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公开(公告)号：US20070249727A1
公开(公告)日：2007-10-25
申请号：US11657860
申请日：2007-01-25
申请人： Kelly Lee Martin , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines , Thomas Edward Huetter , Radhika R. Iyer , Daren K. Anness
发明人： Kelly Lee Martin , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines , Thomas Edward Huetter , Radhika R. Iyer , Daren K. Anness
IPC分类号： A61K31/135
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0095 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： The invention relates to a clear device: comprising a composition contained in a device; wherein said composition comprising a pharmaceutical active selected from the group consisting of phenylephrine, its free and addition salt forms, and mixtures thereof. Also disclosed are kits comprising: a composition contained in a device; wherein said composition comprising a pharmaceutical active selected from the group consisting of phenylephrine, its free and addition salt forms, and mixtures thereof.
摘要翻译： 本发明涉及一种清洁装置：包括装在装置中的组合物; 其中所述组合物包含选自去氧肾上腺素，其游离和加成盐形式及其混合物的药物活性物质。 还公开了试剂盒，其包含：包含在装置中的组合物; 其中所述组合物包含选自去氧肾上腺素，其游离和加成盐形式及其混合物的药物活性物质。
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公开(公告)号：US10022339B2
公开(公告)日：2018-07-17
申请号：US11408299
申请日：2006-04-21
申请人： Kelly Lee Martin , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines
发明人： Kelly Lee Martin , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines
IPC分类号： A61K31/137 , A61K31/473 , A61K31/485 , A61K31/495 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K31/519
摘要： Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the composition has a pH of from about 2 to about 5 and is substantially free of aldehydes.
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公开(公告)号：US20090226514A1
公开(公告)日：2009-09-10
申请号：US12400985
申请日：2009-03-10
CPC分类号： A61K9/0007 , A23G3/004 , A23G3/364 , A23G3/42 , A23G3/54 , A23P10/28 , A23V2002/00 , A61K9/0056 , A61K9/1652 , A61K9/2018 , A61K9/2077 , A61K9/209 , A61K31/045 , A23V2200/30
摘要： The invention provides a compressed tablet including a volatile active agent, preferably menthol, within a spray-dried granule further comprising a starch carrier and, optionally, a polyol granulating agent. The compressed tablet can be a two layer tablet comprising an effervescent layer and a non-effervescent layer with the spray-dried granule incorporated into the effervescent layer. The tablets herein are useful for providing decongestant benefits.The present invention further relates to the use of starch for increasing the rate of release of menthol from a compressed tablet. The use of starch as a carrier for the volatile active agent has been found to not only improve its rate of release from the tablet compared to other carriers, such as gum arabic, or compared to not using a carrier at all, but also to impart improved smoothness to the tablet when sucked.
摘要翻译： 本发明提供一种包含挥发性活性剂，优选薄荷醇的压缩片剂，该喷雾干燥颗粒还包含淀粉载体和任选的多元醇造粒剂。 压缩片剂可以是包含泡腾层和非泡腾层的双层片剂，其中喷雾干燥颗粒并入泡腾层。 本文中的片剂可用于提供减充血剂益处。 本发明还涉及淀粉用于增加压缩片剂中薄荷醇释放速率的用途。 已经发现使用淀粉作为挥发性活性剂的载体不仅提高了与其他载体如阿拉伯胶相比从片剂释放的速度，或者与根本不使用载体相比，而且与赋予 改善了吸入时片剂的平滑度。
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公开(公告)号：US09801400B2
公开(公告)日：2017-10-31
申请号：US12135243
申请日：2008-06-09
申请人： Nicholas James Cummins , Jayant Eknath Khanolkar , Vasiliki Poulopoulou , Vaishali Shailendra Rane
发明人： Nicholas James Cummins , Jayant Eknath Khanolkar , Vasiliki Poulopoulou , Vaishali Shailendra Rane
IPC分类号： A23G3/00 , A23L1/08 , A61K9/00 , A61K31/137 , A61K31/167 , A61K31/4748 , A61K47/12 , A61K47/38 , A61K47/46 , A23L29/00 , A23L29/262 , A23L21/25
CPC分类号： A23L21/25 , A23L29/06 , A23L29/262 , A23V2002/00 , A61K9/0095 , A61K31/137 , A61K31/167 , A61K31/4748 , A61K47/12 , A61K47/38 , A61K47/46 , C12Y302/01004 , A23V2200/214
摘要： Compositions comprising cellulosic polymers and natural honey that display reduced instability due to the presence of a chelant that inhibits the activity of naturally occurring cellulases are described. Methods of treating natural honey to inhibit cellulase activity comprising mixing the natural honey with a chelant and optionally heating the mixture are provided. Flavor compositions consisting of natural honey and a chelant, optionally in a carrier are further described.
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公开(公告)号：US20090017165A1
公开(公告)日：2009-01-15
申请号：US12135243
申请日：2008-06-09
申请人： Nicholas James Cummins , Jayant Eknath Khanolkar , Vasiliki Poulopoulou , Vaishali Shailendra Rane
发明人： Nicholas James Cummins , Jayant Eknath Khanolkar , Vasiliki Poulopoulou , Vaishali Shailendra Rane
CPC分类号： A23L21/25 , A23L29/06 , A23L29/262 , A23V2002/00 , A61K9/0095 , A61K31/137 , A61K31/167 , A61K31/4748 , A61K47/12 , A61K47/38 , A61K47/46 , C12Y302/01004 , A23V2200/214
摘要： Compositions comprising cellulosic polymers and natural honey that display reduced instability due to the presence of a chelant that inhibits the activity of naturally occurring cellulases are described. Methods of treating natural honey to inhibit cellulase activity comprising mixing the natural honey with a chelant and optionally heating the mixture are provided. Flavour compositions consisting of natural honey and a chelant, optionally in a carrier are further described.
摘要翻译： 描述了包含纤维素聚合物和天然蜂蜜的组合物，其显示由于存在抑制天然存在的纤维素酶的活性的螯合剂而导致的不稳定性。 提供天然蜂蜜处理以抑制纤维素酶活性的方法，包括将天然蜂蜜与螯合剂混合并任选加热混合物。 进一步描述由天然蜂蜜和螯合剂组成的风味组合物，任选地在载体中。
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公开(公告)号：US07138133B2
公开(公告)日：2006-11-21
申请号：US09974347
申请日：2001-10-10
申请人： Douglas Joseph Dobrozsi , Jerry William Hayes, II , Francis Joseph David Bealin-Kelly , Jayant Eknath Khanolkar , Benoit Maurice Mullet , Shane Michael DE LA Harpe , Brian James Robbins
发明人： Douglas Joseph Dobrozsi , Jerry William Hayes, II , Francis Joseph David Bealin-Kelly , Jayant Eknath Khanolkar , Benoit Maurice Mullet , Shane Michael DE LA Harpe , Brian James Robbins
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/4858 , A61K9/4866 , Y10S514/85 , Y10S514/975
摘要： The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.
摘要翻译： 本发明是口服给药的液体药物组合物，其表现出优异的物理稳定性，同时提供浓度水平的药物活性物质。 具体地说，这些组合物长时间不允许活性物沉淀或沉淀出溶液。 本发明的优点之一是组合物在使用前不需要搅动/摇动作为重新悬浮或溶解活性药物材料以确保均匀和一致的给药的方法。
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