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1.发明申请AROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHONATE (S1P) RECEPTOR ACTIVITY 失效具有丝氨酸1-磷酸（S1P）受体活性的芳香化合物公开(公告)号：US20130018019A1
公开(公告)日：2013-01-17
申请号：US13569243
申请日：2012-08-08
申请人： Janet A. Takeuchi , Ling Li , Xiaoxia Liu
发明人： Janet A. Takeuchi , Ling Li , Xiaoxia Liu
IPC分类号： A61K31/675 , A61K31/661 , A61P29/00 , A61P19/02 , A61P37/06 , A61P9/00 , A61P27/02 , A61P1/00 , A61P17/00 , A61P25/00 , A61K31/662 , A61P17/06
CPC分类号： C07F9/3808 , C07F9/5355 , C07F9/572 , C07F9/58 , C07F9/65583 , C07F9/65586
摘要： Novel aromatic compounds which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 可用作鞘氨醇-1-磷酸调节剂的新型芳族化合物，可用于治疗与调节鞘氨醇-1-磷酸受体相关的各种疾病。
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2.发明授权Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US07226951B2
公开(公告)日：2007-06-05
申请号：US11014460
申请日：2004-12-16
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： A61K31/135 , C07C62/00 , C07C69/52 , C07C211/16
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 在说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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3.发明授权Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US07638648B2
公开(公告)日：2009-12-29
申请号：US11728313
申请日：2007-03-23
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： C07D265/06 , C07D263/02 , C07D277/02 , C07D213/02 , C07D333/04 , C07D307/34 , C07C229/34
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 本说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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![7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity](/abs-image/US/2005/05/03/US06887896B1/abs.jpg.150x150.jpg)
4.发明授权7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity 失效7 - [（7-烷氧基） - 色烯-3-烯-6-基] - 庚三烯酸和具有血清葡萄糖降低的7 - [（3-烷氧基）-5,6-二氢萘-2-基] - 庚二酸衍生物 活动公开(公告)号：US06887896B1
公开(公告)日：2005-05-03
申请号：US10696748
申请日：2003-10-29
申请人： Richard L. Beard , Tien T. Duong , Janet A. Takeuchi , Ling Li , Kwok Yin Tsang , Xiaoxia Liu , Jayasree Vasudevan , Liming Wang , Santosh C. Sinha , Haiqing Yuan , Roshantha A. Chandraratna
发明人： Richard L. Beard , Tien T. Duong , Janet A. Takeuchi , Ling Li , Kwok Yin Tsang , Xiaoxia Liu , Jayasree Vasudevan , Liming Wang , Santosh C. Sinha , Haiqing Yuan , Roshantha A. Chandraratna
IPC分类号： A61K31/21 , A61K31/335 , C07C59/72 , C07C69/587 , C07C69/734 , C07D311/58 , A61K31/35 , A61K31/19 , A61K31/235
CPC分类号： C07C69/734 , C07C59/72 , C07C2601/02 , C07C2602/28 , C07D311/58
摘要： Compounds of the formula where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.
摘要翻译： 其中变化具有本说明书中定义的含义的式的化合物能够降低糖尿病哺乳动物中的血清葡萄糖水平，而没有暂时增加甘油三酯水平和降低血清甲状腺素水平的不良副作用。
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5.发明授权Aromatic compounds having sphingosine-1-phosphonate (S1P) receptor activity 失效具有鞘氨醇-1-膦酸酯（S1P）受体活性的芳族化合物公开(公告)号：US08513220B2
公开(公告)日：2013-08-20
申请号：US13569243
申请日：2012-08-08
申请人： Janet A. Takeuchi , Ling Li , Xiaoxia Liu
发明人： Janet A. Takeuchi , Ling Li , Xiaoxia Liu
IPC分类号： A61K31/675 , A61K31/661 , A61K31/662 , A61P1/00 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P37/06
CPC分类号： C07F9/3808 , C07F9/5355 , C07F9/572 , C07F9/58 , C07F9/65583 , C07F9/65586
摘要： Novel aromatic compounds which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 可用作鞘氨醇-1-磷酸调节剂的新型芳族化合物，可用于治疗与调节鞘氨醇-1-磷酸受体相关的各种疾病。
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6.发明申请AROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHONATE (S1P) RECEPTOR ACTIVITY 审中-公开具有丝氨酸1-磷酸（S1P）受体活性的芳香化合物公开(公告)号：US20110281822A1
公开(公告)日：2011-11-17
申请号：US13105590
申请日：2011-05-11
申请人： Janet A. Takeuchi , Ken Chow , Ling Li , Xiaoxia Liu
发明人： Janet A. Takeuchi , Ken Chow , Ling Li , Xiaoxia Liu
IPC分类号： A61K31/675 , A61K31/661 , A61P27/02 , A61P27/06 , A61P9/10 , A61P29/00 , A61P31/00 , A61P35/04 , A61P9/00 , A61P37/04 , A61P1/00 , A61P5/14 , A61P25/00 , A61P17/06 , A61P1/04 , A61P17/00 , A61P37/08 , A61P11/06 , A61P11/00 , A61P17/02 , A61Q19/08 , A61P19/00 , A61P19/10 , A61P21/00 , A61P19/02 , A61P21/04 , A61P25/28 , C07F9/141
CPC分类号： C07F9/3808 , C07F9/5355 , C07F9/572 , C07F9/58 , C07F9/65583 , C07F9/65586
摘要： Novel aromatic compounds which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 可用作鞘氨醇-1-磷酸调节剂的新型芳族化合物，可用于治疗与调节鞘氨醇-1-磷酸受体相关的各种疾病。
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7.发明授权Substituted bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators 失效取代的双环甲基胺衍生物作为鞘氨醇-1-磷酸受体调节剂公开(公告)号：US08513418B2
公开(公告)日：2013-08-20
申请号：US13445991
申请日：2012-04-13
申请人： Janet A. Takeuchi , Ling Li , Wha Bin Im
发明人： Janet A. Takeuchi , Ling Li , Wha Bin Im
IPC分类号： C07D215/12 , C07F9/09 , C07F9/38 , C07F9/60
CPC分类号： C07C215/08 , C07C217/54 , C07D215/12 , C07F9/091 , C07F9/3808 , C07F9/3834 , C07F9/60
摘要： The present invention relates to novel substituted bicyclic methyl amine derivatives which are useful as sphingosine-1-phosphate receptors modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及可用作鞘氨醇-1-磷酸受体调节剂并可用于治疗与调节鞘氨醇-1-磷酸受体相关的多种疾病的新型取代的二环甲基胺衍生物。
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8.发明授权公开(公告)号：US08362022B2
公开(公告)日：2013-01-29
申请号：US12811773
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
IPC分类号： A61K31/497 , A61K31/4439
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein, having the structure: are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了明确定义的杂环化合物，其可用作亚型选择性α2肾上腺素能激动剂。 因此，本文所述的具有以下结构的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种疾病。
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9.发明申请N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS 失效作为ALPHA2B或ALPHA2B和ALPHA2C ADRENOCEPTORS的亚型选择性调节剂的N-（1-苯基-2-芳基）-4,5-二氢-2H-吡喃-5-胺化合物公开(公告)号：US20100145061A1
公开(公告)日：2010-06-10
申请号：US12632494
申请日：2009-12-07
申请人： Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst
发明人： Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst
IPC分类号： C07D401/12 , C07D207/50
CPC分类号： C07D207/22 , C07D401/12
摘要： The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formula
摘要翻译： 本发明提供了N-（1-苯基-2-芳基乙基）-4,5-二氢-2H-吡咯-5-胺化合物的化合物，并且是α2B或α2B和α2C肾上腺素受体的亚型选择性调节剂，并且是 选自由式表示的化合物组
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10.发明申请SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 审中-公开选择性亚型ALPHA 2 ADRENERGIC AGENTS及其使用方法公开(公告)号：US20090239918A1
公开(公告)日：2009-09-24
申请号：US12408823
申请日：2009-03-23
申请人： Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Ken Chow , Karen M. Kedzie , Daniel W. Gil , Wenkui K. Fang
发明人： Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Ken Chow , Karen M. Kedzie , Daniel W. Gil , Wenkui K. Fang
IPC分类号： A61K31/426 , A61K31/4164 , A61K31/421
CPC分类号： A61K31/4164 , A61K31/421 , A61K31/426
摘要： The invention provides methods for treating pain in mammals. In particular, the invention provides well-defined aminoimidazolines, aminothiazolines, and aminooxazolines and pharmaceutical compositions thereof to treat pain.
摘要翻译： 本发明提供了治疗哺乳动物疼痛的方法。 特别地，本发明提供了明确定义的氨基咪唑啉，氨基噻唑啉和氨基恶唑啉及其药物组合物来治疗疼痛。
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