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公开(公告)号：US20060154961A1
公开(公告)日：2006-07-13
申请号：US11251846
申请日：2005-10-18
申请人： Qingping Zeng , Guomin Yao , George Wohlhieter , Vellarkad Viswanadhan , Andrew Tasker , James Rider , Holger Monenschein , Celia Dominguez , Matthew Bourbeau
发明人： Qingping Zeng , Guomin Yao , George Wohlhieter , Vellarkad Viswanadhan , Andrew Tasker , James Rider , Holger Monenschein , Celia Dominguez , Matthew Bourbeau
IPC分类号： C07D417/02 , A61K31/433 , A61K31/4709 , A61K31/4745
CPC分类号： C07D417/14 , C07D417/04 , C07D471/04
摘要： The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及可用于治疗由蛋白激酶B（PKB）介导的疾病的噻二唑化合物。 本发明还涉及这种噻二唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。
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公开(公告)号：US20070173506A1
公开(公告)日：2007-07-26
申请号：US11652728
申请日：2007-01-11
申请人： Qingping Zeng , John Allen , Matthew Bourbeau , Celia Dominguez , Christopher Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew Lee , Aiwen Li , Qingyian Liu , James Rider , Seifu Tadesse , Andrew Tasker , Vellarkad Viswanadhan , Xianghong Wang , Kurt Weiler , George Wohlhieter , Guomin Yao , Chester Yuan
发明人： Qingping Zeng , John Allen , Matthew Bourbeau , Celia Dominguez , Christopher Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew Lee , Aiwen Li , Qingyian Liu , James Rider , Seifu Tadesse , Andrew Tasker , Vellarkad Viswanadhan , Xianghong Wang , Kurt Weiler , George Wohlhieter , Guomin Yao , Chester Yuan
IPC分类号： A61K31/502 , A61K31/4745 , A61K31/4709 , A61K31/427 , C07D417/02
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US07354944B2
公开(公告)日：2008-04-08
申请号：US11251846
申请日：2005-10-18
申请人： Qingping Zeng , Guomin Yao , George Erich Wohlhieter , Vellarkad N. Viswanadhan , Andrew Tasker , James Thomas Rider , Holger Monenschein , Celia Dominguez , Matthew Paul Bourbeau
发明人： Qingping Zeng , Guomin Yao , George Erich Wohlhieter , Vellarkad N. Viswanadhan , Andrew Tasker , James Thomas Rider , Holger Monenschein , Celia Dominguez , Matthew Paul Bourbeau
IPC分类号： A61K31/433 , A61K31/4725 , A61K31/416 , A61K31/4162 , C07D285/135 , C07D217/02 , C07D405/04 , C07D417/04 , C07D217/00
CPC分类号： C07D417/14 , C07D417/04 , C07D471/04
摘要： The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及可用于治疗由蛋白激酶B（PKB）介导的疾病的噻二唑化合物。 本发明还涉及这种噻二唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。
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公开(公告)号：US07897619B2
公开(公告)日：2011-03-01
申请号：US12218754
申请日：2008-07-16
申请人： Qingping Zeng , Dawei Zhang , Guomin Yao , George E. Wohlhieter , Xianghong Wang , James Rider , Andreas Reichelt , Holger Monenschein , Fang-Tsao Hong , James R. Falsey , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
发明人： Qingping Zeng , Dawei Zhang , Guomin Yao , George E. Wohlhieter , Xianghong Wang , James Rider , Andreas Reichelt , Holger Monenschein , Fang-Tsao Hong , James R. Falsey , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
IPC分类号： A61K31/47 , A61K31/416 , C07D217/02 , C07D231/56
CPC分类号： C07D413/04 , C07D263/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04
摘要： The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及用于治疗由蛋白激酶B（PKB）介导的疾病的式I的杂环化合物及其组合物，其中变量具有本文提供的定义。 本发明还涉及这些化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。
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公开(公告)号：US07919504B2
公开(公告)日：2011-04-05
申请号：US12218523
申请日：2008-07-15
申请人： Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , Andreas Reichelt , Qingyian Liu , Matthew R. Lee , Xin Huang , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
发明人： Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , Andreas Reichelt , Qingyian Liu , Matthew R. Lee , Xin Huang , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
IPC分类号： A61K31/47 , C07D401/04
CPC分类号： C07D285/135 , C07D417/04 , C07D417/14 , C07D495/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US20090270445A1
公开(公告)日：2009-10-29
申请号：US12378195
申请日：2009-02-11
申请人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
发明人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
IPC分类号： A61K31/427 , A61K31/437 , A61P35/00
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.
摘要翻译： 本发明涉及使用式I和式II的噻唑化合物及其组合物用于治疗由蛋白激酶B（PKB）介导的疾病，例如癌症和其它增殖性疾病，其中变量具有本文提供的定义。
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公开(公告)号：US08084479B2
公开(公告)日：2011-12-27
申请号：US12378195
申请日：2009-02-11
申请人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
发明人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
IPC分类号： A01N43/38 , A01N43/78 , A61K31/405 , A61K31/425 , C07D277/00
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.
摘要翻译： 本发明涉及使用式I和式II的噻唑化合物及其组合物用于治疗由蛋白激酶B（PKB）介导的疾病，例如癌症和其它增殖性疾病，其中变量具有本文提供的定义。
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公开(公告)号：US20090298836A1
公开(公告)日：2009-12-03
申请号：US12218523
申请日：2008-07-15
申请人： Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , Andreas Reichelt , Qingyian Liu , Matthew R. Lee , Xin Huang , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
发明人： Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , Andreas Reichelt , Qingyian Liu , Matthew R. Lee , Xin Huang , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
IPC分类号： A61K31/502 , C07D417/10 , A61K31/433 , C07D417/04 , A61K31/4365 , A61P35/00 , A61K31/4439 , A61K31/4725 , C07D417/14 , A61K31/517
CPC分类号： C07D285/135 , C07D417/04 , C07D417/14 , C07D495/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US07514566B2
公开(公告)日：2009-04-07
申请号：US11652728
申请日：2007-01-11
申请人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
发明人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US20060040956A1
公开(公告)日：2006-02-23
申请号：US11234713
申请日：2005-09-23
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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