,  Seifu Tadesse ,  Andrew Tasker ,  Vellarkad Viswanadhan ,  Xianghong Wang ,  Kurt Weiler ,  George Wohlhieter ,  Guomin Yao ,  Chester Yuan

IPC: A61K31/502 ,  A61K31/4745 ,  A61K31/4709 ,  A61K31/427 ,  C07D417/02

CPC classification number: C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。