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1.发明授权Implantable pressure-actuated drug delivery systems and methods of manufacture and use 有权可植入的压力驱动药物输送系统及其制造和使用方法公开(公告)号：US08696740B2
公开(公告)日：2014-04-15
申请号：US12985015
申请日：2011-01-05
申请人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, Jr. , Jason J. Benkoski , Morgana M. Trexler
发明人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, Jr. , Jason J. Benkoski , Morgana M. Trexler
IPC分类号： A61F2/82
CPC分类号： A61M31/002 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61F2250/0071 , A61K9/0012 , A61K9/0024 , A61K9/0097 , A61L31/145 , A61L31/16 , A61L33/0017 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2420/02 , B05D1/005 , C23C14/22 , Y10T29/49826
摘要： Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
摘要翻译： 可植入的压力致动系统，以响应于系统空腔和外部环境之间的压力差而递送药物和/或其它物质，以及制造和使用方法。 可以调节压力破裂膜隔膜，以在期望的破裂阈值，破裂位置，所需的破裂模式和/或期望的破裂时间内破裂。 调谐可以包括材料选择，厚度控制，表面图案化，衬底支撑图案化。 空腔可以在破裂阈值以下加压或抽真空，并且可以提供隔膜保护层以防止在周围环境中过早破裂并在植入环境内消散。 药物递送系统可以在支架内实施以在血压降低时释放物质。 空腔可以包括用于治疗血块的血栓溶解药物或其他物质。
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2.发明申请Implantable Pressure-Actuated Drug Delivery Systems and Methods of Manufacture and Use 有权植入式压力驱动药物输送系统及其制造和使用方法公开(公告)号：US20120010698A1
公开(公告)日：2012-01-12
申请号：US12985015
申请日：2011-01-05
申请人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, JR. , Jason J. Benkoski , Morgana M. Trexler
发明人： Chao-Wei Hwang , Hala J. Tomey , Jon R. Rosar , Robert C. Matteson, III , George L. Coles, JR. , Jason J. Benkoski , Morgana M. Trexler
CPC分类号： A61M31/002 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61F2250/0071 , A61K9/0012 , A61K9/0024 , A61K9/0097 , A61L31/145 , A61L31/16 , A61L33/0017 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2420/02 , B05D1/005 , C23C14/22 , Y10T29/49826
摘要： Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
摘要翻译： 可植入的压力致动系统，以响应于系统空腔和外部环境之间的压力差而递送药物和/或其它物质，以及制造和使用方法。 可以调节压力破裂膜隔膜，以在期望的破裂阈值，破裂位置，所需的破裂模式和/或期望的破裂时间内破裂。 调谐可以包括材料选择，厚度控制，表面图案化，衬底支撑图案化。 空腔可以在破裂阈值以下加压或抽真空，并且可以提供隔膜保护层以防止在周围环境中过早破裂并在植入环境内消散。 药物递送系统可以在支架内实施以在血压降低时释放物质。 空腔可以包括用于治疗血块的血栓溶解药物或其他物质。
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公开(公告)号：US20130032059A1
公开(公告)日：2013-02-07
申请号：US13197116
申请日：2011-08-03
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
IPC分类号： G02C7/04 , C08L33/14 , C08L33/20 , C08L39/06 , B29B15/00 , C08L83/04 , C08L97/02 , B29C35/16 , B29D11/00 , C08L33/26 , C08L29/04
CPC分类号： B29D11/00038 , C08B1/003 , C08J3/075 , C08J2301/02 , C08L1/02 , C08L33/066 , C08L33/20 , C08L33/26 , C08L2205/02 , C08L2205/16 , G02B1/04 , G02B1/043 , G02C7/049 , C08L101/14 , C08L33/10 , C08L71/02 , C08L29/04 , C08L39/06 , C08L83/04
摘要： The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.
摘要翻译： 本发明提供具有以下性质的一种或多种纤维素水凝胶：高含水量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供一种制备纤维素水凝胶的方法，包括：（i）使纤维素与溶剂接触以活化纤维素; （ii）任选地从活化的纤维素中除去溶剂; （iii）基本上溶解活化的纤维素以形成溶液; （iv）使溶液凝胶化; 并且任选地（v）干燥凝胶并使凝胶再水合。 纤维素水凝胶可以具有许多用途，包括用作隐形眼镜。
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公开(公告)号：US08895158B2
公开(公告)日：2014-11-25
申请号：US13566074
申请日：2012-08-03
CPC分类号： B42D25/30 , B41M3/144 , B42D25/29 , B42D2035/34 , C06B23/008 , C23F1/00 , C23F4/04 , Y10T428/31587 , Y10T428/31601 , Y10T428/31609 , Y10T428/31692
摘要： An article includes a substrate with a plurality of independent taggant layers that each include metal oxide nanocrystals doped with at least one Lanthanide element. Each taggant layer includes metal oxide nanocrystals doped with a different Lanthanide element than each other taggant layer.
摘要翻译： 一种制品包括具有多个独立标签剂层的衬底，每个层包含掺杂有至少一种镧系元素的金属氧化物纳米晶体。 每个标记物层包括掺杂有不同的镧系元素的金属氧化物纳米晶体，而不是每个其他标记剂层。
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公开(公告)号：US20130040150A1
公开(公告)日：2013-02-14
申请号：US13566074
申请日：2012-08-03
CPC分类号： B42D25/30 , B41M3/144 , B42D25/29 , B42D2035/34 , C06B23/008 , C23F1/00 , C23F4/04 , Y10T428/31587 , Y10T428/31601 , Y10T428/31609 , Y10T428/31692
摘要： An article includes a substrate with a plurality of independent taggant layers that each include metal oxide nanocrystals doped with at least one Lanthanide element. Each taggant layer includes metal oxide nanocrystals doped with a different Lanthanide element than each other taggant layer.
摘要翻译： 一种制品包括具有多个独立标签剂层的衬底，每个层包含掺杂有至少一种镧系元素的金属氧化物纳米晶体。 每个标记物层包括掺杂有不同的镧系元素的金属氧化物纳米晶体，而不是每个其他标记剂层。
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6.发明申请Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof 有权包含生物相容性纤维素水凝胶膜的伤口愈合组合物及其使用方法公开(公告)号：US20120231038A1
公开(公告)日：2012-09-13
申请号：US13295515
申请日：2011-11-14
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
IPC分类号： A61K9/70 , A61K38/02 , A61K31/70 , A61K31/20 , A61K48/00 , A61K49/00 , A61K38/43 , A61K38/22 , A61K35/76 , A61K38/18 , A61K38/14 , A61K39/395 , A61K39/00 , A61K47/30 , A61K35/12 , A61P17/02 , A61P27/02 , A61K47/38
CPC分类号： A61K47/38 , A61K9/0051 , A61K31/00 , A61K35/12 , A61K35/76 , A61K38/18 , A61K38/22 , A61K38/39 , A61K38/43 , A61K39/00 , A61K49/00 , A61L15/42 , A61L15/44 , A61L15/60 , A61L2300/62 , A61L2300/64 , A61L2430/16 , C07K16/00 , C12N7/00 , C08L1/00
摘要： The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.
摘要翻译： 本发明提供了包含生物相容性水凝胶膜的伤口愈合组合物，其中所述水凝胶膜具有以下性质中的一种或多种：高水含量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供了治疗有需要的受试者的伤口的方法，包括使伤口与本发明的生物相容性纤维素水凝胶膜接触。
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7.发明授权Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof 有权包含生物相容性纤维素水凝胶膜的伤口愈合组合物及其使用方法公开(公告)号：US09211256B2
公开(公告)日：2015-12-15
申请号：US13295515
申请日：2011-11-14
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon , Daniel Mulreany , Qiongyu Guo
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon , Daniel Mulreany , Qiongyu Guo
IPC分类号： A61K31/74 , A61K9/00 , A61L15/42 , A61L15/44 , A61L15/60 , A61K31/00 , A61K38/39 , A61K35/12
CPC分类号： A61K47/38 , A61K9/0051 , A61K31/00 , A61K35/12 , A61K35/76 , A61K38/18 , A61K38/22 , A61K38/39 , A61K38/43 , A61K39/00 , A61K49/00 , A61L15/42 , A61L15/44 , A61L15/60 , A61L2300/62 , A61L2300/64 , A61L2430/16 , C07K16/00 , C12N7/00 , C08L1/00
摘要： The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.
摘要翻译： 本发明提供了包含生物相容性水凝胶膜的伤口愈合组合物，其中所述水凝胶膜具有以下性质中的一种或多种：高水含量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供了治疗有需要的受试者的伤口的方法，包括使伤口与本发明的生物相容性纤维素水凝胶膜接触。
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公开(公告)号：US08871016B2
公开(公告)日：2014-10-28
申请号：US13197116
申请日：2011-08-03
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
IPC分类号： G02C7/04 , C08L33/14 , C08L33/20 , G02B1/04 , B29D11/00 , C08J3/075 , C08B1/00 , C08L1/02 , C08L33/26 , C08L33/06
CPC分类号： B29D11/00038 , C08B1/003 , C08J3/075 , C08J2301/02 , C08L1/02 , C08L33/066 , C08L33/20 , C08L33/26 , C08L2205/02 , C08L2205/16 , G02B1/04 , G02B1/043 , G02C7/049 , C08L101/14 , C08L33/10 , C08L71/02 , C08L29/04 , C08L39/06 , C08L83/04
摘要： The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.
摘要翻译： 本发明提供具有以下性质的一种或多种纤维素水凝胶：高含水量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供一种制备纤维素水凝胶的方法，包括：（i）使纤维素与溶剂接触以活化纤维素; （ii）任选地从活化的纤维素中除去溶剂; （iii）基本上溶解活化的纤维素以形成溶液; （iv）使溶液凝胶化; 并且任选地（v）干燥凝胶并使凝胶再水合。 纤维素水凝胶可以具有许多用途，包括用作隐形眼镜。
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