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    Compressed
    1.
    发明申请
    Compressed 审中-公开
    压缩

    公开(公告)号：US20090226514A1

    公开(公告)日：2009-09-10

    申请号：US12400985

    申请日：2009-03-10

    申请人： Jayant Eknath Khanolkar ,  Martin Hallissey ,  Lynn Eileen Campbell Kilpatrick

    发明人： Jayant Eknath Khanolkar ,  Martin Hallissey ,  Lynn Eileen Campbell Kilpatrick

    IPC分类号： A61K9/20 ,  A61K31/05 ,  A61K31/35

    CPC分类号： A61K9/0007 ,  A23G3/004 ,  A23G3/364 ,  A23G3/42 ,  A23G3/54 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2077 ,  A61K9/209 ,  A61K31/045 ,  A23V2200/30

    摘要： The invention provides a compressed tablet including a volatile active agent, preferably menthol, within a spray-dried granule further comprising a starch carrier and, optionally, a polyol granulating agent. The compressed tablet can be a two layer tablet comprising an effervescent layer and a non-effervescent layer with the spray-dried granule incorporated into the effervescent layer. The tablets herein are useful for providing decongestant benefits.The present invention further relates to the use of starch for increasing the rate of release of menthol from a compressed tablet. The use of starch as a carrier for the volatile active agent has been found to not only improve its rate of release from the tablet compared to other carriers, such as gum arabic, or compared to not using a carrier at all, but also to impart improved smoothness to the tablet when sucked.

    摘要翻译： 本发明提供一种包含挥发性活性剂，优选薄荷醇的压缩片剂，该喷雾干燥颗粒还包含淀粉载体和任选的多元醇造粒剂。 压缩片剂可以是包含泡腾层和非泡腾层的双层片剂，其中喷雾干燥颗粒并入泡腾层。 本文中的片剂可用于提供减充血剂益处。 本发明还涉及淀粉用于增加压缩片剂中薄荷醇释放速率的用途。 已经发现使用淀粉作为挥发性活性剂的载体不仅提高了与其他载体如阿拉伯胶相比从片剂释放的速度，或者与根本不使用载体相比，而且与赋予 改善了吸入时片剂的平滑度。